Improved protein A immunosorbent column

Abstract

The invention discloses an improved protein A immunosorbent column. The immunosorbent column comprises a connecting unit and protein A immunosorbent column bodies, wherein the connecting unit comprises a liquid inlet pipe and a liquid outlet pipe, the liquid inlet pipe and the liquid outlet pipe are horizontally arranged, and the liquid inlet pipe is positioned above the liquid outlet pipe; and two groups of protein A immunosorbent column bodies are arranged, the two groups of protein A immunosorbent column bodies are arranged in parallel, and the upper end of each group of protein A immunosorbent column body is communicated with the bottom of the liquid inlet pipe through a first connecting pipe. The immunosorbent column can realize a scheme of providing uninterrupted treatment for a patient, can greatly shorten the treatment time which originally needs to take 5 hours at one time to 2.5 hours, not only saves a large amount of time for the patient and medical personnel, but also can eliminate the hidden danger of sudden adverse reaction of the patient caused by long-time treatment, can avoid the problem that a filter element is easy to be installed in error during processing and production, and simultaneously effectively improves the production efficiency.

Description

technical field [0001] The invention relates to the technical field of medical equipment, more specifically, it relates to an improved protein A immunoadsorption column. Background technique [0002] Plasma adsorption is that after the blood is drawn out, it first enters the plasma separator to separate the formed components of the blood (blood cells, platelets) from the plasma, and the formed components are returned to the patient, and then the plasma enters the adsorber (adsorption column) to absorb and remove some specific substances. After absorption, the plasma is returned to the patient. Plasma adsorption is mainly divided into two categories according to the characteristics of the adsorbent. One is molecular sieve adsorption, which uses the principle of molecular sieve to non-specifically adsorb substances corresponding to the charge and molecular size through the charge and pores carried by the adsorbent, such as Activated carbon, resin, carbonized resin and cationi...

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Problems solved by technology

[0003] The protein A immunoadsorption column in the prior art can only treat for 15 minutes in one cycle, and then needs to be eluted and regenerated for 15 minutes. A treatment generally requires 10 cycles and takes 5 hours, which leads to a long treatment time and a waste of time A lot of time, and there is also the hidden danger of sudden adverse reactions caused by long-term treatment; in addition, the existing Chinese patent application number CN201220127328.6 discloses a protein A immunoadsorption column, which includes a column, a gasket, Filter membrane, sealing ring, end cap, in which the filter membrane is welded on the gasket and socketed together with the sealing ring. The sealing ring can cooperate with the depression on the cylinder, and the end cap has internal thread, which cooperates with the external thread on the cylinder. , after tightening, the sealing ring, gasket and filter membrane can be compressed

Although the Chinese patent with the application number CN201220127328.6 has the advantages of good sealing, no dead space when the liquid flows through, and the filter membrane is not easy to be damaged, it is suitable for the production of plasma adsorption or plasma perfusion products, but it welds the filter membrane on the pad On the sheet, and at the liquid inlet end, the filter membrane is outside and the gasket is inside; at the liquid outlet end, the filter membrane is inside and the gasket is outside, which can prevent the filter membrane from being damaged by force along the direction of water flow, so as to ensure that the medium It will not leak, which leads to the problem that it is easy to install the wrong installation position of the filter membrane and the gasket during processing and production, and it also affects the production efficiency. Therefore, an improved protein A immunoadsorption column is proposed

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