Unlock instant, AI-driven research and patent intelligence for your innovation.

Giant salamander active peptide and hyaluronic acid composition that effectively promotes fibroblast proliferation

A technology of fibroblasts and active peptides, applied in the field of skin care products

Active Publication Date: 2022-05-20
深圳润朗医药科技有限公司
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, so far, there is no report on the combination of giant salamander active peptide solution and hyaluronic acid to improve the effect of promoting fibroblast proliferation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Giant salamander active peptide and hyaluronic acid composition that effectively promotes fibroblast proliferation
  • Giant salamander active peptide and hyaluronic acid composition that effectively promotes fibroblast proliferation
  • Giant salamander active peptide and hyaluronic acid composition that effectively promotes fibroblast proliferation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The giant salamander active peptide and hyaluronic acid composition for effectively promoting the proliferation of fibroblasts of the present invention is prepared by mixing a giant salamander active peptide solution with a mass volume concentration of 8% and a pH of 6 and hyaluronic acid in a mass ratio of 5:1. The molecular weight of the giant salamander active peptide is 5:1. Less than 2000Da, the molar percentages of lysine and arginine are 7.2% and 9.7%, respectively, and the molecular weight of hyaluronic acid is 80kDa. The giant salamander active peptide solution with a mass-volume concentration of 8% and a pH of 6 is prepared by adding water to the giant salamander active peptide solution with a mass-volume% (w / v) mass of salamander active peptide solution, and the pH is adjusted to 6 with dilute hydrochloric acid.

[0026] The giant salamander active peptide is prepared according to the following steps:

[0027] a. Homogenize giant salamander meat, add 2 times ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention discloses a giant salamander active peptide and hyaluronic acid composition that can effectively promote the proliferation of fibroblast cells. The mass ratio of a giant salamander active peptide solution with a mass volume concentration of 1-10% and a pH of 5-7 to hyaluronic acid is 1-8:1. The molecular weight of the giant salamander active peptide is less than 2000Da, the molar percentages of lysine and arginine are 7.2% and 9.7% respectively, and the molecular weight of the hyaluronic acid is 42.5-145kDa. Giant salamander active peptides can be naturally cross-linked with hyaluronic acid rich in multiple hydroxyl groups through hydrogen bonds. Using the natural affinity between hyaluronic acid and human skin cells, it can effectively improve the proliferation of skin fibroblasts. It is widely used in the fields of medicine and cosmetics. Broad application prospects.

Description

technical field [0001] The invention belongs to the technical field of skin care products, in particular to a giant salamander active peptide and hyaluronic acid composition for effectively promoting the proliferation of fibroblasts. Background technique [0002] Bioactive peptides are mainly the products of enzymatic hydrolysis of proteins by enzymes. Different enzymes and enzymatic hydrolysis methods are used to hydrolyze proteins from the same source, and the enzymatic hydrolysis products will have different biological activities due to different structures. Fu Jing et al. studied the peptide yields of five kinds of enzymes, including alkaline protease, neutral protease, Flavourzyme, Protamex and Alcalase, for 5 hours of enzymatic hydrolysis of giant salamander meat. The optimal conditions for the enzymatic hydrolysis of giant salamander meat are: solid-liquid ratio of 1:35, temperature of 60 °C and enzymatic hydrolysis time of 7 h (Fu Jing, Chen Dejing, Cao Mina. Researc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/73A61K8/64A61Q19/00A61K38/01A61K31/728A61P17/00C12P21/06C07K1/34C07K1/16C07K1/14
CPCA61K8/735A61K8/64A61Q19/00A61K38/012A61K31/728A61P17/00C12P21/06C07K1/34C07K1/16C07K1/14A61K2300/00
Inventor 李伟佟长青
Owner 深圳润朗医药科技有限公司