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Low-frequency pulse electric field responsive target drug release system

An electric field response, low-frequency pulse technology, applied in the field of nano-biomedicine, can solve the problems of human injury, difficult clinical practice, and inability to obtain reasonable application, and achieves the effect of strong lethality and reduced injury.

Inactive Publication Date: 2019-09-24
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are two major defects in this system: (1) the voltage of the electric field provided by the electrode is too large to easily cause harm to the human body, and the operation is cumbersome, so it is difficult to apply to clinical practice.
(2) Due to the pH response characteristics of this system, it can only be applied to the transportation of oral drugs, mainly for the treatment of gastrointestinal diseases. At present, most tumor drugs enter the human body by injection, so this system cannot be used reasonably

Method used

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  • Low-frequency pulse electric field responsive target drug release system
  • Low-frequency pulse electric field responsive target drug release system
  • Low-frequency pulse electric field responsive target drug release system

Examples

Experimental program
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Embodiment 1

[0065] This embodiment provides a low-frequency pulsed electric field response targeted drug release system, the system is composed of mesoporous silica nanoparticles, electric field responsive functional molecules and targeting molecules, the mass of the targeting functional molecules accounted for the mass of the target 33.3% of the total mass of the drug delivery system, the mass of the electric field response functional component accounts for 4.3% of the total mass of the targeted drug delivery system, and the drug accounts for 23.7% of the total mass of the targeted drug delivery system. Pulsed electric fields control drug release.

[0066] The preparation method of the system provided in this embodiment is as follows:

[0067] 1. Synthesize mesoporous silica by soft template method, place the synthesized MSNs (0.8g) in 50mL toluene solution, and after ultrasonic separation for 30min, add 0.7ml 3-(methacryloyloxy)propyltrimethoxysilane ( referred to as MPS) at 40°C, mech...

Embodiment 2

[0072] Preparation of targeted drug release system loaded with doxorubicin (DOX) in response to low-frequency pulsed electric field (DOX@DMDR-FA)

[0073] The preparation method of the system provided in this embodiment is as follows:

[0074] 100mg of the composite nanoparticles in Example 1 were dispersed into a PBS solution (20ml, pH=6.5) containing 20mg of DOX, stirred for 48h under light-tight conditions, then centrifuged to remove the supernatant, and the doxorubicin was determined by ultraviolet-visible spectroscopy. The loading amount of doxorubicin was measured and calculated to be 23.7wt%. The electric field responsive targeted drug delivery system provided in this example is applied to the treatment of cancer through injection.

Embodiment 3

[0075] Example 3 This example provides a low-frequency pulsed electric field-responsive targeted drug delivery system, which is composed of mesoporous silica nanoparticles, electric field-responsive functional molecules and targeting molecules, and the mass of the targeting functional molecules accounts for 15% of the total mass of the targeted drug release system, the mass of the electric field response functional component accounts for 4.56% of the total mass of the targeted drug release system, and the drug accounts for 19wt% of the total mass of the targeted drug release system. The system controls drug release through low-frequency pulsed electric field.

[0076] The preparation method of the system provided in this embodiment is as follows:

[0077] 1. Synthesize mesoporous silica by soft template method, put the synthesized MSNs (0.8g) in 40mL toluene solution, after ultrasonic separation for 30min, add 0.7ml 3-(methacryloyloxy)propyltrimethoxysilane ( referred to as M...

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Abstract

The invention provides a low-frequency pulse electric field responsive target drug release system. The target drug release system contains functional polymer coated mesoporous silicon dioxide nanoparticles, target functional molecules linked to the surfaces of the functional polymer coated mesoporous silicon dioxide nanoparticles, and drugs loaded in pore canals of the functional polymer coated mesoporous silicon dioxide nanoparticles, wherein the mass of the functional polymer coated mesoporous silicon dioxide nanoparticles contained in the target drug release system is 67%-85% of the total mass of the target drug release system, the mass of the target functional molecules is 15%-33.3% of the total mass of the target drug release system, and the mass of the drugs is 5%-25% of the total mass of the target drug release system. The target drug release system is used for controlling drug release through a low-frequency pulse electric field.

Description

technical field [0001] The invention relates to a targeted drug release system responding to a low-frequency pulsed electric field, belonging to the field of nano-biomedicine. Background technique [0002] Cancer is the leading killer of the world's population. Currently, more than 50 different types of chemotherapy drugs are available for conventional tumor treatment. However, the therapeutic effect is unsatisfactory due to their low bioavailability and severe side effects. Therefore, the research and development of intelligent drug delivery system is of great significance to the treatment of tumors. With the development of science and technology, a variety of intelligent transport systems have been developed in recent years, and most of them use functional molecules that respond to various chemical or physical stimuli to control the release of drugs. Whether it is a chemical signal (acid-base, ion or oxidative molecule) or a physical signal (light, electricity, magnetic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/04A61K47/32A61K47/22A61K31/704A61P35/00
CPCA61K9/0009A61K9/0019A61K9/5115A61K9/5123A61K9/5138A61K31/704
Inventor 祝迎春焦亚静邵怡然王云丽王铭
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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