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Exhalation acquisition device for liver disease patients and photo-acoustic detection method for ammonia and methyl mercaptan in exhalations

A technology for collecting devices and patients, applied in measurement devices, sampling devices, color/spectral characteristic measurement, etc., can solve problems such as undetectable methyl mercaptan

Pending Publication Date: 2019-09-24
大连市第六人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, domestic and foreign methods for detecting blood ammonia in patients with liver diseases still have certain limitations and time limits, and the blood of patients needs to be collected, and methyl mercaptan cannot be detected in blood.

Method used

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  • Exhalation acquisition device for liver disease patients and photo-acoustic detection method for ammonia and methyl mercaptan in exhalations
  • Exhalation acquisition device for liver disease patients and photo-acoustic detection method for ammonia and methyl mercaptan in exhalations
  • Exhalation acquisition device for liver disease patients and photo-acoustic detection method for ammonia and methyl mercaptan in exhalations

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Experimental program
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Effect test

Embodiment 1

[0021] Embodiment 1: A kind of exhalation collection device for patients with liver diseases, including a respiratory mask 1 and an exhalation collection device, the respiratory mask 1 is an ear-hook type mask 1, the front of the mask 1 has an air outlet, and there are two holes on both sides of the air outlet. An air inlet valve 3, the mask 1 is a polyvinyl chloride mask 1, the air outlet is connected to the first gas pipeline, the first gas pipeline is equipped with a one-way valve 4, and the one-way valve 4 is located inside the mask 1 end, the first Molecular sieve 5 (preferably molecular sieve is three-layer molecular sieve) is installed inside the gas pipeline, the first gas pipeline is communicated with the second gas pipeline, and its connection is sealed by the spiral fixed turn 6, and the second gas pipeline and the The exhalation collection device is connected, and the joint is sealed by the helical fixed turn 6 .

[0022] The above-mentioned technical scheme connec...

Embodiment 2

[0029] Example 2: The working principle of the breath ammonia and methyl mercaptan detector: the wavelength-modulated laser passes through the photoacoustic cell, and the gas to be measured absorbs the light energy to generate a pulse pressure wave, that is, an acoustic signal, which is then detected by the silicon MEMS cantilever beam optical microscope. The sounder detects small changes in sound pressure, and finally detects the ppb level gas of exhaled ammonia and methyl mercaptan in patients with liver diseases.

[0030] This embodiment provides a kind of photoacoustic detection system of ammonia and methyl mercaptan, mainly by respiratory mask 1, ammonia and methyl mercaptan double light source 8 stable controllers, photoacoustic sensor, photoacoustic signal detection microphone, photoacoustic signal It consists of a processing system, a spectrum analyzer, a display, a micro-printer, a patient information input system, and a USB interface. The gas to be detected enters th...

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Abstract

The invention relates to an exhalation acquisition device for liver disease patients and a photo-acoustic detection method for ammonia and methyl mercaptan in exhalations, and belongs to the field of exhalation acquisition in order to solve the problems that a mask can be connected to or used by different exhalation acquisition devices, ensures sanitary requirements, and achieves the front-end filtering of exhalation acquisition. The exhalation acquisition device for liver disease patients includes a breathing mask and an exhalation acquisition device, wherein the breathing mask is an ear-hooked mask; the front surface of the mask has an air outlet; two air inlet valves are arranged on both sides of the air outlet; the mask is made of a polyvinyl chloride material; the air outlet is connected to a first air pipeline; the first air pipeline is provided with an one-way valve; the one-way valve is located inside a mask end; the first air pipeline is provided therein with a molecular sieve; the first air pipeline is in communication with the second air pipeline, and a joint is sealed by a spiral fixing hoop; and the second air pipeline is in communication with the exhalation acquisition device, and a joint is sealed by a spiral fixing hoop. The exhalation acquisition device for liver disease patients can be quickly replaced and ensures the sanitary requirements.

Description

technical field [0001] The invention belongs to the field of breath collection, and relates to a device and a method for detecting and diagnosing ammonia and methyl mercaptan in the breath of hepatic encephalopathy of patients with liver disease. Background technique [0002] Hepatic encephalopathy is the manifestation of the end stage of liver disease, and it is the main cause of death in patients with liver disease (about 35%). Hepatic encephalopathy is often caused by severe damage to the liver parenchyma or concurrent liver cirrhosis leading to extensive damage to the liver parenchyma. Upper gastrointestinal bleeding, infection, hypokalemia, surgical blows, improper ascites drainage, and the use of large amounts of diuretics and drugs that damage the liver are common causes of hepatic encephalopathy. The pathogenesis of hepatic encephalopathy is currently mainly based on ammonia poisoning as the main culprit. Under normal circumstances, the production and removal of am...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31G01N21/17G01N1/22
CPCG01N21/31G01N21/17G01N1/22G01N2021/1704
Inventor 高庆伟
Owner 大连市第六人民医院
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