Double crosslinked hydrogel based on calcium peroxide/polymer oxygen generating particles and preparation method of hydrogel

A calcium peroxide and polymer technology, applied in the field of medical biomaterials, can solve problems such as inconvenient use, insufficient mechanical strength, and short oxygen production time, and achieve the effect of slowing down the reaction and increasing the oxygen content
CN110343352AActive Publication Date: 2019-10-18TIANJIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN UNIV
Publication Date
2019-10-18

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Abstract

The invention discloses a double crosslinked hydrogel based on calcium peroxide / polymer oxygen generating particles and a preparation method of the hydrogel. The hydrogel is characterized in that thecalcium peroxide / polymer composite particles are introduced into a sodium alginate dopamine solution, crosslinking points are formed by calcium ions and carboxyl groups of sodium alginate, crosslinking points are also formed by self-crosslinking of dopamine, a mass concentration of calcium chloride is 3 wt%, and a mass concentration of the polymer is 3-60 wt%; and the hydrogel is a double crosslinked injectable hydrogel. Sodium alginate is used as a skeleton of the polymer, is simply modified by dopamine, and then is mixed with the calcium peroxide / polymer oxygen generating particles to prepare the physicochemical double crosslinked injectable oxygen generating hydrogel in one step. A compressive strength of the double crosslinked hydrogel can be up to 247+ / -1.15 KPa; and the oxygen content inside the hydrogel is increased, and the inside of the hydrogel maintains a high oxygen environment for 4 days or more at 37 DEG C. In addition, the used materials of the prepared injectable oxygengenerating hydrogel are non-toxic or low-toxic.
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Description

technical field

[0001] The invention relates to a double-crosslinked hydrogel based on calcium peroxide / polymer oxygen-generating particles and a preparation method thereof, belonging to the technical field of medical biomaterials. Background technique

[0002] Tissue engineering shows broad application prospects in the treatment of diseases. In recent years, studies have found that when large-scale engineered tissues are constructed, due to the lack of sufficient oxygen supply in the central area, the constructed engineered tissues are incomplete and affect their ability to respond to damage. tissue repair. Therefore, it is expected to develop an oxygen-generating scaffold material that can provide certain mechanical strength, suitable oxygen concentration and oxygen-generating time during the construction of engineered tissues.

[0003] Hydrogel is a new type of biological scaffold widely used in tissue engineering. It can reach more than 90% water content and a larger me...

Claims

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