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Potential-type sialic-acid sensor based on molecularly imprinted polymer-modified carbon cloth electrode

A technology for modifying electrodes and carbon cloth electrodes, which is applied to instruments, scientific instruments, analytical materials, etc., to achieve the effects of promoting electron transfer, large specific surface area, and improving sensitivity

Inactive Publication Date: 2019-11-01
SHANGQIU NORMAL UNIVERSITY
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  • Abstract
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  • Potential-type sialic-acid sensor based on molecularly imprinted polymer-modified carbon cloth electrode
  • Potential-type sialic-acid sensor based on molecularly imprinted polymer-modified carbon cloth electrode
  • Potential-type sialic-acid sensor based on molecularly imprinted polymer-modified carbon cloth electrode

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Embodiment 1

[0027] Example 1 Preparation method of potentiometric sialic acid sensor based on molecular imprinting polymerization technology and boronic acid-diol recognition

[0028] Polymerization of aminophenylboronic acid on carbon cloth electrodes: Electrochemical polymerization was performed in 0.1 mM HCl solution containing 20 mM 3-aminophenylboronic acid monomer, 100 mM NaF and 5 mM sialic acid. Electrochemical polymerization uses a carbon cloth electrode as the working electrode, Ag / AgCl as the reference electrode, and performs 30 cycles of cyclic voltammetry scanning in the voltage range of 0.1-1.1V and at a scanning rate of 100mV / s. Soak the modified electrode in 0.1M NaOH solution for 12 hours, so as to elute the sialic acid template molecules on the modified electrode. Finally, soak the electrode in 0.1M phosphate buffer solution (pH4.8) for 24 hours to stabilize the potential. That is, a potentiometric sialic acid sensor was obtained.

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Abstract

The invention discloses a potential-type sialic-acid sensor based on a molecularly imprinted polymer-modified carbon cloth electrode, and belongs to the technical field of novel functional nano composite materials and biosensor detection. The sialic-acid potential-type sensor is constructed through the following method: depositing aminobenzeneboronic acid molecules onto a carbon cloth electrode surface in the presence of sialic acid through electrochemical polymerization, eluting sialic acid, and thus obtaining the molecularly imprinted polymer film-modified electrode. The potential-type sensor shows high sensitivity, good selectivity and long-term stability in sialic-acid measurement and determination. Application of the same to measurement and determination of sialic acid in infant formula milk powder obtains satisfactory results.

Description

technical field [0001] The invention relates to a potentiometric sensor based on molecular imprinting polymerization technology and boronic acid-diol recognition and a preparation method thereof, which is used for the detection of sialic acid, and belongs to the technical field of novel functional nanocomposite materials and biosensor detection. Background technique [0002] Sialic acid is the general term for nine-carbon sugar neuraminic acid derivatives, which widely exist in biological tissues and body fluids, and are located at the end of cell membrane glycolipids and glycoprotein sugar chains. Glycolipids containing sialic acid, called gangliosides, play a very important role in the creation and development of the brain and nervous system. The main food source of sialic acid is breast milk, but it is also found in milk, eggs and cheese. Currently, sialic acid is added to infant formula, however, excessive intake of sialic acid can also trigger inflammation in the body....

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 周艳丽董辉崔斐斐刘澜涛徐茂田
Owner SHANGQIU NORMAL UNIVERSITY
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