Double crosslinked hydrogel based on calcium peroxide/polymer oxygen generating particles and preparation method of hydrogel

A calcium peroxide and polymer technology, applied in the field of medical biomaterials, can solve problems such as inconvenient use, insufficient mechanical strength, and short oxygen production time, and achieve the effect of slowing down the reaction and increasing the oxygen content

Active Publication Date: 2019-10-18
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On this basis, in order to improve the shortcomings of the oxygen-generating gel, such as insufficient mechanical strength, short oxygen-generating time, and inconvenient use, we first proposed to combine calcium peroxide / polymer oxygen-generating particles with dopamine-modified sodium alginate , to prepare a new oxygen-producing double cross-linked hydrogel

Method used

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  • Double crosslinked hydrogel based on calcium peroxide/polymer oxygen generating particles and preparation method of hydrogel
  • Double crosslinked hydrogel based on calcium peroxide/polymer oxygen generating particles and preparation method of hydrogel
  • Double crosslinked hydrogel based on calcium peroxide/polymer oxygen generating particles and preparation method of hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of calcium peroxide / polyisopropylacrylamide oxygen-generating particles

[0030]Weigh 3g of anhydrous calcium chloride, dissolve 6g of polyisoacrylacrylamide in 130mL of deionized water, stir until it is completely dissolved, then add 15mL of 25% ammonia water to the mixed solution, stir for 1 hour, and then add 20mL of 30% hydrogen peroxide was added dropwise into the reaction solution, and the stirring speed was 100 r / min. After reacting at room temperature for 4 hours, then add 0.1mol / L sodium hydroxide solution until the pH value of the solution reaches 11, centrifuge at a speed of 1000r / min for 5 minutes to separate the precipitate, wash the resulting precipitate with alkali three times, and then use The precipitate was washed with deionized water until the pH of the filtrate was 8.0. Then vacuum-dry at 45° C. for 48 hours to obtain calcium peroxide / polyisopropylacrylamide oxygen-generating particles.

Embodiment 2

[0031] Example 2: Preparation of calcium peroxide / polycaprolactam oxygen-generating particles

[0032] Weigh 3g of anhydrous calcium chloride, dissolve 30g of polycaprolactam in 130mL of deionized water, stir until it is completely dissolved, then add 15mL of 25% concentrated ammonia water to the mixed solution, stir for 2 hours, and then add 20mL of 30% polycaprolactam Hydrogen peroxide was added dropwise into the reaction solution, and the stirring speed was 500r / min. After reacting at room temperature for 6 hours, then add 0.1mol / L sodium hydroxide solution until the pH value of the solution reaches 11.5, centrifuge at a speed of 5000r / min for 5 minutes to separate the precipitate, wash the resulting precipitate with alkali three times, and then use The precipitate was washed with deionized water until the pH of the filtrate was 8.5. Then vacuum-dry at 50° C. for 36 hours to obtain calcium peroxide / polycaprolactam oxygen-generating particles.

Embodiment 3

[0033] Example 3: Preparation of Calcium Peroxide / Polyethylene Glycol Oxygen Particles

[0034] Weigh 3g of anhydrous calcium chloride, dissolve 60g of polyethylene glycol in 130mL of deionized water, stir until it is completely dissolved, then add 15mL of 25% concentrated ammonia water into the mixed solution, stir for 4 hours, and then add 20mL of 20mL with a mass fraction of 30 % hydrogen peroxide was added dropwise into the reaction solution, and the stirring speed was 1000r / min. After reacting at room temperature for 8 hours, add 0.1mol / L sodium hydroxide solution until the pH value of the solution reaches 12, centrifuge at a speed of 10000r / min for 5 minutes to separate the precipitate, wash the obtained precipitate with alkali three times, and then use deionized The precipitate was washed with water until the pH of the filtrate was 9. Then vacuum-dry at 60° C. for 24 hours to obtain calcium peroxide / polyethylene glycol oxygen-generating particles.

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Abstract

The invention discloses a double crosslinked hydrogel based on calcium peroxide / polymer oxygen generating particles and a preparation method of the hydrogel. The hydrogel is characterized in that thecalcium peroxide / polymer composite particles are introduced into a sodium alginate dopamine solution, crosslinking points are formed by calcium ions and carboxyl groups of sodium alginate, crosslinking points are also formed by self-crosslinking of dopamine, a mass concentration of calcium chloride is 3 wt%, and a mass concentration of the polymer is 3-60 wt%; and the hydrogel is a double crosslinked injectable hydrogel. Sodium alginate is used as a skeleton of the polymer, is simply modified by dopamine, and then is mixed with the calcium peroxide / polymer oxygen generating particles to prepare the physicochemical double crosslinked injectable oxygen generating hydrogel in one step. A compressive strength of the double crosslinked hydrogel can be up to 247+ / -1.15 KPa; and the oxygen content inside the hydrogel is increased, and the inside of the hydrogel maintains a high oxygen environment for 4 days or more at 37 DEG C. In addition, the used materials of the prepared injectable oxygengenerating hydrogel are non-toxic or low-toxic.

Description

technical field [0001] The invention relates to a double-crosslinked hydrogel based on calcium peroxide / polymer oxygen-generating particles and a preparation method thereof, belonging to the technical field of medical biomaterials. Background technique [0002] Tissue engineering shows broad application prospects in the treatment of diseases. In recent years, studies have found that when large-scale engineered tissues are constructed, due to the lack of sufficient oxygen supply in the central area, the constructed engineered tissues are incomplete and affect their ability to respond to damage. tissue repair. Therefore, it is expected to develop an oxygen-generating scaffold material that can provide certain mechanical strength, suitable oxygen concentration and oxygen-generating time during the construction of engineered tissues. [0003] Hydrogel is a new type of biological scaffold widely used in tissue engineering. It can reach more than 90% water content and a larger me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/24C08L77/02C08L71/02C08L5/04C08K3/22C08J3/075C08J3/24
CPCC08J3/075C08J3/243C08J2333/24C08J2377/02C08J2371/02C08J2405/04C08K3/22
Inventor 李俊杰姚芳莲罗巧悦孙红
Owner TIANJIN UNIV
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