A kind of preparation method of sustained-release preparation containing ibuprofen pellets

Abstract

The invention belongs to the technical field of preparation of medicines, and particularly relates to a preparation method of a slow release preparation containing ibuprofen mini-pills. The preparation method comprises the steps of adding raw materials of ibuprofen powder and microcrystalline cellulose into a material mixer, and performing sufficient and uniform stirring to obtain mixed raw materials; jointly placing dissolving liquid and hydroxypropyl methylcellulose in the raw materials into the material mixer, performing stirring, and in the process of stirring, adding the hydroxypropyl methylcellulose so that the hydroxypropyl methylcellulose completely dissolves in the dissolving liquid to obtain paste type substances which can be sprayed out through a spray head to be used as an adhesive; and spraying a part of the dissolving liquid onto the surfaces of the mixed raw materials, performing baking on the mixed raw materials at high temperature of 20-35 DEG C for 5-10 minutes, putting the baked raw materials into a pelletizing machine, uniformly sprinkling the adhesive onto the surfaces of the mixed raw materials through an automatic spray head, and performing centrifuging to obtain the mini-pills. According to the preparation method disclosed by the invention, the medicine effects of ibuprofen can be enhanced, the constitutions and the immunity of patients can be enhanced,and the patients can be assisted for rehabilitation; and besides, citrus skin and dried lily bulb powder can adjust the mouth feel of the pills, so that aged people can be assisted for swallowing theslow release preparation, and the medical speciatity can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a preparation method of a slow-release preparation containing ibuprofen pellets. Background technique [0002] Rheumatoid arthritis is a common acute or chronic inflammation of connective tissue. Can be recurrent and involve the heart. Clinical one is characterized by migratory soreness, heaviness, and pain in joints and muscles. An allergic disease. It is one of the main manifestations of rheumatic fever, mostly with acute fever and arthralgia onset. [0003] Rheumatoid arthritis is a manifestation of rheumatic fever. Rheumatic fever is a systemic allergic disease caused by group A beta-hemolytic streptococcus infection, and there are often infection medical histories such as erysipelas at the beginning of the disease. Rheumatic fever has an acute onset, and rheumatic arthritis can invade the heart, causing rheumatic heart disease, and performances such as heat...

AI Technical Summary

Problems solved by technology

[0006] In order to make up for the deficiencies of the existing technology, solve the problems that the elderly have difficulty swallowing after the medicine is made into capsules, the smell of the medicine is irritating after the capsule dissolves, causing the patient to vomit, reducing the therapeutic effect of the medicine, unstable drug concentration, frequent taking of medicine, large side effects and long recovery time. , a kind of preparation method of the sustained-release preparation containing ibuprofen pellet proposed by the present invention

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