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Preparation method of solid imprinted polymer modified QCM-D sensor

A technology for imprinting polymers and sensors, which is applied in the field of preparation of QCM-D sensors to achieve the effect of improving selectivity and specificity and simplifying the operation process

Active Publication Date: 2019-11-12
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a new method for preparing a QCM-D sensor based on solid-phase imprinted polymer modification for the QCM-D detection of targets with complex structures

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  • Preparation method of solid imprinted polymer modified QCM-D sensor

Examples

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Embodiment 1

[0028] A method for preparing a solid-phase imprinted polymer-modified QCM-D sensor, using tetracycline as a target molecule, first immobilizing tetracycline on magnetic ferric oxide particles prepared in the laboratory, and then using the solid-phase matrix as a template molecule , mixed with functional monomers, cross-linking agents, and initiators to prepare a solid-phase imprinted polymer, and modify it onto the surface of a QCM-D chip to obtain a QCM-D sensor modified by a solid-phase imprinted polymer, which specifically includes the following steps:

[0029] 1) Preparation of solid phase matrix: the solid phase matrix used in the present invention is silicon dioxide modified ferric oxide particles. Among them, iron ferric oxide is prepared by the polyol method, and the specific preparation method is as follows: 1.3g of ferric chloride hexahydrate is dissolved in 40mL of ethylene glycol, and after ultrasonic dispersion, 3.2g of anhydrous sodium acetate and 2.0g of polyet...

Embodiment 2

[0038] A method for preparing a solid-phase imprinted polymer-modified QCM-D sensor, using tetracycline as a target molecule, first immobilizing tetracycline on magnetic ferric oxide particles prepared in the laboratory, and then using the solid-phase matrix as a template molecule , mixed with functional monomers, cross-linking agents, and initiators to prepare a solid-phase imprinted polymer, and modify it onto the surface of a QCM-D chip to obtain a QCM-D sensor modified by a solid-phase imprinted polymer, which specifically includes the following steps:

[0039] 1) Preparation of solid phase matrix: the solid phase matrix used in the present invention is silicon dioxide modified ferric oxide particles. Among them, ferric ferric oxide is prepared by polyol method, and then it is modified with silicon dioxide by tetraethyl orthosilicate to obtain ferric ferric oxide particles modified with silicon dioxide. The specific preparation method is the same as that in Example 1.

[0...

Embodiment 3

[0044] A method for preparing a solid-phase imprinted polymer-modified QCM-D sensor, using tetracycline as a target molecule, first immobilizing tetracycline on magnetic ferric oxide particles prepared in the laboratory, and then using the solid-phase matrix as a template molecule , mixed with functional monomers, cross-linking agents, and initiators to prepare a solid-phase imprinted polymer, and modify it onto the surface of a QCM-D chip to obtain a QCM-D sensor modified by a solid-phase imprinted polymer, which specifically includes the following steps:

[0045] 1) Preparation of solid phase matrix: the solid phase matrix used in the present invention is silicon dioxide modified ferric oxide particles. Among them, ferric ferric oxide is prepared by polyol method, and then it is modified with silicon dioxide by tetraethyl orthosilicate to obtain ferric ferric oxide particles modified with silicon dioxide. The specific preparation method is the same as that in Example 1.

[0...

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Abstract

The invention discloses a preparation method of a solid imprinted polymer modified QCM-D sensor. According to the method, first, template molecules are fixed to magnetic ferroferric oxide particles, and a solid matrix is introduced to serve as a template in the preparation process of a molecule imprinted polymer, so that a solid imprinted polymer is obtained; then, the prepared imprinted polymer is adopted to modify a quartz crystal microbalance (QCM) sensor; and last, the sensor is successfully applied to specificity recognition of tetracycline. The preparation method has the advantages thatthe molecule imprinted polymer template prepared by the adoption of a solid imprinting technology is easy to elute, and meanwhile a large quantity of imprinting sites are gathered on a surface to achieve the purpose of improving imprinted polymer recognition capability. By the adoption of the solid imprinted polymer modified QCM-D sensor, low-concentration target molecules (for example, 50-300ng / mL tetracycline) can be selectively recognized.

Description

technical field [0001] The invention belongs to the technical field of molecular detection based on QCM-D, and relates to a preparation method of a QCM-D sensor based on solid-phase imprinted polymer modification. Background technique [0002] Quartz crystal microbalance (QCM) is a quality detection device made according to the piezoelectric effect produced by its quartz crystal, which can change the quality change of the QCM chip into a frequency change, so as to achieve high-precision detection of mass and concentration, etc. For varying purposes, its precision can reach the nanogram level. The difference between QCM-D and traditional QCM is that it monitors the change of the dissipation factor while monitoring the frequency change, so it can analyze the change of the surface of the QCM chip more comprehensively. However, like the traditional QCM technology, its application in the field of quantitative detection is limited due to the lack of selectivity on the surface of ...

Claims

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Application Information

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IPC IPC(8): G01N5/02
CPCG01N5/02
Inventor 胡玉峰邢瀚文刘名扬宋芳漪吴明火柳丽芬
Owner DALIAN UNIV OF TECH
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