Preparation method of starch-based large intestine targeted double-layer probiotics tablet
A technology based on probiotic tablets and starch, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of bioavailability to be improved, limited, and insignificant effects , to achieve good colon targeting, resistance to enzymatic hydrolysis, and effective maintenance of probiotic activity
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Embodiment 1
[0030] (1) Acid hydrolysis: Weigh 100g of waxy cornstarch, add water to adjust the slurry to 50% starch solution, adjust the pH of the starch solution to 2.0 with 0.5M HCI, and stir on a magnetic stirrer at 200rpm for 30min;
[0031] (2) Pre-drying: suction filter the starch slurry in step (1), break the filter residue into small pieces, dry at 45°C for 24 hours, and grind through a 100-mesh sieve;
[0032] (3) Baking at high temperature: Divide the dried starch granules in step (2) into two equal parts, one part is baked at 120°C for 4 hours, and the obtained sample is recorded as outer layer material K1; the other part is baked at 180°C for 5 hours Recorded as core material K2;
[0033] (4) Water washing: wash the above-mentioned baked samples K1 and K2 with water until the pH is neutral;
[0034] (5) Drying and sieving: K1 and K2 after washing were dried at 45°C for 20 hours, crushed and passed through a 100-mesh sieve;
[0035] (6) Probiotic dry powder: Centrifuge the La...
Embodiment 2
[0038] (1) Acid hydrolysis: Weigh 100g of waxy cornstarch, add water to adjust the slurry to a 50% starch solution, adjust the pH of the starch solution to 3.0 with 0.5M HCI, and stir on a magnetic stirrer at 300rpm for 30min;
[0039] (2) Pre-drying: suction filter the starch slurry in step (1), break the filter residue into small pieces, dry at 55°C for 18 hours, and grind through a 100-mesh sieve;
[0040] (3) Baking at high temperature: Divide the starch granules dried in step (2) into two parts, one part is baked at 130°C for 3 hours to obtain the outer layer material; the other part is baked at 190°C for 3 hours to obtain the core layer material ;
[0041] (4) Washing: wash the baked core layer material and outer layer material with water until the pH is neutral;
[0042] (5) Drying and sieving: the washed core material and outer layer material are dried at 45°C for 20 hours, crushed and passed through a 100-mesh sieve;
[0043] (6) Probiotic dry powder: Centrifuge the...
Embodiment 3
[0046] (1) Acid hydrolysis: Weigh 100g of waxy cornstarch, add water to adjust the slurry to a 50% starch solution, adjust the pH of the starch solution to 3.0 with 0.5M HCI, and stir on a magnetic stirrer at 300rpm for 30min;
[0047] (2) Pre-drying: suction filter the starch slurry in step (1), break the filter residue into small pieces, dry at 60°C for 14 hours, and grind through a 100-mesh sieve;
[0048] (3) Baking at high temperature: Divide the dried starch granules in step (2) into two parts, one part is baked at 140°C for 2 hours to obtain the outer layer material; the other part is baked at 195°C for 2 hours to obtain the core layer;
[0049] (4) Washing: washing the baked core layer and outer layer materials with water until the pH is neutral;
[0050] (5) Drying and sieving: the washed core layer and outer layer materials are dried at 45°C for 20 hours, crushed and passed through a 100-mesh sieve;
[0051] (6) Probiotic dry powder: Centrifuge the lactic acid bacte...
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