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Recombinant human truncated-type keratinocyte growth factor-1 eye drops and preparing method and application thereof

A keratinocyte and growth factor technology, applied in drug combination, pharmaceutical formulation, peptide/protein composition, etc., can solve the problem of not promoting blood vessel growth, improve stability and biological activity, promote corneal repair, and have good industrial application prospects Effect

Active Publication Date: 2019-10-18
CHONGQING PEG BIO BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patent shows that the eye drops can promote the repair of corneal damage without promoting blood vessel growth

Method used

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  • Recombinant human truncated-type keratinocyte growth factor-1 eye drops and preparing method and application thereof
  • Recombinant human truncated-type keratinocyte growth factor-1 eye drops and preparing method and application thereof
  • Recombinant human truncated-type keratinocyte growth factor-1 eye drops and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1: A preparation method of recombinant human truncated keratinocyte growth factor-1 eye drops:

[0055] S1 Disperse polyvinyl alcohol in 500mL of water for injection, autoclave at 121°C, and cool to room temperature to obtain thickener stock solution;

[0056] S2 Dissolve recombinant human truncated keratinocyte growth factor-1, citrate buffer system, histidine, mannitol, sodium chloride, Tween 20, and 2 mg sucrose in 400 mL of water for injection, and use a 0.22 μm filter membrane to dissolve Bacterial filtration to obtain recombinant human truncated keratinocyte growth factor-1 mixed solution;

[0057] S3 Under aseptic conditions, mix the thickener stock solution obtained in S1 and the recombinant human truncated keratinocyte growth factor-1 mixture in S2 evenly, adjust to 1 L with sterile water for injection, and then use 0.22 μm sterile grade filter to obtain recombinant human truncated keratinocyte growth factor-1 eye drops;

[0058] S4 Aseptically fillin...

Embodiment 2

[0060] Embodiment 2: The difference with Embodiment 1 is that each component and its consumption are as shown in Table 1.

Embodiment 3

[0061] Embodiment 3: The difference from Embodiment 1 is that each component and its consumption are as shown in Table 1.

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Abstract

The invention discloses recombinant human truncated-type keratinocyte growth factor-1 eye drops. The recombinant human truncated-type keratinocyte growth factor-1 eye drops are composed of recombinanthuman truncated-type keratinocyte growth factors-1 and auxiliary materials. The preparing method of the eye drops comprises the steps of preparing a thickener stock solution, preparing a recombinanthuman truncated-type keratinocyte growth factor-1 mixed solution, mixing the two solutions, and conducting aseptic filtration and volume metering. The eye drops can be used for promoting cornea repair, does not promote the growth of blood vessels, and have the advantage of being capable of improving the stability and biological activity of the recombinant human truncated-type keratinocyte growth factors-1 in the eye drops. Besides, the method is used for obtaining the aseptic recombinant human truncated-type keratinocyte growth factor-1 eye drops. The eye drops are applied to treating cornealinjuries, and have a good industrial application prospect.

Description

technical field [0001] The invention relates to the field of eye drops, more specifically, it relates to a recombinant human truncated keratinocyte growth factor-1 eye drop and its preparation method and application. Background technique [0002] The cornea is a connective tissue with no blood vessels growing in the 6 / 1 of the anterior arm. Because the cornea is exposed to various harsh environments, it is extremely vulnerable to chemical, physical and other external stimuli, resulting in slow self-repair of the cornea and a long course of disease. At the same time, the integrity and transparency of the cornea after eye surgery are also very important for the recovery of vision. [0003] Currently, there are calf serum eye ointment, Beifushu (recombinant bovine basic fibroblast growth factor eye drops), Yibei (recombinant human epidermal growth factor eye drops), etc. Epidermal growth factor binds to the EGF receptor adjacent to the basement membrane of the wound, so that t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K9/08A61K47/12A61K47/18A61K47/32A61K47/26A61K47/02A61K47/10A61P27/02
CPCA61K38/1825A61K9/08A61K9/0048A61K47/12A61K47/18A61K47/32A61K47/26A61K47/02A61K47/10A61P27/02
Inventor 何勇黄金凤覃晓兰何跃冷国政范开
Owner CHONGQING PEG BIO BIOTECH CO LTD
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