Drug-loaded bacterial outer membrane vesicle,and preparation method and application thereof

A technology of outer membrane vesicles and bacteria, which can be used in antibacterial drugs, pharmaceutical formulations, microcapsules, etc., and can solve the problems of less research
CN110478331AActive Publication Date: 2019-11-22MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Publication Date
2019-11-22

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Abstract

The invention discloses a drug-loaded bacterial outer membrane vesicle, and a preparation method and application thereof, and particularly relates to a drug-loaded bacterial outer membrane vesicle prepared with the aid of liposome and a preparation method and application of the drug-loaded bacterial outer membrane vesicle. The application is in particular application in the preparation of antibacterial drugs. The invention provides the method for preparing a preparation containing the drug-loaded bacterial outer membrane vesicle, the method comprises the following steps of taking a preparationcontaining a drug-loaded liposome and a preparation containing a bacterial outer membrane vesicle as raw materials, and preparing to obtain the preparation containing the drug-loaded bacterial outermembrane vesicle. The invention further provides the method for preparing the drug-loaded bacterial outer membrane vesicle, the method comprises the following steps of taking a drug-loaded liposome and a bacterial outer membrane vesicle as raw materials, and preparing to obtain the drug-loaded bacterial outer membrane vesicle. The invention further provides the antibacterial drugs, including the preparation containing the drug-loaded bacterial outer membrane vesicle or the drug-loaded bacterial outer membrane vesicle. According to the drug-loaded bacterial outer membrane vesicle, the preparation method and application thereof, broad application prospects in the field of drug delivery and the field of antibacterial drug development achieved.
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Description

technical field

[0001] The present invention relates to a drug-loaded bacterial outer membrane vesicle and its preparation method and application, in particular to a drug-loaded bacterial outer membrane vesicle prepared by means of liposomes and its preparation method and application. Application of antibacterial drugs. Background technique

[0002] Bacterial outer membrane vesicles, which are evolutionarily conserved, are nanoscale functional vesicles released by bacteria to the outside world. They were first discovered in 1967 by Chatterjee et al. Outer membrane vesicle, OMV). The structure of OMV is similar to that of liposome, its diameter is usually between 20-300nm, the main body is phospholipid bilayer, in addition, it also includes bacterial outer membrane and periplasmic components, such as periplasmic protein, outer membrane protein, cytoplasmic protein, Peptidoglycan, lipopolysaccharide, DNA, RNA, various enzymes related to virulence, etc. All Gram-negative bac...

Claims

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