Composition with lipase inhibitor and hydroxymethyl-glutaryl coenzyme A reductase inhibitor
A technology of hydroxymethylglutaryl coenzyme and lipase inhibitor, which is applied in the field of medicine
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Embodiment 1
[0025] Example 1 Preparation of a composition composed of a lipase inhibitor and a hydroxymethylglutaryl-CoA reductase inhibitor
[0026] The lipase inhibitor and the hydroxymethylglutaryl coenzyme A reductase inhibitor in the ratio of specific substances are fully mixed to obtain the product.
[0027] The ratio of the amount of substance in the test example of the present invention and the embodiment includes: 0.008:1, 0.01:1, 0.013:1, 0.016:1, 0.02:1, 0.025:1, 0.032:1, 0.04:1, 0.05: 1, 0.063:1, 0.079:1, 0.1:1, 0.126:1, 0.158:1, 0.2:1, 0.251:1, 0.316:1, 0.398:1, 0.501:1, 0.631:1, 0.794:1, 1:1, 1.259:1, 1.585:1, 1.995:1, 2.512:1, 3.162:1, 3.981:1, 5.012:1, 6.31:1, 7.943:1, 10:1, 12.589:1, 15.849: 1, 19.953:1, 25.119:1, 31.623:1, 39.811:1, 50.119:1, 63.096:1, 79.433:1, 100:1, 125.893:1, 158.489:1.
Embodiment 2
[0081] Example 2 Preparation of Oral Solid Formulation Containing a Composition of Lipase Inhibitor and Hydroxymethylglutaryl-CoA Reductase Inhibitor
[0082] Prescription (1000 unit dose)
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[0086] Preparation
[0087] Take 50g of the composition and the prescription amount of auxiliary materials, and pass through a 100-mesh sieve. Get the composition, lactose, microcrystalline cellulose, crospovidone and starch and mix thoroughly; get the hypromellose of the prescription amount, and prepare a solution with a concentration of 10% based on hypromellose, and add lactic acid Adjust the pH to 3.0-4.0, add it to the above-mentioned mixture to make a soft material, granulate with a 16-mesh sieve, and dry at 80°C for 3-4 hours. Use a 16-mesh sieve to sieve the granules, add the prescribed amount of micropowder silica gel and magnesium stearate, mix well, fill the capsules, and obtain capsules;
[0088] Take 50g of the composition and the pres...
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