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Hydrophobic paper SERS substrate, preparation method thereof and application thereof

A hydrophobic, paper-based technology, applied in the field of detection, can solve the problems of inconvenient substrate carrying, high cost of support, lack of flexibility, etc., and achieve the effects of long shelf life, low detection limit and low cost of sol.

Inactive Publication Date: 2019-10-25
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two kinds of supports are costly, are not environmentally friendly, have no flexibility, and are not easy to carry on the substrate

Method used

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  • Hydrophobic paper SERS substrate, preparation method thereof and application thereof
  • Hydrophobic paper SERS substrate, preparation method thereof and application thereof
  • Hydrophobic paper SERS substrate, preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation of a paper-based modified SERS substrate for detection of trace molecules and its detection of R6G

[0046] In situ reduction of silver nanoparticles on cellulose nanocrystals to form a cellulose nanocrystal-silver composite (CNC-Ag)

[0047]Add 10 mL of 8 mmol / L silver nitrate solution into 10 mL of 0.4% CNC suspension and stir for 30 min; boil the above suspension until its color turns orange; add 5 mL of 1% (wt) sodium citrate solution while stirring, Continue to boil for 10 minutes to obtain a cellulose nanocrystal-silver composite material (CNC-Ag).

[0048] Cellulose nanocrystal-silver (CNC-Ag) composite deposited on filter paper to form a paper-based SERS substrate

[0049] Take 10 mL of the prepared CNC-Ag, pass it through a water-based microporous filtration membrane with a pore size of 0.22um and a diameter of 50mm, and filter it with a 100mLG4 glass sand core funnel device, and dry it for later use.

[0050] Hydrophobic alkylthiol modifi...

Embodiment 2

[0053] Preparation of a paper-based modified SERS substrate for detection of trace molecules and its detection of R6G

[0054] In situ reduction of silver nanoparticles on cellulose nanocrystals to form a cellulose nanocrystal-silver composite (CNC-Ag)

[0055] Add 10 mL of 8 mmol / L silver nitrate solution into 10 mL of 0.4% CNC suspension and stir for 30 min; boil the above suspension until its color turns orange; add 10 mL of 1% (wt) sodium citrate solution under stirring , and continue to boil for 5-15 minutes to obtain a cellulose nanocrystal-silver composite material (CNC-Ag).

[0056] Cellulose nanocrystal-silver (CNC-Ag) composite deposited on filter paper to form a paper-based SERS substrate

[0057] Take 15 mL of the prepared CNC-Ag, pass it through a water-based microporous filtration membrane with a pore size of 0.22 um and a diameter of 50 mm, and filter it with a 100 mLG4 glass sand core funnel device, and dry it for later use.

[0058] Hydrophobic alkyl...

Embodiment 3

[0063] Preparation of a paper-based modified SERS substrate for detection of trace molecules and its detection of phenylethanolamine A

[0064] In situ reduction of silver nanoparticles on cellulose nanocrystals to form a cellulose nanocrystal-silver composite (CNC-Ag)

[0065] Add 10 mL of 8 mM silver nitrate solution into 10 mL of 0.4% CNC suspension and stir for 30 min; boil the above suspension until its color turns orange; add 10 mL of 1% (wt) sodium citrate solution under stirring, continue Boil for 5-15 minutes to prepare cellulose nanocrystal-silver composite material (CNC-Ag).

[0066] Cellulose nanocrystal-silver (CNC-Ag) composite deposited on filter paper to form a paper-based SERS substrate

[0067] Take 15 mL of the prepared CNC-Ag, pass it through a water-based microporous filtration membrane with a pore size of 0.22 um and a diameter of 50 mm, and filter it with a 100 mLG4 glass sand core funnel device, and dry it for later use.

[0068] Hydrophobic a...

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Abstract

The invention discloses a hydrophobic paper SERS substrate, a preparation method thereof and an application thereof. The natural wrinkles and a small pore diameter of filter paper allow the depositionand arrangement of metal nano particles on paper to form a large-area SERS hot spot. A composite paper-based substrate is formed by reducing and preparing a cellulose nanocrystals-silver (CNC-Ag) composite on the filter paper. Pores in the surface of the filter paper are further filled with a CNC-Ag composite material, and the reproducibility of an SERS sensor is improved. The paper-based substrate is modified with hydrophobic alkyl mercaptan, the modified substrate has a cohesive effect for a sample to be tested, and therefore, the limit of detection of an analyte is improved. That two substances including phenylethanolamine A and metronidazole can be effectively detected by the paper-based SERS substrate is proved, and the limit of detection (LOD) is as low as 5* 10(-9) mol / L and 2*10(-7) mol / L.

Description

technical field [0001] The invention belongs to the technical field of detection, and in particular relates to a hydrophobic paper SERS substrate and a preparation method and application thereof. Background technique [0002] Surface-enhanced Raman scattering (SERS) is a powerful technique for the detection of trace species, which enhances the Raman signal of target molecules adsorbed on or close to noble metal surfaces. It is a highly sensitive, non-destructive and fast analytical method that provides a wealth of information about organic compounds. Traditional solid supports have high reproducibility and sensitivity with suitable nanostructures. Such as glass, silicon and anodized aluminum etc. However, the whole process of manufacturing these substrates is complicated, not environmentally friendly and expensive. Chinese patent number (CN 103257132 B) discloses a silver nanocap array surface-enhanced Raman active substrate and its preparation method. The substrate is a...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 先丽蔡荣源卢玉栋游瑞云吴长机
Owner FUJIAN NORMAL UNIV
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