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Preparation of composite active polypeptide biological microlite freeze-dried powder

An active polypeptide, freeze-dried powder technology, applied in cosmetic preparations, cosmetic preparations, preparations for skin care, etc., can solve the problems of less novel and unique appearance, harsh storage conditions, unfavorable storage and transportation, etc. Appearance, anti-oxidant enhancement, UV protection effect

Inactive Publication Date: 2019-09-24
广州暨大美塑生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, the storage temperature of the active polypeptide freeze-dried powder is -20°C and below, and the storage conditions are very harsh, which is not conducive to storage and transportation. Therefore, it is urgent to improve the preservation activity and stability of the biologically active polypeptide freeze-dried powder, so that It can be stored for a long time in the refrigerator or at room temperature
[0004] At the same time, traditional freeze-dried powders are mostly loose lumps or powders, and rarely have novel and unique appearances.

Method used

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  • Preparation of composite active polypeptide biological microlite freeze-dried powder
  • Preparation of composite active polypeptide biological microlite freeze-dried powder
  • Preparation of composite active polypeptide biological microlite freeze-dried powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Containing bFGF active peptide mixture formula:

[0030]

[0031] Preparation:

[0032] Weigh the material according to the formula, dissolve it in deionized water, swell overnight at 4°C, filter and sterilize through a 0.22um microporous membrane, dispense it into vials, and put it into a freeze dryer. Turn on the freeze dryer and keep it at 4°C±1°C for 2 hours; cool down to below -20°C, keep the temperature of the freeze-drying chamber at -20±2°C, and pre-freeze the product for 6 hours; start vacuuming, when the vacuum reaches 10Pa After that, heat up; adjust the temperature of the freeze-drying chamber to rise slowly to 0.0°C, the temperature rise should not exceed 1.0°C per hour, and keep it under vacuum for 28 hours; continue to adjust the temperature of the freeze-drying chamber, and raise the temperature to 35°C at a rate of 5°C / h , keep warm for 3 hours. Introduce nitrogen, helium or argon, adjust the freeze-drying chamber to normal pressure, press the inne...

Embodiment 2

[0037] Containing EGF active peptide mixture formula:

[0038]

[0039] Preparation:

[0040] Weigh the material according to the formula, dissolve it in deionized water, swell overnight at 4°C, filter and sterilize through a 0.22um microporous membrane, dispense it into vials, and put it into a freeze dryer. Turn on the freeze dryer and keep it at 4°C±1°C for 3 hours; cool down to below -20°C, keep the temperature of the freeze-drying chamber at -20±2°C, and pre-freeze the product for 7 hours; start vacuuming, when the vacuum reaches 10Pa After that, heat up; adjust the temperature of the freeze-drying chamber to rise slowly to 0.0°C, the temperature rise should not exceed 1.0°C per hour, and keep it under vacuum for 25 hours; continue to adjust the temperature of the freeze-drying chamber, and raise the temperature to 30°C at a rate of 3°C / h , keep warm for 5 hours. Introduce nitrogen, helium or argon, adjust the freeze-drying chamber to normal pressure, press the inner...

Embodiment 3

[0045] Formula containing complex active peptide mixture:

[0046]

[0047] Preparation:

[0048] Weigh the material according to the formula, dissolve it in deionized water, swell overnight at 4°C, filter and sterilize through a 0.22um microporous membrane, dispense it into vials, and put it into a freeze dryer. Turn on the freeze dryer and keep it at 4°C±1°C for 3 hours; cool down to below -20°C, keep the temperature of the freeze-drying chamber at -20±2°C, and pre-freeze the product for 7 hours; start vacuuming, when the vacuum reaches 10Pa After that, heat up; adjust the temperature of the freeze-drying chamber to rise slowly to 0.0°C, and the temperature rise does not exceed 1.0°C per hour, and keep it under vacuum for 25 hours; continue to adjust the temperature of the freeze-drying chamber, and raise the temperature to 35°C at a rate of 10°C / h , keep warm for 3 hours. Feed nitrogen, helium or argon, adjust the freeze-drying chamber to normal pressure, press the inn...

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Abstract

The invention provides preparation of composite active polypeptide biological microlite freeze-dried powder, and is applied to the field of feature-beautifying anti-aging cosmetics. Composite active polypeptide is treated by a biological technique and freeze-dried powder is technically treated, so that effective feature-beautifying anti-aging active components are exerted. Composite active polypeptide containing mixed liquid is pretreated, and a freeze-drying technology is researched in details and improved, through the processes of solution prefreezing, primary drying and secondary drying, the prepared freeze-dried powder has scattering microlite surfaces. On one hand, the bioactivity and the stability of the composite bioactive polypeptide freeze-dried powder are improved, the obtained composite active polypeptide biological microlite freeze-dried powder can be stored for a long time under the condition of refrigeration or normal temperature, and on the other hand, the appearance of the freeze-dried powder can be improved. The surface of the active polypeptide biological microlite freeze-dried powder is different from the loose block or powder appearance surface of conventional freeze-dried powder. The technology is simple and easy to operate, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of beauty and anti-aging cosmetics, and specifically relates to a preparation of a composite active polypeptide biological microcrystal freeze-dried powder, a composition containing the composite active polypeptide biological microcrystal freeze-dried powder and its preparation, which can improve the biological activity and high complex activity. Stable, and has a scattering crystallite surface, can be stored for a long time in refrigeration or at room temperature. Background technique [0002] In recent years, with the rapid development of my country's economy and the improvement of living standards, people's demand for beauty and anti-aging has exploded. Bioactive peptides play important roles in the natural aging and care of the skin, such as cell proliferation, cell migration, angiogenesis, pigment formation, and protein synthesis and regulation. In addition to their own functions, various active peptides can als...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/02A61K8/60A61K8/34A61K8/44A61K8/65A61K8/73A61K8/49A61Q19/08A61Q19/00A61Q17/04
CPCA61K8/0245A61K8/345A61K8/44A61K8/4946A61K8/60A61K8/64A61K8/65A61K8/73A61K8/735A61K2800/84A61Q17/04A61Q19/004A61Q19/08
Inventor 夏黎明周爱梅徐晶欧春凤许晓华黄文羽
Owner 广州暨大美塑生物科技有限公司
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