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31 results about "Diazanaphthalene" patented technology

Diazanaphthalenes are a class of aromatic heterocyclic chemical compounds that have the formula C₈H₆N₂. They consist of a naphthalene double ring in which two of the carbon atoms have been replaced with nitrogen atoms. There are ten positional isomers, which differ by the locations of the nitrogen atoms.

Polar group or heterocyclic bridged phthalazinone structure polymer and preparation method thereof

The present invention provides a polymer with a polar group or a heterocyclic-bridged phthalazinone structure and a preparation method thereof, which relates to the technical field of synthesis of polymer materials. The polymer with a polar group or a heterocyclic-bridged phthalazinone structure mainly has more excellent heat resistance and good solubility by introducing a polar group or a heterocyclic-bridged phthalazinone structure. Its glass transition temperature can reach up to 405 °C and it can be dissolved in polar aprotic organic solvents such as N-methylpyrrolidone and 1,1,2,2-tetrachloroethane. In addition, the present invention can also regulate the heat resistance and solubility of such polymers by adjusting the structure and proportion of the structural unit with a polar group or a heterocyclic-bridged phthalazinone structure and other structural units, so that it can meet the needs of more different application scenarios. The present invention also provides a preparation method of the above polymer.
Owner:DALIAN UNIV OF TECH

Triarylamine compound and organic light-emitting device thereof

The invention provides a triarylamine compound and an organic light-emitting device thereof, and relates to the technical field of organic photoelectric materials. According to the compound, triarylamine serves as a center, fluorene derivative groups and aza-naphthalene groups are connected, the compound is applied to a light-emitting device to serve as a hole transport layer material, the light-emitting efficiency of the organic light-emitting device can be greatly improved, and the service life of the organic light-emitting device can be greatly prolonged; meanwhile, the triarylamine compound is used as a covering layer material to be applied to the organic light-emitting device, and the light-emitting efficiency of the device can be effectively improved. In addition, the compound has good physical and thermal stability, and the service life of the device can be prolonged. The compound can be widely applied to the fields of organic photovoltaic devices, organic light-emitting devices, organic solar cells, electronic paper, organic photoreceptors, organic thin film transistors, monochromatic or white lighting elements and the like.
Owner:CHANGCHUN HYPERIONS TECH CO LTD

Organic-inorganic hybrid adhesive, preparation method and application of organic-inorganic hybrid adhesive in aerogel heat insulation felt

The invention relates to the technical field of adhesives, and discloses an organic-inorganic hybrid adhesive, a preparation method and application of the organic-inorganic hybrid adhesive in aerogel heat insulation felts.The preparation method specifically comprises the steps that a mono-epoxy hepta (methoxyphenyl phthalazinone) POSS type connecting agent is synthesized and used for conducting modification treatment on silicon dioxide with the surface rich in hydroxyl, and then the modified silicon dioxide is obtained; the preparation method comprises the following steps: preparing nano silicon dioxide particles containing a methoxyphenyl phthalazinone POSS (Polyhedral Oligomeric Silsesquioxane) functional group; the preparation method comprises the following steps: compounding nano silicon dioxide particles containing methoxyphenyl phthalazinone POSS-based functional groups with an organic component phenolic resin on the basis of a pi-pi accumulation effect between benzene rings, so as to prepare the organic-inorganic hybrid adhesive; the glass fiber felt with excellent high temperature resistance is prepared by taking the organic-inorganic hybrid adhesive as an adhesive of chopped glass fibers, and can be used as a reinforcing material in the aerogel heat insulation felt, so that the prepared aerogel heat insulation felt shows excellent heat insulation performance.
Owner:NINGBO BOOER NEW MATERIAL CO LTD +1

Composite reverse osmosis membrane based on polyarylether sulphone-based membrane containing phthalazinone structure and preparation method of composite reverse osmosis membrane

The invention belongs to a separation membrane preparation technology, and discloses a composite reverse osmosis membrane based on a poly (aryl ether sulfone) base membrane containing a phthalazinone structure and a preparation method of the composite reverse osmosis membrane. The preparation method comprises the following steps: selecting a poly (aryl ether sulfone) containing the phthalazinone structure and a chloromethylated poly (aryl ether sulfone) blended ultrafiltration membrane as the base membrane; an ultrathin polyamide separation layer is compounded on the surface of an ultrafiltration base membrane by adopting an interfacial polymerization method, wherein the separation layer is prepared from polyamine and an acyl chloride monomer through interfacial polymerization. Polyamine in the water phase reacts with chloromethyl on the surface of the base membrane, so that chemical bond combination between the base membrane and the active layer is realized, and the stability of the reverse osmosis membrane is greatly improved. Besides, the phthalazinone structure-containing copolymer aryl ether sulfone molecular chain in the base membrane contains a full aromatic ring distorted non-coplanar phthalazinone structure, so that the composite reverse osmosis membrane has high glass transition temperature and excellent chemical stability, and the prepared composite reverse osmosis membrane has the characteristic of high temperature resistance. Powerful reference is provided for solving the problem of insufficient stability of the reverse osmosis membrane.
Owner:DALIAN UNIV OF TECH

Covalent organic polymer material based on polyquinone imidazole, preparation method of covalent organic polymer material and application of covalent organic polymer material in lithium ion battery negative electrode material

The invention belongs to the technical field of lithium ion batteries, and discloses a polyquinoneimidazole-based covalent organic polymer material, a preparation method thereof and an application of the polyquinoneimidazole-based covalent organic polymer material in a lithium ion battery negative electrode material. The preparation method comprises the following steps: carrying out a hydrothermal synthesis reaction on hexaaza-naphthalene carboxylic acid (HAT-6COOH) and tetraamino p-benzoquinone (TABQ) or 2, 3, 7, 8-tetraamino-1, 4, 6, 9-tetraquinone phenazine (TAPT) to prepare two kinds of polyquinoneimidazole organic polymer materials, and respectively recording the two kinds of polyquinoneimidazole organic polymer materials as HATTABQ and HATTAPT. The lithium ion battery based on the material disclosed by the invention shows relatively high specific capacity and relatively good cycle stability. Under the current density of 10 A / g, the HATTABQ electrode can reach the specific discharge capacity of 279.2 mAh / g in the first circle, the HATTABQ electrode can stably circulate for 20000 circles, and the capacity retention ratio is 78.4%. Under the current density of 5A / g, the HATTAPT electrode can reach the specific discharge capacity of 473.8 mAh / g in the first circle, the HATTAPT electrode can be stably circulated for 2000 circles, and the capacity retention ratio is 64.3%. The preparation method is simple in process and beneficial to large-scale industrial production, and has potential application value in lithium ion battery negative electrode materials.
Owner:LIAONING UNIVERSITY

2-phenyl-4-pinacol boryl-2, 1-boron aza-naphthalene, 2-phenyl-4-pyrimidinyl-2, 1-boron aza-naphthalene compound and preparation method of 2-phenyl-4-pinacol boryl-2, 1-boron aza-naphthalene compound

The invention discloses 2-phenyl-4-pinacol boryl-2, 1-boron aza-naphthalene, a 2-phenyl-4-pyrimidinyl-2, 1-boron aza-naphthalene compound and a preparation method of the 2-phenyl-4-pinacol boryl-2, 1-boron aza-naphthalene compound, and belongs to the technical field of organic synthetic chemistry. According to the preparation method, 2-phenyl-4-pinacolboryl-2, 1-boronaphthalene and bis (pinacol) diboron diboron ester are taken as raw materials, CuCl is taken as a catalyst, 4, 5-bis (diphenylphosphine)-9, 9-dimethyl xanthene is taken as a ligand, 2-adamantanone is taken as an additive, p-xylene is taken as a solvent, and the 2-phenyl-4-pinacolboryl-2, 1-boronaphthalene is efficiently obtained. The 2-phenyl-4-pyrimidinyl-2, 1-boron aza-naphthalene compound can be used as a key intermediate, the 2-phenyl-4-pyrimidinyl-2, 1-boron aza-naphthalene compound can be conveniently synthesized through efficient conversion of a C-B bond, and a new way is provided for functional modification of the boron-nitrogen heterocyclic compound.
Owner:JIANGSU OCEAN UNIV

Hexaaza-naphthyl polymer nanosheet / rod array composite material as well as preparation and application thereof

The invention relates to the technical field of preparation of new materials, in particular to a hexaaza-naphthyl polymer nanosheet / rod array composite material as well as preparation and application thereof. The preparation method comprises the following steps: dissolving a substrate material and a catalyst, and uniformly mixing to obtain a mixture; sequentially adding an amine monomer and a ketone monomer into the mixture, and uniformly mixing to obtain a reaction mixed solution; and finally, transferring the reaction mixed solution into a reaction kettle, and carrying out condensation polymerization to obtain the hexaaza-naphthyl polymer nanosheet / rod array composite material. The hexaaza-naphthyl polymer nanosheet / rod array composite material (with high specific surface area, rapid mass transfer path and clear and rich active sites) with a controllable structure is successfully prepared by a simple and efficient solvent-mediated interface anisotropic growth method; according to the method provided by the invention, the utilization rate of active sites can be increased, the conductivity is improved, and the method has wide application potential in the fields of energy, environment and cultural relic protection such as batteries and electro-catalysis.
Owner:SHANGHAI UNIV

Continuous fiber-reinforced thermoplastic resin-based prepreg, method of making, and composite

This invention discloses a continuous fiber reinforced thermoplastic resin-based prepreg, which is prepared by sequentially impregnating continuous fibers through a first impregnation and a second impregnation, followed by drying. The first impregnation solution contains a modifier, which includes an auxiliary thermoplastic resin and an auxiliary thermoplastic resin containing crosslinking groups. The second impregnation solution contains a bis(diazanaphthone)-structured thermoplastic resin, a soluble thermoplastic resin toughening agent, and a block copolymer. The auxiliary thermoplastic resin is a soluble amorphous thermoplastic resin with a glass transition temperature of 200°C or higher but lower than that of the bis(diazanaphthone)-structured thermoplastic resin. This invention employs a two-step impregnation method, using an auxiliary thermoplastic resin and an auxiliary thermoplastic resin containing crosslinking groups as modifiers for the first impregnation. The modifier's molecular chain flexibility is superior to that of the bis(diazanaphthone) resin, which facilitates preferential wetting of the continuous fiber surface and crosslinking anchoring.
Owner:DALIAN UNIV OF TECH

Cu3 (HTTT) 2MOF film and preparation method thereof

The invention discloses a Cu3 (HHTT) 2MOF film and a preparation method thereof, and belongs to the technical field of metal organic framework (MOF) material preparation, and the preparation method comprises the following steps: preparing a copper salt aqueous solution, preparing a hexahydroxy tetraazaphthalene organic solution, mixing the hexahydroxy tetraazaphthalene organic solution with a part of the copper salt aqueous solution to obtain a mixed solution, immersing a substrate in the residual copper salt aqueous solution, and then immersing the substrate in the copper salt aqueous solution to obtain the Cu3 (HHTT) 2MOF film. And then immersing in the mixed solution for standing reaction, taking out the substrate, and removing unreacted substances, water and the organic solvent to obtain the Cu3 (HHTT) 2MOF film on the substrate. The method has the advantages of mild reaction conditions, simplicity and convenience in operation, low cost, good repeatability and the like, uniform growth of the film is facilitated, and the prepared film has a good and complete crystal structure, is regular and uniform in structure, high in purity, good in crystallinity and stability and flat and smooth in surface, and is favorably applied to the fields of photoelectricity, sensing and the like.
Owner:JIHUA LAB

2-phenyl-4-pinanoylboronyl-2,1-borazaphenanthrene, 2-phenyl-4-pyrimidinyl-2,1-borazaphenanthrene compounds and methods for their preparation

The application discloses a 2-phenyl-4-pinacol boron-based-2,1-boronazanaphthalene, a 2-phenyl-4-pyrimidyl-2,1-boronazanaphthalene compound and a preparation method thereof, and belongs to the technical field of organic synthesis chemistry. The method is based on a copper-catalyzed selective dehydrogenation boronation reaction strategy, 2-phenyl-2,1-boronazanaphthalene and pinacol diboron ester are used as raw materials, CuCl is used as a catalyst, 4,5-bis(diphenylphosphino)-9,9-dimethyloxyanthracene is used as a ligand, 2-adamantanone is used as an additive, p-xylene is used as a solvent, and 2-phenyl-4-pinacol boron-based-2,1-boronazanaphthalene is efficiently obtained. The 2-phenyl-4-pinacol boron-based-2,1-boronazanaphthalene compound synthesized by the application can be used as a key intermediate, is efficiently converted through a C-B bond, and is convenient for synthesizing a 2-phenyl-4-pyrimidyl-2,1-boronazanaphthalene compound, thereby providing a new way for functional modification of boronazacyclic compounds.
Owner:JIANGSU OCEAN UNIV

Modified PETG material and application thereof in preparation of heat-resistant container

The invention discloses a modified PETG material and application thereof in preparation of a heat-resistant container, and the modified PETG material comprises the following raw materials by mass: 80-97% of PETG, 0.5-5% of a phthalazinone diphenol monomer, 0.5-5% of a styrene-maleic anhydride copolymer, 1-3% of a compatilizer, and 1-2% of nano-silica. Wherein acid anhydride in the styrene-maleic anhydride copolymer can be subjected to a ring-opening esterification reaction with phenolic hydroxyl groups of the phthalazinone diphenol monomer, and the formed cross-linked polymer can endow the modified PETG material with excellent high-temperature resistance (the thermal deformation temperature reaches 130 DEG C or above) and a rigid characteristic (the Young modulus reaches 3 GPa or above); and the nano silicon dioxide is beneficial to improving the good surface hardness (the surface hardness reaches 2H) of the modified PETG material.
Owner:SUNCHA TECH CO LTD

Treatment of Cushing's syndrome without significant impact on cardiac rhythm

Applicants disclose methods, uses, and compositions for treating patients suffering from Cushing Syndrome or Cushing Disease (collectively referred to as' CS ') without causing a significant QT interval extension (e.g., the difference of the QT interval after administration from the baseline QT interval by no more than about 10 milliseconds). The therapeutic amount of the heteroaryl ketone fused aza-naphthane compound may be from about 50 mg / day (mg / day) to up to about 500 mg / day, in embodiments, up to about 800 mg / day. The methods, uses, and compositions can shorten QT intervals, and can be used to treat QT prolongation in patients, including CS patients. The treatment may be a treatment administered orally to a fasting patient or an eating patient. The heteroaryl ketone fused aza-naphthane compounds can be administered with meals. The heteroaryl ketone fused aza-naphthane compound may be reracolan, which is (R)-(1-(4-fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl) sulfonyl)-4, 4a, 5, 6, 7, 8-hexahydro-1H-pyrazolo [3, 4-g] isoquinolin-4a-yl) (4-(trifluoromethyl) pyridin-2-yl) methanone having the following structure (I) # imgabs 0 #
Owner:CORCEPT THERAPEUTICS INC

A kind of impact-resistant elastic silicon PU material for plastic runway and its preparation method

The present invention relates to the field of polyurethane plastic technology, and discloses a kind of impact-resistant elastic plastic runway silicon PU material and preparation method thereof, the raw material of the PU material of the present invention includes component A, 100 parts of polyether polyols, 25 40 parts of fillers, 10 30 parts of organosilicon toughening agents; component B, 100 parts of polyether polyols, 68 75 parts of diphenylmethane 4,4 '-diisocyanates. There is good compatibility between the organosilicon toughening agent of the present invention and polyurethane, can be evenly dispersed in the polyurethane matrix, containing flexible siloxane structure, plays a good toughening effect on polyurethane, significantly improves the impact strength, flexural strength, wear resistance of PU materials. And the organosilicon toughening agent contains a diazinone structure with high temperature resistance, is added to polyurethane, and can improve the thermal decomposition temperature and heat resistance of the material.
Owner:GUANGDONG DECHAO SPORTS FACILITIES CO LTD

Treatment of amyotrophic lateral sclerosis using dangencan

Applicants disclose methods and compositions for treating a patient suffering from amyotrophic lateral sclerosis (ALS), comprising administering a heteroaryl ketone fused aza-naphthane compound. In embodiments, the heteroaryl ketone fused aza-naphthane compound is Dargencolan: (R)-(1-(4-fluorophenyl)-6-((4-(trifluoromethyl) phenyl) sulfonyl)-4, 4a, 5, 6, 7, 8-hexahydro-1-H-pyrazolo [3, 4-g] isoquinolin-4a-yl) (pyridin-2-yl) methanone, the chemical structure of which is shown as follows: # imgabs 0 # suitable doses include the administration of 150 and 300 milligrams of Dargencolan per day. Suitable doses include daily administration of Datangencan with food, or with water, or with food and water. Daily administration of dazulan can effectively increase exposure of dazulan and can increase exposure of dazulan up to about 2 times when sustained for seven or more days. Administration of such heteroaryl ketone fused aza-naphthane compounds includes oral administration, enteral administration, or other modes of administration. A pharmaceutical composition comprising daricor is useful for the treatment of a patient suffering from ALS. Suitable pharmaceutical compositions comprising daricor include, for example, pharmaceutical compositions for oral administration and pharmaceutical compositions for enteral administration.
Owner:CORCEPT THERAPEUTICS INC

Antibacterial polyaryletherketone and preparation method thereof

PendingCN121718012APolymer scienceBenzophenone
The invention discloses antibacterial polyaryletherketone and a preparation method thereof, and belongs to the technical field of polymer synthesis. The preparation method comprises the following steps: by taking phthalazinone (DHPZ), brominated phthalazinone (DHPZ-Br) and 4, 4 '-difluorobenzophenone (DFK) as raw materials, carrying out ternary polymerization reaction in the presence of alkali to generate PPEK-B; and then reacting with OIT in the presence of a catalyst and alkali to generate PPEK-OIT. The proportion of the antibacterial units can be adjusted at will, and the composite material can be independently used as an antibacterial material; and a high polymer material with all OIT antibacterial units can also be generated, and is added into other high polymer materials as an antibacterial agent.
Owner:大连中科聚合新材料科技有限公司

Corrosion inhibitor compositions for reducing corrosion, and related methods of operating a wellbore

A method of removing a calcareous material from sand while processing the sand includes mining sand at a location proximate a wellbore extending into an earth formation, and contacting the sand with an aqueous treatment fluid to remove calcareous materials from the sand and form treated hydraulic fracturing sand, the aqueous treatment fluid including a corrosion inhibitor composition. The corrosion inhibitor composition includes an alkenylphenone, and a substituted 1-azanapthalene. Related methods of inhibiting corrosion and of sand processing equipment during processing of hydraulic fracturing sand and removing calcareous materials from sand are also disclosed.
Owner:SCHLUMBERGER TECH CORP +3

Crystal form of fused tricyclic derivative and preparation method

The present disclosure relates to a crystal form of a fused tricyclic derivative and a preparation method, and specifically relates to a crystal form of a compound (3S,4R)-4-((5-chloro-4-((S)-8-fluoro-2-(2-hydroxypropane-2-yl)-3-methyl-3,4-dihydro-5-oxa-1,2a-diazacenaphthylene-6-yl)pyrimidine-2-yl)amino)tetrahydro-2H-pyran-3-ol, a pharmaceutically acceptable salt thereof, and a corresponding preparation method.
Owner:JIANGSU HENGRUI MEDICINE CO LTD

Wave-transparent resin for aircraft equipment compartment and preparation method of wave-transparent resin

The invention relates to the technical field of wave-transparent materials, in particular to wave-transparent resin for an aircraft equipment compartment and a preparation method of the wave-transparent resin. The method comprises the following steps: reacting 5-bromine-2-fluorine-trifluorotoluene with chirality-1, 1 '-co-2-naphthol under the protection of nitrogen to obtain a chiral monomer, polymerizing the chiral monomer with biphenyl phthalazinone through an initiator to obtain a prepolymer, and finally terminating with 4-nitrophthalonitrile to obtain the target resin. According to the method, regular accumulation of molecules is destroyed by mixing 1, 1 '-bi-2-naphthol with different configurations, and the low polarity of-CF3 and a rigid framework of biphenyl phthalazinone are combined, so that the dielectric property and the thermal stability of the resin are cooperatively regulated and controlled. The obtained wave-transparent resin is low in dielectric constant and loss, high in thermal decomposition temperature and glass transition temperature, excellent in mechanical property and high-temperature retention rate, low in softening point and good in solubility, can be easily compounded and molded with quartz fiber cloth, is suitable for preparation of wave-transparent composite materials for aircraft equipment cabins, and meets the requirements of broadband high-temperature service.
Owner:JIANGSU KELUWEI NEW MATERIAL TECH CO LTD

Poly (phthalazinone) copolyether sulfone membrane, preparation method and filter

The invention relates to the technical field of membrane separation, in particular to a phthalazinone copolyether sulfone membrane which is formed by copolymerization of phthalazinone diphenol, dichlorodiphenyl sulfone and biphenol, the molecular structure of the phthalazinone copolyether sulfone membrane comprises sulfonyl and phthalazinone structural units, and the molar percentage of the phthalazinone diphenol is 20-40%. Along with the increase of the content of the phthalazinone structure in the phthalazinone copolyethersulfone, finger-shaped pores in the hollow fiber membrane disappear and become spongy pores, the membrane structure becomes compact, the surface of the hollow fiber membrane becomes a loose and porous structure, the hydrophilicity of the hollow fiber membrane is improved, the water contact angle of the hollow fiber membrane is reduced from 71.5 degrees to 58.5 degrees, and the water contact angle of the hollow fiber membrane is reduced from 71.5 degrees to 58.5 degrees. The porosity of the hollow fiber membrane is reduced, the water flux is firstly increased and then reduced, and the breaking strength of the membrane is improved.
Owner:ZHEJIANG THINK ENERGY TECH

Continuous fiber reinforced bis-anthracene thermoplastic resin matrix prepreg, preparation method and composite material

PendingCN122445190AThermoplasticPolymer science
The application discloses a continuous fiber reinforced bisnaphtholone structure thermoplastic resin based prepreg, and raw material compositions for preparing the prepreg include, in mass fraction, continuous fibers, bisnaphtholone structure thermoplastic resin, semi-crystalline thermoplastic resin and block copolymer; the molecular chain of the block copolymer includes bisnaphtholone structure thermoplastic resin repeating units and semi-crystalline thermoplastic resin repeating units, or naphthalene-coupled biphenyl structure polyarylene ether repeating units and semi-crystalline thermoplastic resin repeating units. The application adds semi-crystalline thermoplastic resin, and simultaneously introduces block copolymer containing bisnaphtholone repeating units or naphthalene-coupled biphenyl structure polyarylene ether repeating units and semi-crystalline thermoplastic resin repeating units in the molecular chain, so that the porosity of the prepreg is low, and the mechanical properties of the composite material prepared from the prepreg are excellent and the interlayer combination is good.
Owner:DALIAN UNIV OF TECH

Hexaazaphthalene-based multi-electron aqueous flow battery energy storage material

The invention provides an energy storage material based on a hexaaza-naphthalene multi-electron aqueous flow battery, and particularly provides a hexaaza-naphthalene multi-electron compound which can be used as the energy storage material of the aqueous flow battery. The preparation method of the compound is simple, and the prepared battery energy storage material has relatively good cycling stability and energy efficiency and is suitable for being used as an energy storage material of an aqueous flow battery.
Owner:WESTLAKE UNIV

Corrosion inhibitor compositions for reducing corrosion, and related methods of operating a wellbore

A method of reducing corrosion within a wellbore includes placing a wireline including a perforating gun in a wellbore, the wellbore extending through an earth formation and including a casing extending through the earth formation, the wireline including zinc, discharging the perforating gun to form perforations through the casing and in the earth formation surrounding the casing proximate the at least one perforating gun, flowing a fracturing fluid including one or more proppants through the perforations and into the earth formation to open fractures in the earth formation with the one or more proppants, introducing a flushing fluid into the wellbore to displace the fracturing fluid, and flowing a corrosion inhibitor composition into the wellbore and through the perforations with at least one of the fracturing fluid and the flushing fluid. The corrosion inhibitor includes an alkenylphenone, and a substituted 1-azanapthalene.
Owner:SCHLUMBERGER TECH CORP

Application of a metal phenolic gelatin-coated modified polyarylether bone graft in bone repair under oxidative stress

The present invention provides a polyarylether bone implant material modified with a metal phenolic gelatin coating for use in bone repair under oxidative stress. The polyarylether bone implant material modified with a metal phenolic gelatin coating comprises a polyarylether base material containing a diazinone biphenyl structure and a metal phenolic gelatin coating, the two being integrated into one by imitating the physical adhesion of mussels; the metal phenolic gelatin coating precursor solution comprises a multifunctional phenolic monomer containing diazinone biphenyl, FeCl3, gelatin (Gel), and a solvent. The preparation process of the present invention is relatively simple, and the resulting hydrogel-coated polyarylether material modified with a diazinone biphenyl does not require the addition of an additional anti-inflammatory component, and has excellent ROS scavenging efficiency, antioxidant and anti-inflammatory activity, while also having an osteogenesis-promoting effect, providing a good environment for the osteogenic differentiation of stem cells, and helping the implant material to better promote bone regeneration and bone fusion in vivo. The invention has broad application prospects in the field of polymer bone implant materials.
Owner:DALIAN UNIV OF TECH

Compounds or pharmaceutically acceptable salts thereof and crystalline forms thereof

The present disclosure provides (2R,4aR,7R)-3-acryloyl-12-chloro-10-fluoro-11-((S)-2-fluoro-6-hydroxyphenyl)-2-methyl-7-((S)-1-methylpyrrolidin-2-yl)-2,3,4,4a,6,7-hexahydro-8-oxa-3,5a,9,13c-tetraazanaphtho[3,2,1-de]anthracen-5(1H)-one (hereinafter referred to as "Compound I") or a pharmaceutically acceptable salt thereof and a crystal form thereof. The present disclosure also provides a pharmaceutical composition comprising at least one of Compound I or a pharmaceutically acceptable salt thereof and a crystal form thereof, and a method for preparing the crystal form. The present disclosure further provides the use of Compound I or a pharmaceutically acceptable salt thereof and a crystal form thereof or a pharmaceutical composition comprising at least one of Compound I or a pharmaceutically acceptable salt thereof and a crystal form thereof in the prevention and / or treatment of a disease, particularly a disease mediated by KRAS G12C mutation. The crystal form of Compound I or a pharmaceutically acceptable salt thereof of the present disclosure is excellent in hygroscopicity, solubility and stability.
Owner:SHANGHAI ALLIST PHARM CO LTD

Halogen-free flame-retardant polyurethane elastomer and preparation process therefor

PCT designated stageWO2025227505A1Phosphoric Acid EstersPolymer science
Disclosed are a halogen-free flame-retardant polyurethane elastomer and a preparation process therefor. Phenyl dichlorophosphate and 4-(4-hydroxyphenyl)-2,3-diaza(4-nitrophenyl)naphthalen-1-one undergo a phosphate esterification reaction, followed by reduction with a Pd / C catalyst to yield a novel phosphate-bis-diazanaphthalone chain extender. Introducing a highly thermally stable bis-diazanaphthalone rigid fused-ring structure into a polyurethane molecular chain significantly increases the thermal decomposition temperature of the polyurethane elastomer; moreover, the phosphate-bis-diazanaphthalone chain extender contains a phosphate-based flame-retardant structure that forms a nitrogen-phosphorus halogen-free flame retardant with a diazanaphthalone nitrogen-containing heterocycle, achieving a condensed-phase flame-retardant effect; thus, the total heat release and the peak heat release rate of the polyurethane elastomer are reduced, and excellent flame-retardant performance is achieved.
Owner:SHANGHAI JIELI NEW MATERIALS TECHNOLOGY CO LTD

Chloromethylated polyarylether sulfone and phthalazinone structure-containing polyarylether sulfone blended ultrafiltration membrane and preparation method thereof

The invention belongs to a separation membrane preparation technology, and discloses a chloromethylated polyarylether sulfone and phthalazinone structure-containing polyarylether sulfone blended ultrafiltration membrane and a preparation method of the chloromethylated polyarylether sulfone and phthalazinone structure-containing polyarylether sulfone blended ultrafiltration membrane. The preparation method comprises the following steps: selecting poly (aryl ether sulfone) containing a phthalazinone structure and chloromethylated poly (aryl ether sulfone) as membrane materials, adding a solvent and an additive to prepare a membrane casting solution, and preparing the blended ultrafiltration membrane by a phase inversion method. As the molecular chain of the poly (aryl ether sulfone) containing the phthalazinone structure contains a whole aromatic ring distorted non-coplanar phthalazinone structure, the poly (aryl ether sulfone) containing the phthalazinone structure has higher glass-transition temperature and excellent chemical stability, and the novel ultrafiltration membrane prepared from the poly (aryl ether sulfone) containing the phthalazinone structure has excellent high temperature resistance, acid and alkali resistance and oxidation resistance, and can be used for preparing the ultrafiltration membrane. Powerful reference is provided for solving the problem of insufficient temperature resistance of the ultrafiltration membrane, and the application range of the ultrafiltration membrane is expanded.
Owner:DALIAN UNIV OF TECH