Poly(phthalazinone ether nitrile) having antibacterial properties, and surface modification method of poly(phthalazinone ether nitrile) having antibacterial properties

A technology of naphthalene biphenyl polyarylene ether and polyarylene ether nitrile is applied in the field of antibacterial materials containing naphthalene biphenyl structure polyarylene ether nitrile and the preparation thereof, achieving simple modification method, broad application prospects, and improved biological Compatibility and effect of antibacterial activity

Active Publication Date: 2019-12-20
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of biocompatibility and antibacterial properties of polyarylene ether nitriles in the prior art, the object of the invention is to provide a polyarylene ether nitrile with antibacterial properties and its surface modification method

Method used

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  • Poly(phthalazinone ether nitrile) having antibacterial properties, and surface modification method of poly(phthalazinone ether nitrile) having antibacterial properties
  • Poly(phthalazinone ether nitrile) having antibacterial properties, and surface modification method of poly(phthalazinone ether nitrile) having antibacterial properties
  • Poly(phthalazinone ether nitrile) having antibacterial properties, and surface modification method of poly(phthalazinone ether nitrile) having antibacterial properties

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Effect test

Embodiment 1

[0046] Embodiment 1 prepares modified polyarylether nitrile antibacterial material

[0047] In the first step, after the powder is hot-pressed, the PPENK board is washed with deionized water, ethanol, acetone and deionized water in sequence, and dried for later use. Put the PPENK plate into 4mol / L KOH solution, condense and reflux at 102°C and carry out magnetic stirring. The reaction time is 24 hours. After the reaction, put the product HPPENK sheet into 1mol / L hydrochloric acid solution. Minutes later, the material is washed and dried for later use;

[0048] In the second step, put HPPENK into 10mL of water, add 0.7668g of EDC and 0.1151g of NHS, and magnetically stir at room temperature for 2 hours to activate the carboxyl groups on the surface of the HPPENK sample. After the reaction, wash the sample three times with deionized water. Immerse the surface-activated HPPENK sheet into a PBS solution of ethylenediamine with a volume fraction of 1% (v / v), stir at room temperatu...

Embodiment 2

[0084] In the first step, after the PPENK powder is hot-pressed, the PPENK board is washed with deionized water, ethanol, acetone and deionized water in sequence, and dried for later use. Put PPENK tablets into 4mol / L KOH solution, reflux at 102°C and perform magnetic stirring. The reaction time is 24 hours. After the reaction, put the product HPPENK tablets into 1mol / L hydrochloric acid solution, over 5 Minutes later, the material is washed and dried for later use;

[0085] In the second step, put HPPENK into 10mL of water, add 0.7668g of EDC and 0.1151g of NHS, and magnetically stir at room temperature for 2 hours to activate the carboxyl groups on the surface of the HPPENK sample. After the reaction, wash the sample three times with deionized water.

[0086] The third step is to synthesize peptide 3

[0087] Accurately weigh 1.192g (4.38mmol) Boc-L-Lys-NCA and add it to a 50mL Shrek bottle, then add it to 15mL anhydrous DMF, and add 0.292g (0.146mmol) Boc-PEG after dissolv...

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Abstract

The invention belongs to the field of medical high molecular biomaterials, and particularly relates to a surface antibacterial and modified polyarylene ether nitrile antibacterial material containinga diazanaphthalene terphenyl structure, and a preparation method of the surface antibacterial and modified polyarylene ether nitrile antibacterial material containing a diazanaphthalene terphenyl structure. The material is prepared through performing chemical bonding of an antibacterial activity coating on the plane surface or a three-dimensional surface of poly(phthalazinone ether nitrile), wherein the antibacterial activity coating comprises a cation antibacterial polypeptide layer having antibacterial activity, and cation antibacterial polypeptide is fixed to the surface of the poly(phthalazinone ether nitrile) by a chemical bonding method. Under the premise that the mechanical properties of the polyarylene ether nitrile are not influenced, the biocompatibility of the polyarylene ethernitrile material can be improved, the polyarylene ether nitrile material has the antibacterial properties, the preparation method is simple, and the polyarylene ether nitrile material is suitable forbeing applied to the field of biologic medical materials.

Description

technical field [0001] The invention belongs to the field of medical macromolecular biomaterials, and in particular relates to a surface antibacterial modified polyarylether nitrile antibacterial material containing a phthalazinone biphenyl structure and a preparation method thereof. Background technique [0002] Antimicrobial materials are an effective way to solve bacterial infections caused by implanted devices. In the medical field, stomatology, orthopedics, dermatology, etc. require a large amount of antibacterial materials every year. Usually, an antibacterial material will destroy the cells while killing bacteria, so there is a big debate between biosafety and antibacterial activity. Therefore, obtaining a material that can inhibit the continuous proliferation of bacteria and has high biocompatibility has a good application prospect. [0003] Polynaphthalene polyarylether nitrile is a class of high-performance thermoplastic resins with excellent properties, and its ...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/18A61L27/54C08J7/12C08J7/16C08L71/10
CPCA61L27/34A61L27/18C08J7/16C08J7/123A61L27/54C08J2371/10A61L2300/252A61L2300/404A61L2400/18C08L89/00C08L71/00
Inventor 蹇锡高柳承德刘程王锦艳张守海翁志焕
Owner DALIAN UNIV OF TECH
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