Mineralized collagen/high molecule composite porous bone material and preparation method thereof

Abstract

The invention relates to a mineralized collagen / high molecule composite porous bone material and a preparation method thereof. The preparation method comprises the following steps that a collagen solution is prepared; a calcium-ion-containing aqueous solution is added; a phosphate-radical-ion-containing aqueous solution is added; the pH value is adjusted to be 8; a precipitate is washed, and suction filtration is conducted; freeze-drying is conducted; through grinding, dry mineralized collagen powder is prepared; a high molecule polymer solution is prepared; a polymer / calcium phosphate salt / collagen mixed solution is prepared; freeze-drying is conducted; ultrasonic suction and drying are conducted; sterilization is conducted, and accordingly the mineralized collagen-high molecule compositeporous bone material is prepared. The preparation method has the advantages of being low in cost, high in material utilization rate, easy to implement and the like, and the mineralized collagen-highmolecule composite porous bone material prepared through the method has the advantages of being high in homogeneity and mechanical strength, long in degradation time, low in organic solvent residue content, high in porosity, good in biocompatibility, capable of achieving cooperation of degradation time and bone remodeling and the like.

Description

[0001] This application is a divisional application of an invention patent application with the title of "mineralized collagen / polymer composite porous bone material and its preparation method", the application date of "October 31, 2016", and the application number of "201610928746.8". technical field [0002] The invention relates to the field of medical materials, in particular to a porous bone material prepared by using polymer, nano-phase calcium phosphate salt and collagen as raw materials and a preparation method thereof. Background technique [0003] According to statistics, there are more than 50 million patients with limb insecurity in my country, of which 5 million have amputated due to lack of bone reconstruction surgery and bone materials; There are 12 million patients with defects or bone injuries, and tens of millions of people with unsound bones; there are more than 400 million patients with tooth defects and missing teeth nationwide. These people urgently need...

AI Technical Summary

Problems solved by technology

However, since the degradation time of PLGA is faster with the copolymerization of PGA segment to PLA segment, it is not conducive to bone regeneration, so that the degradation time does not match the bone remodeling

In addition, in the prior art, when producing mineralized collagen dry powder, the local ion concentration is too large or too small, the washing time caused by phosphate ion and / or calcium ion residue is too long, the sediment is time-consuming to wash, and the utilization of calcium and phosphate In the preparation of mineralized collagen-polymer composite porous bone materials, the mechanical properties are low, the degradation time is short, the dispersibility of mineralized collagen dry powder is poor during preparation, the residual amount of organic solvent is too large and difficult to remove, and the porosity is low.

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