Immunochromatographic assay system, sample imaging method and sample image analysis method

An immunochromatographic detection and analysis method technology, applied in the analysis of materials, material excitation analysis, material analysis by optical means, etc., can solve the problems of few detection channels, low measurement efficiency, single data transmission method, etc., to reduce manpower. The effect of cost, reduction of sample and reagent usage, and simplified operation process

Pending Publication Date: 2019-11-12
ACADEMY OF MILITARY MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The object of the present invention is to provide an immunochromatography detection system, a sample imaging method and a sample image analysis method, so as to solve the problem of fewer detection channels, single data transmission mode, unit Problems such as low time measurement efficiency

Method used

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  • Immunochromatographic assay system, sample imaging method and sample image analysis method
  • Immunochromatographic assay system, sample imaging method and sample image analysis method
  • Immunochromatographic assay system, sample imaging method and sample image analysis method

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Embodiment 1

[0051] This embodiment provides an immunochromatographic detection system, wherein: figure 1 An exploded view of the internal structure of the immunochromatographic detection system provided in Example 1 of the present invention.

[0052] Such as figure 1 As shown, the immunochromatographic detection system includes a housing 1 and a laser light source arranged in the housing 1, a test paper mount 4, a chromatography test strip 5 and a camera (not marked); the chromatography test strip 5 is placed on the test paper On the mounting base 4, the chromatography test strip 5 is used to set the capture antibodies of multiple biomarkers to be tested, and the detection antibodies of the multiple biomarkers to be tested are respectively marked by quantum dot microspheres of different colors; The light is used to irradiate the chromatography test strip 5, the quantum dot microsphere immune complexes of multiple biomarkers to be tested generate fluorescent signals of different colors un...

Embodiment 2

[0054] This embodiment provides an immunochromatographic detection system, wherein: figure 2 An exploded view of the internal structure of the immunochromatographic detection system provided in Example 2 of the present invention.

[0055] Such as figure 2 As shown, the immunochromatography detection system of this embodiment has the same basic structure as that of Embodiment 1. Further, the laser light source includes an ultraviolet light source 2 and an excitation filter 3; the excitation filter 3 is arranged on the chromatography test paper Between bar 5 and UV light source 2.

[0056] In the above embodiment, the excitation filter 3 can filter the available light, reduce the light directly irradiating the chromatography test strip 5, reduce the background interference, and improve the detection signal-to-noise ratio.

Embodiment 3

[0058] This embodiment provides an immunochromatographic detection system, wherein: image 3 An exploded view of the internal structure of the immunochromatographic detection system provided in Example 3 of the present invention.

[0059] Such as image 3 As shown, the basic structure of the immunochromatographic detection system of this embodiment is the same as that of Embodiment 1 or 2, and further includes a power supply assembly 7; the power supply assembly 7 is arranged in the casing 1 and is electrically connected to the laser light source.

[0060] In the above embodiments, compared with the external power supply, the power supply assembly 7 is arranged in the housing 1 to facilitate the movement of the device. Specifically, the power supply assembly 7 can choose to use a fuel cell or a rechargeable battery, which is small in size and easy to maintain and replace.

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Abstract

The invention provides an immunochromatographic assay system. The system comprises a housing and a laser light source, a test strip mounting base, a chromatographic test strip and a camera arranged inthe housing; the chromatographic test strip is placed on the test strip mounting base, the light produced by the laser light source is used to irradiate the chromatographic test strip, and the camerais used to capture a fluorescent signal generated after the chromatographic test strip is irradiated. According to the immunochromatographic assay system of the invention, the laser light source is used to irradiate quantum dot microspheres that are labeled by detection antibodies of various biomarkers and have different colors, a plurality of biomarkers can be simultaneously detected at one timeand imaged for data analysis, and the detection process is accurate and efficient. Based on the operation, the invention also provides a sample imaging method and a sample image analysis method basedon the above immunochromatographic assay system.

Description

technical field [0001] The invention relates to the technical field of medical research and application, in particular to an immunochromatography detection system, a sample imaging method and a sample image analysis method. Background technique [0002] Point-of-care testing (POCT) refers to a new method of clinical testing performed next to the patient, which can be analyzed in real time at the sampling site, and does not require complex laboratory sample processing to obtain test results. Due to the characteristics of fast speed, simple use, and low cost, POCT detection methods have become more and more widely used in the detection of biomarkers in the field of clinical detection. [0003] Immunochromatographic detection method is considered to be one of the most commonly used analytical methods in the field of POCT. Because its immunological characteristics are unique to physiology, it has an absolute advantage and status in the field of rapid detection. [0004] Most of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/558G01N21/64
CPCG01N33/558G01N21/6402G01N21/6428G01N21/6456
Inventor 王升启荣振肖瑞
Owner ACADEMY OF MILITARY MEDICAL SCI
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