Degradable medical polymer material and preparation method thereof

A technology for polymer materials and raw materials, applied in the field of degradable medical polymer materials and their preparation, can solve the problems that need to be further improved, and achieve the effects of excellent degradable performance, abundant raw material sources, and excellent mechanical and mechanical properties.

Inactive Publication Date: 2019-11-15
周青英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition of the biodegradable medical material is: 100-120 parts by mass of modified polylactic acid, 60-80 parts of polycarbonate fiber, 4-8 parts of reinforcing agent, 1-2 parts lubricant, 2-5 parts of toughening agent, 2-3 parts of dispersant, 1-2 parts of antioxidant; the medical material has excellent performance, high strength, corrosion resistance, can be degraded by itself, and will not cause environmental pollution harm, and its preparation method is simple, suitable for large-scale production and application, but this material has more additives, and the compatibility between the components and the comprehensive performance of the material need to be further improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A degradable medical polymer material, characterized in that it is made of the following parts by weight of raw materials: 30 parts of vinyl-modified star polylactic acid, 3 parts of diacetone acrylamide, 3 parts of 1-vinylimidazole, and 10 parts of vinyl hyperbranched polyester, 25 parts of vinyl-terminated polycaprolactone diol 2,5-furandicarboxylic acid polycondensate, and 1 part of azobisisobutyronitrile.

[0026] The preparation method of the vinyl-terminated polycaprolactone diol 2,5-furandicarboxylic acid polycondensate includes the following: adding polycaprolactone diol and 2,5-furandicarboxylic acid to dimethyl sulfoxide Form a solution, then dissolve in the polymerization reactor, seal, reflux at 220 ℃ for 3 hours for esterification, then add antimony trioxide, reduce the pressure to 100 Pa, and polycondensate at 240 ℃ for 12 hours. Then add tetrachlorobenzoquinone and isopentenol to it, continue the heat preservation reaction for 1 hour, then cool to room tempe...

Embodiment 2

[0029] A degradable medical polymer material, characterized in that it is made of the following parts by weight of raw materials: 33 parts of vinyl-modified star polylactic acid, 4 parts of diacetone acrylamide, 4 parts of 1-vinylimidazole, terminal 11 parts of vinyl hyperbranched polyester, 27 parts of vinyl-terminated polycaprolactone diol 2,5-furandicarboxylic acid condensation polymer, 1.2 parts of azobisisoheptonitrile.

[0030] The preparation method of the vinyl-terminated polycaprolactone diol 2,5-furandicarboxylic acid polycondensate includes the following: adding polycaprolactone diol and 2,5-furandicarboxylic acid to N,N-dicarboxylic acid Form a solution in methylformamide, then add it to the polymerization reactor, seal it, reflux at 225℃ for 3.3 hours for esterification, then add antimony acetate, reduce the pressure to 150Pa, and polycondensate at 242℃14 After hours, add 1,4-naphthoquinone and isopentenol to it, continue to heat and react for 1.2 hours, then cool to...

Embodiment 3

[0033] A degradable medical polymer material, characterized in that it is made of the following parts by weight of raw materials: 35 parts of vinyl-modified star-shaped polylactic acid, 4.5 parts of diacetone acrylamide, 4.5 parts of 1-vinylimidazole, terminal 13 parts of vinyl hyperbranched polyester, 30 parts of vinyl-terminated polycaprolactone diol 2,5-furandicarboxylic acid polycondensate, 1.5 parts of lauroyl peroxide.

[0034] The preparation method of the vinyl-terminated polycaprolactone diol 2,5-furandicarboxylic acid polycondensate includes the following: adding polycaprolactone diol and 2,5-furandicarboxylic acid to N-methylpyrrolidone Then it was dissolved in the polymerization reactor, sealed, and refluxed at 230°C for 3.5 hours for esterification. Then, ethylene glycol antimony was added, the pressure was reduced to 200Pa, and the polycondensation reaction was carried out at 245°C for 16 hours. Then add p-hydroxyanisole and prenol to it, continue to keep the temper...

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PUM

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Abstract

The invention discloses a degradable medical polymer material. The degradable medical polymer material is prepared from, by weight, 30-40 parts of vinyl-modified star polylactic acid, 3-6 parts of diacetone acrylamide, 3-6 parts of 1-vinylimidazole, 10-15 parts of a vinyl-terminated hyperbranched polyester, 25-35 parts of a vinyl-terminated polycaprolactone diol and 2,5-furandicarboxylic acid condensation polymer and 1-2 parts of an initiator. The invention also discloses a preparation method of the degradable medical polymer material. The degradable medical polymer material disclosed in the invention has the advantages of good tissue applicability, good degradable metabolism ability, stable quality, excellent mechanical properties, and effectiveness in killing pathogens to prevent the breeding of pathogens.

Description

Technical field [0001] The invention relates to the technical field of medical materials, in particular to a degradable medical polymer material and a preparation method thereof. Background technique [0002] With the rapid economic development and continuous advancement of science and technology, my country's medical and health services have also made great progress, providing a strong guarantee for the improvement of people's physical fitness. These achievements have led to the rapid development of medical polymer materials. With the continuous expansion of the application range of medical polymer materials and people’s urgent need to improve the level of medical treatment, higher requirements are put forward for the performance of medical polymer materials. Biodegradable medical polymer materials are one of which meets people’s needs. And high value-added medical polymer materials are widely used in the production of medical equipment such as syringes, slings, infusion tubes, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F283/01C08F220/58C08F226/06
CPCC08F283/01C08F220/58C08F226/06
Inventor 不公告发明人
Owner 周青英
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