A group of brain proteins whose expressions are regulated by drug dl-PHPB
A histone, dl-phpb technology, applied in the medical field, can solve the problem of inability to prepare injection dosage forms
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[0007] The present invention will be described in detail below in combination with specific embodiments.
[0008] 1. Experimental animals
[0009] Male B6C3-Tg (APPswe, PSEN1dE9) 85Dbo / J (APP / PS1) transgenic mice, wild-type (WT) mice of the same age, were purchased from Jackson Lab in the United States, and were kept in the model animal center of Nanjing University. Breeding, Breeding and genotyping. When the mice are bred to 9 months old, they are airlifted to the experimental center in clean packaging, and placed in a cage for every 3-5 mice. The room temperature is kept at 24±1°C and the humidity is 50-60%. :00 light, 20:00-8:00 the next day closed care, free to eat and drink.
[0010] 2. Experimental method
[0011] Animals were randomly divided into 5 groups, 8-10 in each group, respectively control group (WT mice), model group (APP / PS1 mice) and dl-PHPB treatment group (APP / PS1 mice), memantine treatment group group (APP / PS1 mice), donepezil treatment group (APP / PS1 ...
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