3,4-methylenedioxy methcathinone detection methods

A dioxymethcathinone and methylene technology, which is applied in the detection field of 3,4-methylenedioxymethcathinone, can solve the problems of lack of new psychoactive substances and the like

Inactive Publication Date: 2019-10-18
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the research on new psychoactive substances in our country is still very scarce, and the qualitative and quantitative detection method for the controlled 3,4-methylenedioxymethcathinone is still blank. Therefore, it is urgent to establish a qualitative and quantitative detection method for related Case investigation and prosecution provide technical support

Method used

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  • 3,4-methylenedioxy methcathinone detection methods
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  • 3,4-methylenedioxy methcathinone detection methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Embodiment 1, carry out qualitative analysis to Methylone in suspected drug sample with gas chromatography-mass spectrometry (GC-MS)

[0098] 1. Reagents and standard substances, instruments and measuring instruments

[0099] 1.1 Reagents and standard substances

[0100] All reagents used in this method are of analytical grade.

[0101] Extraction reagent: Methanol.

[0102] Traceable reference material: Methylone.

[0103] 1.2 Instruments and measuring instruments

[0104] Gas Chromatograph (GC) equipped with Flame Ionization Detector (FID).

[0105] Gas chromatography-mass spectrometry (GC-MS), a quadrupole mass spectrometer equipped with a standard electron impact (EI) source.

[0106] centrifuge.

[0107] Electronic balance, actual division value d=0.01mg.

[0108] oscillator.

[0109] 10mL and 1mL pipettes or pipettes.

[0110] 10mL bottle top pipette.

[0111] Note: All instruments and measuring instruments involved must pass the metrological verificatio...

Embodiment 2

[0136] Embodiment 2, gas chromatography-hydrogen flame ionization detector (GC-FID) carries out quantitative analysis to the Methylone in the suspected drug sample

[0137] 1. Reagents and standard substances, instruments and measuring instruments

[0138] 1.1 Reagents and standard substances

[0139] All reagents used in this method are of analytical grade.

[0140] Extraction reagent: Methanol.

[0141] Traceable reference material: Methylone.

[0142] 1.2 Instruments and measuring instruments

[0143] Gas Chromatograph (GC) equipped with Flame Ionization Detector (FID).

[0144] Gas chromatography-mass spectrometry (GC-MS), a quadrupole mass spectrometer equipped with a standard electron impact (EI) source.

[0145] centrifuge.

[0146] Electronic balance, actual division value d=0.01mg.

[0147] oscillator.

[0148] 10mL and 1mL pipettes or pipettes.

[0149] 10mL bottle top pipette.

[0150] Note: All instruments and measuring instruments involved must pass the ...

Embodiment 3

[0232] Example 3, Methylone in suspected drug samples was qualitatively analyzed by liquid chromatography-tandem mass spectrometry (LC-MS / MS) in multiple reaction monitoring (MRM) mode

[0233] 1. Reagents and standard substances, instruments and measuring instruments

[0234] 1.1 Reagents and standard substances

[0235] The reagents used are chromatographically pure, and the test water is first-grade water (see GB / T 6682-2008). The reagents and standard substances include:

[0236] a) Reagents: methanol, acetonitrile, formic acid;

[0237] b) Traceable reference material: Methylone;

[0238] c) 0.1% formic acid aqueous solution: measure 1mL of formic acid, add water to dissolve and dilute to 1000mL, mix well, filter through a 0.22μm filter membrane, and let it stand for use after ultrasonication;

[0239] d) Standard stock solution: Weigh the Methylone standard substance, dissolve it with methanol respectively, prepare the standard stock solution of 2.5 mg / mL, store it in...

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Abstract

The invention discloses 3,4-methylenedioxy methcathinone detection methods. One method in the invention performs organic solvent extraction on Methylone in a suspected drug sample, performs qualitative analysis by using gas chromatography-mass spectrography (GC-MS), and performs quantitative analysis on Methylone by using a gas chromatography-flame ionization detector (GC-FID). The other method inthe method performs organic solvent extraction on Methylone in the suspected drug sample, performs qualitative analysis in a multi-reaction monitoring (MRM) mode by using a liquid chromatography-tandem mass spectrometry (LC-MS/MS), and performs quantitative analysis on Methylone by using a liquid chromatography-diode array or ultraviolet detector (LC-DVD) or LC-UV).

Description

technical field [0001] The invention belongs to the field of drug judicial detection, and in particular relates to a detection method of 3,4-methylenedioxymethcathinone. Background technique [0002] New psychoactive substances, English name New psychoactive substances, referred to as NPS, early called Legal Highs or Designer Drug, Chinese called "legal stimulants" or "planning drugs", is the research and production of some controlled drugs in order to avoid crackdowns. The drug analogs obtained by structural modification have similar effects to controlled drugs, and some have stronger excitatory, hallucinogenic, and anesthetic effects. The United Nations Office on Drugs and Crime (UNODC) divides new psychoactive substances into 9 categories, namely: synthetic cannabinoids, cathinones, phenethylamines, tryptamines, piperazines, ketamines and benzene rings. Ridines, aminoindenes, plants and others. [0003] At present, the research on new psychoactive substances in our coun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34
CPCG01N30/02G01N30/06G01N30/34G01N2030/047G01N2030/062G01N2030/342
Inventor 钱振华赵彦彪郑晓雨
Owner INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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