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A method of preparing pellets by wet granulation

A technology of wet granulation and wet granulator, which is applied in the direction of making medicines into special physical or ingestible devices, pharmaceutical formulas, medical preparations of non-active ingredients, etc., and can solve the problem of wet granulation and fluidization Problems such as bed waiting consumption, space, increase of operators and energy, and product cost increase have been achieved to reduce energy consumption, improve production efficiency, and increase production capacity.

Active Publication Date: 2022-05-03
BEIJING GOLDENTEAM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is not difficult to find from the above that the granulation time of the oscillating granulator is more than three times that of other processes, so that when the whole system is working, the wet granulator and the fluidized bed are waiting for wear and tear.
If the number of swing pellet machines is increased, the space, operators and energy will increase exponentially, and the cost of the product will increase accordingly.
As mentioned above, the oscillating granulator has become the bottleneck of the traditional granulation process, but there is no equipment and process that can replace the sizing of the swaying granulator in the prior art, and the above-mentioned sizing process cannot be avoided. The problem

Method used

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  • A method of preparing pellets by wet granulation
  • A method of preparing pellets by wet granulation
  • A method of preparing pellets by wet granulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] According to the first formula (sometimes referred to as formula 1), weigh 61.0kg of starch, 66.6kg of dextrin, 13.4kg of amber powder, and 80.0kg of extract (water content is 30% by mass). Add it to the wet granulator, dry mix for 3 minutes, then add the extract, increase the linear speed of the stirring blade to 1.5m / s, and increase the linear speed of the chopping knife to 7.2m / s to obtain the material to be granulated , and its viscosity is 215cP. Then the material to be granulated is granulated, and the granulation time is increased to 180 seconds to make the final granules. The time of adding materials and the time of discharging are unchanged, wherein the time of adding materials is still 7 minutes, and the time of discharging is still 6 minutes. The wet granulation time is about 18 minutes, and the moisture content of the wet material is 15%. At the same time of wet granulation and discharge, the material falls into the fluidized bed for drying by its own weigh...

Embodiment 2

[0062] According to another formula (sometimes referred to as formula 2), 98.5 kg of powdered sugar, 1.26 kg of paracetamol, 20.1 kg of chlorpheniramine maleate, and 11.7 kg of extract (water content 48% by mass) were weighed. Add sugar powder, acetaminophen, and chlorpheniramine maleate to the wet granulator, dry mix for 3 minutes, then add the extract, increase the linear speed of the stirring blade to 1.17m / s, and chop the knife The linear velocity was increased to 6m / s, and the material to be granulated was obtained, and its viscosity was 263cP. Then the material to be granulated is granulated, and the granulation time is increased to 60 seconds to make the final granules. The time of adding materials and the time of discharging are unchanged, wherein the time of adding materials is still 6 minutes, and the time of discharging is still 5 minutes. The wet granulation time is about 15 minutes, and the moisture content of the wet material is 6.6%. At the same time of wet gra...

Embodiment 3

[0073] Carried out in substantially the same manner as in Example 1, except that the wet granulation parameters were not changed and directly dried in the fluidized bed. The formula is 61.0kg of starch, 66.6kg of dextrin, 13.4kg of amber powder and 80.0kg of extract. First add starch, dextrin, and amber powder to the wet granulator, dry mix for 3 minutes, then add the extract, set the linear speed of the stirring paddle to 1.17m / s, and the linear speed of the chopping knife to 4m / s, and then granulate 90 seconds. The time for adding materials is 7 minutes, the time for discharging materials is 6 minutes, the total wet granulation time is about 17.5 minutes, and the moisture content of wet materials is 15%. At the same time of wet granulation discharge, the material falls into the fluidized bed for drying by its own weight. Because the initial particle size of wet granulation is uneven, most of them are unqualified particles, and the material collapses many times in the fluidi...

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Abstract

The invention relates to a method for preparing granules by wet granulation, comprising: (1) mixing components together according to the formula to obtain materials to be granulated; (2) preparing the granules by wet granulation The granular material is prepared into a granular material to be dried with a specified particle size range; (3) drying the granular material to be dried to obtain a dry granular material; (4) screening out qualified granular material and Unqualified pellets, and re-use the unqualified pellets to prepare subsequent batches of materials to be granulated. The method of the invention can directly dry without granulation, simplifies the granulation process, reduces energy consumption, avoids waste of materials, saves production costs, improves production capacity, and finally improves economic benefits.

Description

technical field [0001] The invention belongs to the technical field of granulation, and in particular relates to a method for preparing granules through a wet granulation method. Background technique [0002] At present, in the pharmaceutical industry, there are many methods of granulation, but the process flow of wet granulator, oscillating granulator, fluidized bed drying and vibrating sieving machine is mainly used for granulation (see figure 1 ). The granules produced by the wet granulation drying process are mainly used for granules or tabletting; the characteristics of the wet granulation drying process are that the granulation time is short and the granules are irregular. They need to be sized by a swing granulator before entering the fluidized bed for processing. Drying, the dried material is then separated from the qualified material, coarse particles and fine powder by a vibrating sieving machine. [0003] In the pharmaceutical industry, some materials have high ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J3/00A61K9/16A61K47/36A61K47/46A61K47/26A61K31/167A61K31/4402
CPCA61J3/00A61K9/1682A61K9/1652A61K9/1664A61K9/1623A61K31/167A61K31/4402
Inventor 邵天君
Owner BEIJING GOLDENTEAM TECH
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