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A method for preparing spherical vaterite particles by microwave biomineralization

A technology of biomineralization and vaterite, which is applied in the field of bionic materials, can solve the problems of long vaterite time and environmental pollution, and achieve the effects of good controllability, environmental friendliness and reduced reaction time

Active Publication Date: 2021-12-10
LIAONING TECHNICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the existing literature or patents, most of the vaterite particles are prepared by adding additives such as surfactants. These additives either pollute the environment, or the vaterite obtained by biomineralization takes a long time
At present, the speed of biomimetic synthesis is accelerated by microwave heating, and the process of biomineralization is promoted. The method of preparing spherical vaterite particles by microwave biomineralization has not been reported yet.

Method used

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  • A method for preparing spherical vaterite particles by microwave biomineralization
  • A method for preparing spherical vaterite particles by microwave biomineralization
  • A method for preparing spherical vaterite particles by microwave biomineralization

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Embodiment 1

[0032] A method utilizing microwave biomineralization to prepare spherical vaterite particles, comprising the following steps:

[0033] Step 1: Prepare a mixed solution of 0.6mol / L urea and 1mol / L calcium acetate monohydrate;

[0034] Step 2: Prepare urease solution, add urease into distilled water; the concentration range is 0.025g / L, and the urease activity is 148u / mg;

[0035] Step 3: adding the urease solution to the mixed solution in step 1 to obtain a reaction solution, wherein the volume ratio of the urease solution to the mixed solution is 1:9;

[0036] Step 4: Pour the reaction solution into a double-necked round-bottomed flask, put the stirring magnet into the double-necked round-bottomed flask, put the double-necked round-bottomed flask into a microwave reactor, and connect the side end of the double-necked round-bottomed flask to a thermoelectric Coupled, the top interface is connected to the condenser pipe, and the cooling water is passed into the condenser pipe ...

Embodiment 2

[0044] A method utilizing microwave biomineralization to prepare spherical vaterite particles, comprising the following steps:

[0045] Step 1: Prepare a mixed solution of 0.6mol / L urea and 1mol / L calcium acetate monohydrate;

[0046] Step 2: Prepare urease solution, add urease into distilled water; the concentration range is 0.0675g / L, and the urease activity is 148u / mg;

[0047] Step 3: adding the urease solution to the mixed solution in step 1 to obtain a reaction solution, wherein the volume ratio of the urease solution to the mixed solution is 1:9;

[0048] Step 4: Pour the reaction solution into a double-necked round-bottomed flask, put the stirring magnet into the double-necked round-bottomed flask, put the double-necked round-bottomed flask into a microwave reactor, and connect the side end of the double-necked round-bottomed flask to a thermoelectric Coupled, the top interface is connected to the condenser pipe, and the cooling water is passed into the condenser pipe f...

Embodiment 3

[0056] A method utilizing microwave biomineralization to prepare spherical vaterite particles, comprising the following steps:

[0057] Step 1: Prepare a mixed solution of 0.6mol / L urea and 1mol / L calcium acetate monohydrate;

[0058] Step 2: Prepare urease solution, add urease into distilled water; the concentration range is 0.1g / L, and the urease activity is 148u / mg;

[0059] Step 3: adding the urease solution to the mixed solution in step 1 to obtain a reaction solution, wherein the volume ratio of the urease solution to the mixed solution is 1:9;

[0060] Step 4: Pour the reaction solution into a double-necked round-bottomed flask, put the stirring magnet into the double-necked round-bottomed flask, put the double-necked round-bottomed flask into a microwave reactor, and connect the side end of the double-necked round-bottomed flask to a thermoelectric Coupled, the top interface is connected to the condenser pipe, and the cooling water is passed into the condenser pipe fo...

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Abstract

The invention discloses a method for preparing spherical vaterite particles by utilizing microwave biomineralization, comprising the steps of: configuring a mixed solution of urea and calcium acetate monohydrate; configuring a urease solution, adding the urease solution to the mixed solution to obtain a reaction solution; Pour the reaction solution into a double-necked round-bottom flask, put the stirring magnet into the double-necked round-bottom flask, and put the double-necked round-bottom flask into the microwave reactor; select the microwave frequency, set the microwave reaction temperature, time, and stirring magnet Rotation rate; Ultrasonic the reaction product to obtain a suspension, pour the suspension into a centrifuge tube for centrifugation, and pour off the supernatant; Add distilled water for ultrasonic cleaning to remove unreacted substances; Dry the collected white particle precipitate, that is have to. The invention speeds up the formation speed of the spherical vaterite particles in the biomineralization process by applying microwaves, and can controllably adjust the size of the vaterite particles by changing the concentration of urease. The reaction process is fast, and the reagents used are non-polluting and environmentally friendly.

Description

technical field [0001] The invention belongs to the technical field of bionic materials, and in particular relates to a method for preparing spherical vaterite particles by utilizing microwave biomineralization. Background technique [0002] Vaterite is a kind of calcium carbonate with various shapes, such as spherical, cauliflower, hexagonal flakes and so on. Among them, spherical vaterite is a structure composed of very small primary particles, and the size can be adjusted so that the scale of spherical vaterite particles reaches the order of microns. Micron spherical vaterite particles have the characteristics of large specific surface area, high solubility and dispersibility, and have broad application prospects in the fields of medicine, coatings, inks, and papermaking. As a drug carrier, vaterite particles can load salicylic acid and other drugs, improve the sustained release performance of drugs, and better exert the curative effect of drugs. Adding vaterite particl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01F11/18
CPCC01F11/18C01P2002/72C01P2004/03C01P2004/32C01P2004/61
Inventor 杨建林张岩李喜林王来贵宋诗雨白世震
Owner LIAONING TECHNICAL UNIVERSITY