An acid-responsive fe 3 o 4 -rgo-mtx nano medicine and its preparation method and application
A nano-drug and nano-particle technology, applied in the fields of nano-drugs, drug combinations, nano-technology, etc., can solve the problems of difficult control of drug release, toxic and side effects, poor biocompatibility of nanoparticles and poor drug loading, etc. Accepts functional groups, avoids damage, is easily doped and chemically modified
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Embodiment 1
[0035] Weigh 1.08g FeCl in turn 3 ·6H 2 O, 3.0g sodium acetate and 1.0g PEI, measure 40mL of ethylene glycol, put it in a 50mL beaker, stir ultrasonically for 20min to make the system disperse uniformly, then add the weighed 1.0g RGO, continue ultrasonic stirring for 10min, to obtain a uniformly dispersed Mix liquids. The homogeneous mixed liquid was transferred into a 100 mL polytetrafluoroethylene reaction kettle, and the reaction was carried out at 200 °C for 10 h. After the reaction, the product was poured out, and the product was extracted by magnetic decantation, washed with deionized water three times, and washed with ethanol three times. Finally, the product was dried in a vacuum oven at 30°C to obtain dry Fe 3 O 4-RGO nanoparticles.
[0036] Weigh 60 mg of dry Fe in turn 3 O 4 -RGO nanoparticles, 12mg MTX and 20mL deionized water were placed in a beaker, and the system was uniformly dispersed by ultrasonic for 8min. Then transferred to a three-necked flask, an...
Embodiment 2
[0040] Weigh 1.08g FeCl in turn 3 ·6H 2 O, 3.0g sodium acetate and 1.0g PEI, measure 40mL of ethylene glycol, put it in a 50mL beaker, stir ultrasonically for 20min to make the system evenly dispersed, then add the weighed 2.0g RGO, continue ultrasonic stirring for 10min, to obtain a uniform dispersion of mixed liquids. The above homogeneous mixed liquid was transferred into a 100 mL polytetrafluoroethylene reaction kettle, and the reaction was carried out at 200 °C for 10 h. After the reaction, the product was poured out, and the product was extracted by magnetic decantation, washed with deionized water three times, and washed with ethanol three times. Finally, the product was dried in a vacuum oven at 30 °C to obtain dry Fe 3 O 4 -RGO nanoparticles.
[0041] Weigh 60 mg of dry Fe in turn 3 O 4 -RGO nanoparticles, 20mg MTX and 20mL deionized water were placed in a beaker, and the system was uniformly dispersed by ultrasonic for 8min. Then transferred to a three-necked...
Embodiment 3
[0044] Weigh 1.08g FeCl in turn 3 ·6H 2 O, 3.0g sodium acetate and 0.5g PEI, measure 40mL ethylene glycol, put it in a 50mL beaker, stir ultrasonically for 20min to make the system disperse uniformly, then add the weighed 1.0g RGO, continue ultrasonic stirring for 10min, to obtain a uniform dispersion of mixed liquids. The above homogeneous mixed liquid was transferred into a 100 mL polytetrafluoroethylene reaction kettle, and reacted at 190 °C for 8 h. After the reaction, the product was poured out, and the product was extracted by magnetic decantation, washed with deionized water three times, and washed with ethanol three times. Finally, the product was dried in a vacuum oven at 30 °C to obtain dry Fe 3 O 4 -RGO nanoparticles.
[0045] Weigh 60 mg of dry Fe in turn 3 O 4 -RGO, 12 mg MTX and 20 mL of deionized water were placed in a beaker, and the system was uniformly dispersed by ultrasonic for 8 min. Then transferred to a three-necked flask, and reacted at 25°C in ...
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