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Method for extracting cerebroside from gynura procumbens and application of cerebroside

A technology of flat lying chrysanthemum notoginseng and cerebroside, which is applied in the field of cerebroside, can solve the problems of insufficient research on functional ingredients and their mechanism of action, and achieve excellent anti-inflammatory activity, easy access, and high purity

Active Publication Date: 2019-11-19
江西华紫仁农业开发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, the research on its functional components and its mechanism of action is not deep enough.

Method used

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  • Method for extracting cerebroside from gynura procumbens and application of cerebroside
  • Method for extracting cerebroside from gynura procumbens and application of cerebroside
  • Method for extracting cerebroside from gynura procumbens and application of cerebroside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take 1000g of crushed chrysanthemum panax notoginseng leaves, add 80% ethanol aqueous solution in volume percentage according to the material-to-liquid ratio of 1g:10mL, ultrasonic extraction 3 times, ultrasonic power is 50W, frequency is 20KHz, extraction temperature is 40℃, The extraction time is 20 minutes, and the extract is obtained, then filtered and concentrated under reduced pressure to form a crude extract; a small amount of water is added to the crude extract and ultrasonically shaken to form a suspension, and then extracted with n-butanol / chloroform, n-butanol The volume ratio to chloroform is 3:1, the number of extractions is 3, and the extract is concentrated under reduced pressure to form the extracted extract; the extracted extract is dissolved in a methanol solution with a volume concentration of 10% to obtain a preliminary purification of the extract The methanol solution of the product, the methanol solution of the preliminary purified product of the ext...

Embodiment 2

[0046] Take 2000g of pulverized chrysanthemum notoginseng leaves, add a 70% ethanol aqueous solution with a volume percentage of 1g:20mL according to the material-to-liquid ratio, and ultrasonically extract 3 times. The ultrasonic power is 50W, the frequency is 20KHz, and the extraction temperature is 40℃. The extraction time is 20 minutes, and the extract is obtained, then filtered and concentrated under reduced pressure to form a crude extract; a small amount of water is added to the crude extract to ultrasonically shake into a suspension, and then extracted with n-hexane / methanol, the volume of n-hexane and methanol The ratio is 4:1, the number of extractions is 3 times, and the extract is concentrated under reduced pressure; the obtained extract is dissolved in a methanol solution with a volume concentration of 8% to obtain a methanol solution of the preliminary purified product of the extract. The methanol solution of the preliminary purified product of the extract is separ...

Embodiment 3

[0048] Take 1500g of pulverized chrysanthemum panax notoginseng roots, add 50% ethanol aqueous solution in volume percentage according to the material-to-liquid ratio of 1g:10mL, and ultrasonically extract 4 times. The ultrasonic power is 70W, the frequency is 23KHz, and the extraction temperature is 45℃. The extraction time is 30 minutes, and the extract is obtained, then filtered and concentrated under reduced pressure to form a crude extract; a small amount of water is added to the crude extract to ultrasonically shake into a suspension, and then dichloromethane / methanol is used for extraction, dichloromethane and methanol The volume ratio of the extract is 2:1, the number of extractions is 3 times, and the extract is concentrated under reduced pressure to form the extracted extract; the extracted extract is dissolved in a methanol solution with a volume concentration of 15% to obtain a methanol solution of the preliminary purified product of the extract The methanol solution...

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Abstract

The invention belongs to the technical fields of separation and purification of natural products, and discloses a method for extracting cerebroside from gynura procumbens. According to the method provided by the invention, the gynura procumbens is used as a raw material, and through the steps of two-phase solvent mixed extraction, column chromatography, crystallization and the like, the novel cerebroside can be quickly separated from the gynura procumbens; the product obtained by the method has high purity, natural molecules are not destroyed, and the product is suitable for large-scale production; and the obtained cerebroside has excellent anti-inflammatory activity and can be used for developing related anti-inflammatory drugs.

Description

Technical field [0001] The invention belongs to the technical field of separation and purification of natural products, and in particular relates to a method for extracting cerebrosides from Panax notoginseng and the use of cerebrosides. Background technique [0002] Gynura procumbens (Lour.) Merr. is a plant belonging to the Compositae family and a genus of Panax notoginseng. It is also known as Panax notoginseng, Snake Bone, Suspension Grass, and Fairy Grass. Perennial herbaceous medicinal and edible plants, widely distributed in China, Malaysia, Thailand, Indonesia, South Korea and the Philippines. Panax notoginseng has a wide range of pharmacological effects. In the first half of 2009, the Chinese Center for Disease Control and Prevention, the National Food Quality Supervision and Inspection Center, the China Food and Fermentation Industry Research Institute and other relevant units completed the toxicological inspection and hygiene of Panax notoginseng. The conclusion is: n...

Claims

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Application Information

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IPC IPC(8): C07H1/08C07H15/10A61P29/00
CPCA61P29/00C07H1/08C07H15/10
Inventor 吴磊胡居吾熊伟韩晓丹涂招秀黄斌华
Owner 江西华紫仁农业开发有限公司
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