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A kind of hypoglycemic compound for promoting islet regeneration and preparation method and use thereof

A complex and hypoglycemic technology, applied in application, drug combination, pharmaceutical formula, etc., can solve problems such as adverse reactions, inability to take orally, toxic effects, etc., and achieve the effect of high safety and convenient administration

Active Publication Date: 2022-07-15
博生众康(厦门)医药生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparations or schemes provided in these patent application documents have the following problems: 1) It is inconvenient to use, such as polypeptide or protein preparations, which cannot be taken orally, and long-term injections are required if they are applied in clinical practice; 2) The curative effect is not clear; 3) Whether it is Polypeptides or traditional Chinese medicine compound preparations are all drugs, and long-term use will inevitably cause adverse reactions to the body, and even toxic effects

Method used

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  • A kind of hypoglycemic compound for promoting islet regeneration and preparation method and use thereof
  • A kind of hypoglycemic compound for promoting islet regeneration and preparation method and use thereof
  • A kind of hypoglycemic compound for promoting islet regeneration and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of hypoglycemic complex for promoting islet regeneration and verification of its effect

[0027] Raw materials: see Table 1.

[0028] Preparation method: α-lipoic acid and L-taurine are food-grade commercial products. Crush cinnamon, wolfberry, bitter gourd, fenugreek, gymnasium, chickpea, ginger, hawthorn, and pass through a 60-100 mesh sieve. Add edible ethanol with a concentration of 10-95% to each component, the solid-liquid weight ratio is 1:10-25, the ultrasonic power is 400W, the work / interval is 15s / 3s, the ultrasonic time is 10-30min, and the ultrasonic frequency is 1- 3 times, rotary-evaporated under reduced pressure at 60°C to obtain solid powder. The solid powders are mixed in proportion. Can be made into capsules for easy administration.

[0029] Table 1 Example 1-5 each raw material consumption table

[0030]

[0031] Effect verification test:

[0032] Example 1 was verified by using a mouse type 2 diabetes model induced by ...

Embodiment 2

[0076] Example 2: Preparation of hypoglycemic complex for promoting islet regeneration

[0077] Raw materials: see Table 1.

[0078] Preparation method: same as Example 1.

[0079] The effect is the same as that of Example 1.

Embodiment 3

[0080] Example 3: Preparation of hypoglycemic complex for promoting islet regeneration

[0081] Raw materials: see Table 1.

[0082] Preparation method: same as Example 1.

[0083] The effect is the same as that of Example 1.

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Abstract

The invention discloses a hypoglycemic compound for promoting islet regeneration and a preparation method and application thereof. Includes chickpea or chickpea extract, alpha-lipoic acid, L-taurine, cinnamon or cinnamon extract, wolfberry or wolfberry extract, balsam pear or balsam pear extract, fenugreek or fenugreek ethanolic extract , Gymnema or Gymnema sylvestre extract, ginger or curcumin, hawthorn or hawthorn extract. The islet regeneration-promoting hypoglycemic compound adopts safe and effective medicinal and edible food materials, which can protect the islet function of diabetic patients, slow down the reduction or destruction of its function, and promote the islet regeneration to achieve the purpose of lowering blood sugar.

Description

technical field [0001] The invention relates to the field of diabetes formulations, in particular to a hypoglycemic compound for promoting islet regeneration and a preparation method and application thereof. Background technique [0002] Diabetes mellitus (DM) is a comprehensive metabolic disorder characterized by elevated blood sugar caused by genetic factors, environmental factors and their interactions, resulting from defects in insulin secretion and / or action. disease. According to the statistics of the Diabetes Federation (IDF) in 2017, the number of adults with diabetes over the age of 18 in the world is increasing year by year, reaching 424 million in 2017. Also according to the report, the number of diabetic patients in my country has reached 114 million. Diabetes and its complications bring pain to patients and a serious economic burden to their families. [0003] According to different pathogenesis, diabetes can be divided into type 1, type 2, other types of dia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K36/815A61P3/10A61P5/50A23L33/10A23L33/105A23L33/175A61K31/12A61K31/185A61K31/385
CPCA61K36/48A61K31/385A61K31/185A61K36/54A61K36/815A61K36/42A61K36/27A61K36/9068A61K31/12A61K36/734A61P3/10A61P5/50A23L33/10A23L33/105A23L33/175A61K2236/333A61K2236/39A23V2002/00A61K2300/00A23V2200/328A23V2250/026A23V2250/0644A23V2250/21A23V2250/2112
Inventor 钱丽霞
Owner 博生众康(厦门)医药生物技术股份有限公司