Skin-aging-resistant composition containing nicotinamide adenine dinucleotide and preparation method and application thereof

A nicotinamide adenine, anti-skin aging technology, applied in the field of medicine, can solve the problem that skin anti-aging is far from being satisfied, and achieve the effects of good effect, reducing wrinkles, and delaying skin aging.

Active Publication Date: 2019-10-08
SHENZHEN LANTERN SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, as a worldwide hot research field, the

Method used

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  • Skin-aging-resistant composition containing nicotinamide adenine dinucleotide and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0078] According to the preparation method of the NAD+ stock solution described in Research Example 1, a series of NAD+ solutions were prepared respectively, and the concentrations of NAD+ were 0%, 1%, 2%, 3%, 4%, 5%, 6%, 7% and 8%. %.

[0079] Volunteer subjects:

[0080] No less than 45 healthy volunteers were selected and randomly divided into 9 groups.

[0081] Selection criteria, exclusion criteria, termination and exclusion criteria: the same as "Research Example 1".

[0082] test steps :

[0083] Same as "Research Example 1".

[0084] Grading :

[0085] Same as "Research Example 1".

[0086] result :

[0087] All subjects in each group completed all the tests, and no termination or exclusion occurred. The average scores of each group are shown in Table 2.

[0088] Table 2 Effect of NAD+ dosage on skin anti-aging effect

[0089] NAD+ concentration (%) Anti-wrinkle effect whitening effect Hydrating effect average score 0 40 35 45 4...

Embodiment 1

[0138] Example 1 A composition I and a solution containing the composition

[0139] The composition of composition I (500g) described in the present embodiment is:

[0140] NAD+300g, palmitoyl tripeptide-1 75g, sodium ascorbyl phosphate 125g

[0141] Weigh NAD+ 300g, palmitoyl tripeptide-1 75g, sodium ascorbyl phosphate 125g and purified water 500g. The four are mixed and stirred evenly to obtain the target solution; the storage temperature is -15~-20°C to prevent the growth of microorganisms.

Embodiment 2

[0142] Example 2 anti aging lotion

[0143] The raw material composition of anti-aging lotion (1000g) described in this embodiment is: 100g of the solution containing composition I prepared in Example 1, 50g of glycerin, 30g of butanediol, 0.2g of disodium EDTA, 1g of allantoin, seaweed Sugar 5g, aloe vera extract 50g, p-hydroxyacetophenone 3g, 1,2-hexanediol 5g, PEG-40 hydrogenated castor oil 0.6g, essence 0.2g, purified water 755g.

[0144] Prepare according to the following method: Prepare each raw material according to the formula. Add purified water, glycerin, butylene glycol, disodium EDTA, allantoin, trehalose, and p-hydroxyacetophenone into a stirring pot, heat to 80-85° C., and keep warm for 30 minutes. Cool down to 45°C, add a mixed solution of PEG-40 hydrogenated castor oil and essence. Cool down to 35°C, add the solution containing composition I of Example 1, Aloe vera extract, and 1,2-hexanediol, and stir evenly. Filter with a 200-mesh filter, that is, too. ...

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Abstract

The invention discloses a skin-aging-resistant composition containing nicotinamide adenine dinucleotide. The composition comprises, by weight, 2-7 parts of nicotinamide adenine dinucleotide and further comprises, by weight, one or two of 0.25-2 parts of palmitoyl tripeptide-1 and 0.5-2 parts of sodium ascorbyl phosphate. The invention further provides a preparation method and application thereof.The composition has outstanding whitening, crease-resisting and moisturizing effects and can effectively delay skin aging.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition for delaying skin aging and having cosmetic effect, a preparation method and application thereof. Background technique [0002] The skin is the largest organ of the human body. It covers the body surface and directly contacts the external environment. It has the functions of protection, excretion, temperature regulation and external stimulation. The skin is divided into three layers: epidermis, dermis and subcutaneous tissue. The epidermis is on the surface of the skin and can be divided into two parts, the stratum corneum and the germinal layer. Keratinized cells make up the stratum corneum, which becomes dander after shedding. The cells of the germinal layer are constantly dividing to replenish the exfoliated cuticle. The germinal layer has melanocytes, which produce melanin to prevent ultraviolet rays from damaging internal tissues. The dermis is...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/64A61Q19/00A61Q19/08
CPCA61K8/64A61K8/676A61K8/675A61Q19/00A61Q19/08
Inventor 梅杰钱军张许昌方金波巫俊峰蒋仪
Owner SHENZHEN LANTERN SCI
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