Application of 1,2,4-triazole heterocyclic compound in preparation of drugs to prevent or treat central system related diseases

A technology of heterocyclic compounds and triazoles, which is applied in the field of 1,2,4-triazole heterocyclic compounds, can solve the problems of not showing epileptic central nervous excitatory effects, and achieve good clinical application prospects and good sedation , Excellent inhibitory effect
CN110251518AInactive Publication Date: 2019-09-20QINGDAO UNIV OF SCI & TECH
6 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
QINGDAO UNIV OF SCI & TECH
Publication Date
2019-09-20
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to the technical field of 1,2,4-triazole heterocyclic compounds and discloses application of a 1,2,4-triazole heterocyclic compound in the preparation of drugs to prevent or treat central system related diseases. The 1,2,4-triazole heterocyclic compound [1,2,4]-triazolo-[1,5-a]pyrimidone heterocyclic compound shown as the general formula (I) or 7-alkoxy-1,2,4-triazolo-[1,5-a]pyrimidine heterocyclic compound shown as the general formula (II). The 1,2,4-triazole heterocyclic compound disclosed herein can well inhibit, on cellular models, intracellular calcium ion oscillations and 4-AP induced epilepsy, and on animal models (mouse), has good anti-epilepsy activity and significant calming effect.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to 1,2,4-triazole heterocyclic compounds, in particular to the application of 1,2,4-triazole heterocyclic compounds in the preparation of drugs for preventing or treating diseases related to the central system. Background technique

[0002] Excitement of the central nervous system often causes discomfort or diseases such as insomnia, anxiety, epilepsy, and mental disorders depending on the degree and type of excitement. The main means of treating central nervous system related diseases are psychological therapy, drug therapy or a combination of the two methods . Due to the shortcomings of existing therapeutic drugs such as low drug efficacy and large side effects, it is important to find and develop new molecular structures that inhibit central nervous system (transitional or abnormal) excitement with high efficiency and low toxicity. Theoretical and applied value.

[0003] Chinese patent CN106749271B discloses a class o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More