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Composition for treating depressive disorder complicated by breast cancer, and preparation method and application

A technology for depression and composition, applied in the field of medicine, can solve problems such as unclearness, and achieve the effects of improving drug efficacy, removing unfavorable components, and improving curative effect

Active Publication Date: 2019-11-01
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] It is not clear whether depression is a risk factor for tumor development, but it is related to the poor prognosis of cancer patients

Method used

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  • Composition for treating depressive disorder complicated by breast cancer, and preparation method and application
  • Composition for treating depressive disorder complicated by breast cancer, and preparation method and application
  • Composition for treating depressive disorder complicated by breast cancer, and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The raw materials of the present invention include the following parts by weight: 8 parts of wangbuliuxing, 9 parts of cnidium, 11 parts of American ginseng, 23 parts of motherwort, 8 parts of turmeric and 6 parts of rhodiola. Each raw material component was processed as follows.

[0047] Wangbuliuxing: Take a certain amount of Wangbuliuxing medicinal materials, heat and reflux extract twice with 75% (volume concentration) ethanol with 10 times the amount (volume-to-weight ratio), 1.5h each time, filter, combine the medicinal liquid, and freeze-dry The total extract was obtained. The total extract was taken and extracted with petroleum ether, dichloromethane, ethyl acetate and n-butanol in sequence. The dry powder obtained after freeze-drying each part is the buliuxing extract, which is ready for use.

[0048] Fructus Cnidii: Take the dried Fructus Cnidii medicinal materials and crush them, pass through a 40-mesh sieve, take Cnidium Fructus powder and add an appropria...

Embodiment 2

[0054] Compared with Example 1, the difference is that the proportioning of raw materials is different. The raw materials of Example 2 include the following parts by weight, 4 parts of Wangbuliuxing, 10 parts of Fructus Cnidii, 12 parts of American ginseng, 15 parts of motherwort, 3 parts of turmeric and rhododendron 4 servings per day.

Embodiment 3

[0056] Compared with Example 1, the difference is that the proportioning of raw materials is different. The raw materials of Example 3 include the following parts by weight, 9 parts of Wangbuliuxing, 6 parts of Fructus Cnidii, 8 parts of American ginseng, 28 parts of motherwort, 9 parts of turmeric and rhododendron 6 servings per day.

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Abstract

The invention relates to a composition for treating depressive disorder complicated by breast cancer, and a preparation method and application. The composition is prepared from the following components in parts by weight: 4-9 parts of cowherb seed, 6-10 parts of fructus cnidii, 8-12 parts of American ginseng, 15-28 parts of herbal leonuri, 3-9 parts of rhizome curcumae longae and 4-6 parts of rhodiola. 6 kinds of traditional Chinese medicine component raw materials are adopted, according to the treatment raw materials of the depressive disorder complicated by the breast cancer, aimed at the different raw materials, different effective component extractive methods are adopted, the effect of medicine is exerted at the greatest extent, and compared with the method of direct decoction, the obtained medicine or health care products by the preparation method has the better curative effect. On the one hand, the effect of the various raw material ratio is exerted, on the other hand, by using the preparation method, the content of the effective components in the raw materials is improved, harmful components are removed, and the medicine effect is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition, preparation method and application for treating breast cancer complicated with depression. Background technique [0002] In 1999, Maes proposed the inflammatory response hypothesis of depression, which holds that the activation of the immune system is closely related to depression, that is, the activated peripheral immune system leads to depression-related behavior and neuroendocrine changes by releasing pro-inflammatory cytokines. The hypothesis is also known as the cytokine theory of depression. The chronic inflammatory state of depression can be explained by cytokines secreted by circulating monocytes and macrophages. Studies have shown that the concentration of interleukin-1β (interleukin-1β, IL-1β) in the cerebrospinal fluid of patients with depression increases while the concentration of IL-6 decreases, and the concentration of IL-1 is related t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00A61P25/24
CPCA61K36/234A61K36/258A61K36/36A61K36/41A61K36/533A61K36/9066A61K2236/19A61K2236/333A61K2236/35A61K2236/51A61K2236/55A61P25/24A61P35/00A61K2300/00
Inventor 孟盼王宇红朱青韩远山
Owner HUNAN UNIV OF CHINESE MEDICINE
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