Process for preparing thioesters from oxothioglycolic acid compounds
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology for thioglycolic acid and compounds, which is applied in the field of palladium-catalyzed preparation of thioesters by oxothioglycolic acid compounds, can solve problems such as complicated operations, and achieve the effects of simple operations, simplified processing methods, and optimized synthesis strategies.
Active Publication Date: 2021-08-13
UNIV OF SCI & TECH OF CHINA
View PDF2 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
This scheme often requires the participation of heating and higher pressure carbon monoxide, but the industrial operation of the high temperature, high pressure and highly toxic system is more complicated
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The present invention provides a method for preparing thioesters from oxothioglycolic acid. In the presence of a palladium catalyst, a phosphine ligand and an organic solvent, the corresponding thioester is generated by decarboxylation of an oxythioglycolic acid compound and reaction with an aryl iodide / aryl bromide or a compound containing an unsaturated bond. The method provided by the invention can realize high-efficiency catalytic conversion at room temperature or under heating, the reaction conditions are mild, the operation is simple, no additional additives such as alkali are used, the treatment method is simplified, and it meets the requirements of developing green and environment-friendly chemistry. The scope of substrates And functional group compatibility has universal applicability and high chemoselectivity. And this method can be successfully applied to the scheme of functional group modification of complex molecules to optimize the synthesis strategy of some drug molecules, improve the synthesis efficiency and reduce the cost, which has industrial synthesis value and prospect.
Description
technical field [0001] The invention relates to the field of compound synthesis, in particular to a palladium-catalyzed method for preparing thioesters through oxothioglycolic acid compounds. Background technique [0002] Thioester is a very important class of synthetic intermediates in organic chemistry. Through further functionalization reactions, sulfur atoms and carbonyl groups can be easily introduced into various structures, which will greatly change the physical and chemical properties of the compound and can be applied to Activation modification of various bioactive molecules and other fields. In addition, the high reactivity of sulfur atoms and carbonyl groups is also widely used in the field of synthesis, which makes thioesters an organic molecule with high synthetic value. [0003] At present, the main scheme for the construction of thioesters is the carbonyl intercalation system of thiol-carbon monoxide: under the catalysis of transition metals, thiol, carbon mo...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more