Composition capable of repairing skin barriers and preparation method and application of composition

A composition and compound technology, applied in the field of biomedicine and personal care products, can solve the problems of excessive water loss, dry skin, damaged skin barrier, etc., achieve excellent appearance and moisture retention, quickly repair the skin barrier, and resist the outside world stimulating effect

Pending Publication Date: 2020-01-03
XIANGYA HOSPITAL CENT SOUTH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the improper use of environment, diet and skin care products, it is easy to cause damage to the skin barrier, especially easy to cause excessive w...

Method used

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  • Composition capable of repairing skin barriers and preparation method and application of composition
  • Composition capable of repairing skin barriers and preparation method and application of composition
  • Composition capable of repairing skin barriers and preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Table 1 Group 1~9 and CK control group side (unit: wt%)

[0071]

[0072]

[0073] The preparation method is:

[0074] Step 1: Prepare the oil phase mixture: mix ceramide, cholesterol, hydrogenated lecithin and octyldodecanol together, heat in a water bath to a temperature of 85°C, and stir slowly at a stirring speed of 100rpm to ensure that the oil phase is mixed uniform. stand-by.

[0075] Step 2: Preparation of the aqueous phase mixture: The calcium ionic compound, betaine, polyol and water are mixed together. Heating in a water bath to a temperature of 85° C., stirring slowly at a stirring speed of 100 rpm to ensure that the water phase is dissolved and transparent. stand-by.

[0076] The third step: the oil phase mixture is added to the water phase, and prepared by feeding through a high-speed and high-pressure homogenizer (the parameters are 1300 bar pressure and 3 cycles of homogenization). Finally, a translucent or milky white body is prepared.

[00...

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PUM

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Abstract

The invention relates to the technical field of biological pharmaceuticals and personal nursing, in particular to a composition capable of repairing skin barriers and a preparation method and application of the composition. The composition provided by the invention consists of a calcium ion compound, ceramide, cholesterol, hydrogenated lecithin and betaine. The composition disclosed by the invention is used for repairing the skin barriers, and all the components achieve significant synergistic reactions, so that the synthesis of intercellular lipid of skin can be effectively supplemented and promoted, damaged skin and muscle can also be repaired, and skin and muscle barriers can be reconstructed. Besides, the invention provides an effective preparation method of the composition capable ofrepairing skin barriers. The composition has clear relieving and treating effects on sub-health skin of sensitive skin, atopic dermatitis and the like.

Description

technical field [0001] The invention relates to the technical fields of biomedicine and personal care products, in particular to a composition for repairing skin barrier, its preparation method and application. Background technique [0002] The skin barrier in a narrow sense refers to the "brick wall structure" of the sebum membrane and the stratum corneum. The "brick wall structure" of the stratum corneum is a composite structure composed of proteins and lipids, which not only effectively prevents the loss of water from the inside but also provides It forms a protective barrier against external stimuli and pathogens, protects the skin from external substances, and plays a great role in maintaining skin health. A healthy epidermal barrier mainly consists of: good keratinocytes, an intact lipid layer and a well-defined bilayer structure of lipid matrix. However, due to improper use of environment, diet and skin care products, it is easy to cause damage to the skin barrier, e...

Claims

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Application Information

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IPC IPC(8): A61K8/9728A61K8/20A61K8/34A61K8/365A61K8/44A61K8/49A61K8/55A61K8/63A61K8/68A61Q19/00
CPCA61K8/68A61K8/63A61K8/553A61K8/44A61K8/345A61K8/20A61K8/4913A61K8/9728A61K8/365A61Q19/00A61K2800/85
Inventor 李吉谢红付王乾
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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