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Composition with lipase inhibitor and hydroxymethyl-glutaryl coenzyme A reductase inhibitor
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A technology of hydroxymethylglutaryl coenzyme and lipase inhibitor, which is applied in the field of medicine
Inactive Publication Date: 2019-10-11
黄泳华
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[0009] In the prior art, there is no technical teaching that the combination of orlistat and hydroxymethylglutaryl-CoA reductase inhibitors simultaneously produces synergistic antibacterial effects and synergistic inhibition of histamine release
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Embodiment 1
[0025] Example 1 Preparation of a composition composed of a lipase inhibitor and a hydroxymethylglutaryl-CoA reductase inhibitor
[0026] The lipase inhibitor and the hydroxymethylglutaryl coenzyme A reductase inhibitor in the ratio of specific substances are fully mixed to obtain the product.
[0027] The ratio of the amount of substance in the test example of the present invention and the embodiment includes: 0.008:1, 0.01:1, 0.013:1, 0.016:1, 0.02:1, 0.025:1, 0.032:1, 0.04:1, 0.05: 1, 0.063:1, 0.079:1, 0.1:1, 0.126:1, 0.158:1, 0.2:1, 0.251:1, 0.316:1, 0.398:1, 0.501:1, 0.631:1, 0.794:1, 1:1, 1.259:1, 1.585:1, 1.995:1, 2.512:1, 3.162:1, 3.981:1, 5.012:1, 6.31:1, 7.943:1, 10:1, 12.589:1, 15.849: 1, 19.953:1, 25.119:1, 31.623:1, 39.811:1, 50.119:1, 63.096:1, 79.433:1, 100:1, 125.893:1, 158.489:1.
Embodiment 2
[0081] Example 2 Preparation of Oral Solid Formulation Containing a Composition of Lipase Inhibitor and Hydroxymethylglutaryl-CoA Reductase Inhibitor
[0087] Take 50g of the composition and the prescription amount of auxiliary materials, and pass through a 100-mesh sieve. Get the composition, lactose, microcrystallinecellulose, crospovidone and starch and mix thoroughly; get the hypromellose of the prescription amount, and prepare a solution with a concentration of 10% based on hypromellose, and add lactic acid Adjust the pH to 3.0-4.0, add it to the above-mentioned mixture to make a soft material, granulate with a 16-mesh sieve, and dry at 80°C for 3-4 hours. Use a 16-mesh sieve to sieve the granules, add the prescribed amount of micropowder silica gel and magnesiumstearate, mix well, fill the capsules, and obtain capsules;
[0088] Take 50g of the composition and the pres...
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technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition composed of a lipase inhibitor and a hydroxymethylglutaryl-CoA reductase inhibitor and a pharmaceutical preparation containing the composition. Background technique [0002] An allergic reaction is also known as anaphylaxis. It is tissue damage or physiological dysfunction caused by stimulation of the body by antigenic substances (such as bacteria, viruses, parasites, pollen, etc.). An abnormal or focal immune response. The so-called hypersensitivity reaction usually refers to type I hypersensitivity reaction, that is, immediate hypersensitivity reaction. The mechanism is that after the allergen enters the allergic person's body, specific antibodies are produced, and the latter binds to the surface of mast cells, making the body in an sensitized state. When exposed to the allergen for the first time, the mast cells degranulate and release various chem...
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