A kind of sericin hydrogel with self-healing function and its preparation method and application
A self-healing, hydrogel technology, applied in prosthesis, medical science, etc., can solve problems such as poor bone repair effect, achieve excellent self-healing function and mechanical properties, high biological safety, and biocompatibility good sex effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0049] Dissolve 6g sericin powder in 30mL dimethyl sulfoxide, add 4g carbonyldiimidazole to fully react, pour the mixed solution into 100mL, 600mg / mL adipic acid dihydrazide solution, fully react for 24h, and dialyze the reaction solution with 3500D The bag was dialyzed for 48 hours and freeze-dried to obtain aminated sericin.
[0050] Dissolve 3g of sodium alginate powder in 300mL of deionized water, add 3.24g of sodium periodate, react in the dark for 5 hours at room temperature, add 4.5mL of ethylene glycol to terminate the reaction for 1 hour, dialyze the reaction solution with a 3500D dialysis bag for 72 hours, and freeze-dry to obtain oxidized sodium alginate.
[0051] Dissolve aminated sericin and oxidized sodium alginate in deionized water respectively to make a solution with a concentration of 150 mg / mL, add hydroxyapatite powder with 40% sericin mass in the aminated sericin solution, Ultrasound for 30 minutes, mix the aminated sericin solution mixed with hydroxyapat...
Embodiment 2～3
[0069] The preparation process is the same as that in Example 1, except that the added amount of hydroxyapatite powder is replaced by 20% and 60% of the mass of sericin respectively.
[0070] After testing, the sericin hydrogels prepared in Examples 2 and 3 respectively have excellent self-healing properties, and the healing efficiency reaches 85.3% and 73% respectively after 12 hours.
[0071] After the compression test (the test conditions are the same as in Example 1), the maximum stresses of the hydrogels prepared in Examples 2 and 3 were respectively 134kPa and 84kPa, and the maximum strains were 52% and 59% respectively.
Embodiment 4
[0073] Dissolve 6g sericin powder in 30mL dimethyl sulfoxide, add 4g carbonyldiimidazole to fully react, pour the mixed solution into 100mL, 600mg / mL adipic acid dihydrazide solution, fully react for 24h, and dialyze the reaction solution with 3500D The bag was dialyzed for 48 hours and freeze-dried to obtain aminated sericin.
[0074] Dissolve 3g of sodium alginate powder in 300mL of deionized water, add 3.24g of sodium periodate, react in the dark for 5 hours at room temperature, add 4.5mL of ethylene glycol to terminate the reaction for 1 hour, dialyze the reaction solution with a 3500D dialysis bag for 72 hours, and freeze-dry to obtain oxidized sodium alginate.
[0075] Aminated sericin and oxidized sodium alginate were dissolved in deionized water to prepare 150 mg / mL and 90 mg / mL solutions respectively, and hydroxyapatite powder with 40% sericin mass was added to the aminated sericin solution, Ultrasound for 30 minutes, mix the aminated sericin solution mixed with hydr...
PUM
| Property | Measurement | Unit |
|---|---|---|
| concentration | aaaaa | aaaaa |
| concentration | aaaaa | aaaaa |
| concentration | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More