Complex mixed and wrapped dual-response release sterilization material and preparation method thereof

Abstract

The invention relates to preparation of response release materials, in particular to a dual-response release sterilization material based on mixed wrapping of gelatin and Cu-BTA complex and a preparation method thereof. Halloysite nanotubes and a gelatin solution with a dispersed complex are mixed and subjected to cross-linking treatment under the action of a cross-linking agent, and the precipitate is collected, thus obtaining a complex mixed wrapping material. The release material prepared according to the invention makes use of the sulfur ions and hydrogen ions released by common sulfate reducing bacteria and some acid-producing bacteria in a metabolic process in the environment as signal molecules, and based on the point, the dual-response release material based on mixed wrapping of gelatin and Cu-BTA complex can be obtained. The principle of response release lies in that sulfur ions can take away Cu ions to form CuS precipitate, thus destroying a Cu-BTA film layer in a mixture wrapping layer; under the acidic condition, a gelatin film layer can be protonated, thus avoiding rejecting protonated halloysite nanotubes, and when the gelatin layer is dissociated, a bactericide is released. The preparation method for constructing the drug loading system is simple, and has strong pertinence.

Description

technical field [0001] The invention relates to the preparation of a response release material, in particular to a double response release bactericidal material based on gelatin and Cu-BTA complex mixed coating and a preparation method thereof. Background technique [0002] The corrosion loss caused by microbial corrosion accounts for about 20% of the total corrosion loss, and is an important factor causing accelerated damage to marine engineering facilities. The main corrosion microorganisms include iron bacteria, sulfate-reducing bacteria, and acid-producing bacteria. [0003] The control methods for these corrosive microorganisms are mainly chemical methods, and the traditional chemical control method is to put fungicides into the environment. The side effects of this measure are also obvious, which will lead to the destruction of the environment and ecology, and enhance the resistance of bacteria . Later, people found that by coating the fungicide into the porous materi...

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Problems solved by technology

[0003] The control methods for these corrosive microorganisms are mainly chemical methods, and the traditional chemical control method is to put fungicides into the environment. The side effects of this measure are also obvious, which will lead to the destruction of the environment and ecology and enhance the drug resistance of bacteria.

Later, people found that by coating the fungicide into the porous material, it can play a certain slow-release effect and prolong the service life of the material, but because this kind of slow-release is not targeted, it will cause damage to the coated fungicide. waste

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