Application of elemicin in medicine

A technology of elemin and drugs, which is applied in the direction of drug combination, cardiovascular system diseases, ether/acetal active ingredients, etc., can solve problems such as unsatisfactory results, reduce the size of cerebral infarction, and reduce oxidative damage , the effect of broad clinical application prospects

Pending Publication Date: 2019-12-03
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, neuroprotective therapy and thrombolytic therapy are the two major intervention strategies for stroke, but the results are not satisfactory. Therefore, finding effective drugs for the prevention and treatment of cerebral ischemia-reperfusion injury has become an urgent problem to be solved.

Method used

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  • Application of elemicin in medicine
  • Application of elemicin in medicine
  • Application of elemicin in medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 of the present invention discloses a drug for preventing and treating ischemic stroke, which specifically includes the following raw materials in parts by mass: 1 part of elemin, 90 parts of starch, 3 parts of low-substituted hydroxypropyl cellulose, 2 parts of 1 part magnesium stearate, 2 parts sodium lauryl sulfonate, 2 parts hydroxypropyl butyl ester and 2 parts 50% ethanol in water.

[0049] The specific preparation method is:

[0050] Take 1 part of elemin, add 90 parts of starch, 3 parts of low-substituted hydroxypropyl cellulose, 2 parts of magnesium stearate, 2 parts of sodium laurylsulfonate and 2 parts of hydroxypropyl butyl ester, mix well, and use 50% ethanol aqueous solution is used as a binder, wet granulated, dried at a low temperature of 40° C., and then sieved with a 14-mesh sieve to obtain the pharmaceutical composition granules of the present invention.

Embodiment 2

[0052] Embodiment 2 of the present invention discloses a medicine for preventing and treating ischemic stroke, which specifically includes the following raw materials in parts by mass: 40 parts of elemin, 40 parts of lactose, 10 parts of sodium carboxymethyl starch, 5 parts of hard Magnesium steatate, 5 parts cinnazone and 5 parts water.

[0053] The specific preparation method is:

[0054] Take 40 parts of elemin, add 40 parts of lactose, 10 parts of sodium carboxymethyl starch, 5 parts of magnesium stearate and 5 parts of salicylic acid. After drying, 14 mesh sieves are sized and tabletted to obtain the pharmaceutical composition tablet of the present invention.

Embodiment 3

[0056] Embodiment 3 of the present invention discloses a medicine for preventing and treating ischemic stroke, which specifically includes the following raw materials in parts by mass: 90 parts of elemin, 4 parts of castor oil for injection, 4 parts of polyethylene glycol, 1 1 part lauroazepam and 1 part hypromellate.

[0057] The specific preparation method is:

[0058] Take 90 parts of elemin, add 4 parts of castor oil for injection, 4 parts of polyethylene glycol, 1 part of laurocapram and 1 part of hypromellate, mix well, and obtain the pharmaceutical composition injection of the present invention .

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Abstract

The invention discloses an application of elemicin in preparation of a medicine for preventing and treating cerebral arterial thrombosis. The animal experiments prove that the compound elemicin can effectively improve the neurological function score, reduces cerebral infarction area, and improves relevant antioxidant capacity indexes; and the results show that the compound elemicin has a protective effect on cerebral ischemia-reperfusion injury, can effectively prevent and treat cerebral injury caused by cerebral ischemia, and provides a new research direction for the preparation of cerebral ischemia injury related drugs; the invention also discloses the medicine for preventing and treating cerebral arterial thrombosis, which comprises elemicin and pharmaceutically acceptable auxiliary materials, the nerve function can be effectively improved, the cerebral infarction area is reduced, oxidative damage is improved, and the application effect is excellent.

Description

technical field [0001] The invention relates to the technical field of elemin application, and more specifically relates to the application of elemin in medicines for preventing and treating ischemic stroke. Background technique [0002] Elemisin, whose English name is Elemicin, and whose chemical name is 5-allyl-1,2,3-trimethoxybenzene, is a new type of anesthetic, and its structural formula is as follows: [0003] [0004] Elemin is composed of natural oils and belongs to volatile oils. It is a colorless oily liquid. It is widely distributed in food, dietary supplements and many medicinal plants, but the content is small and the extraction is relatively difficult. Current studies have confirmed that elemin can enter brain tissue through the blood-brain barrier, but there is no report on the relationship between elemin and stroke neuroprotection. [0005] Stroke is an important disease whose main clinical manifestation is cerebral ischemia or hemorrhagic injury, 80% of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61P9/10A61P25/00
CPCA61K31/09A61P9/10A61P25/00
Inventor 马学琴杨玲玲李楠李艳婷赵小军张波刘菁菁唐琪雯杨萍萍
Owner NINGXIA MEDICAL UNIV
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