The invention discloses mesoporous modified polyurethane resin for an automotive interior trim and a preparation method of the mesoporous modified polyurethane resin. The mesoporous modified polyurethane resin comprises the following raw material components: a precursor, a silane coupling agent, phosphorous acid, 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, a novel flame retardant, diphenylmethane diisocyanate, ethylene glycol, 1,4-butanediol, polyester dihydric alcohol, toluene, N, N-dimethylformamide, a catalyst, methanol and ammonium bicarbonate, wherein the precursor is prepared from ammonium silicate, triethylene tetramine and a zinc ammonia complex through reaction, wherein the zinc ammonia complex is prepared from zinc sulfate, ammonia gas and reaction through reaction, and the novel flame retardant is prepared from oxalic acid, water and urea. According to the mesoporous material prepared by virtue of the preparation method, the mechanical strength of a polyurethane product can be increased, the surface functionality and the hydrophily of polyurethane can be improved, and meanwhile, polyurethane is endowed with excellent properties such as transparency, mold resistance, flame retardance, peel strength, thermal insulation, sound absorption and the like.