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Nano particle of core-shell structure with amorphous Fe coated with crystalline Fe3O4 and preparation method and application of nano particle

A nanoparticle, core-shell structure technology, applied in the field of magnetic nanomaterials, to achieve the effect of controllable shape, uniform particle size, and suppression of T2 effect

Inactive Publication Date: 2020-01-03
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The material particle size is about 13.4nm, Fe core and Fe 3 o 4 The shells all have crystalline phases, unfortunately, the material is only imaged with T 2 Contrast function

Method used

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  • Nano particle of core-shell structure with amorphous Fe coated with crystalline Fe3O4 and preparation method and application of nano particle
  • Nano particle of core-shell structure with amorphous Fe coated with crystalline Fe3O4 and preparation method and application of nano particle
  • Nano particle of core-shell structure with amorphous Fe coated with crystalline Fe3O4 and preparation method and application of nano particle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) First measure 15 mL of octadecene in a three-necked flask, and add 0.3 mL of oleylamine;

[0037] (2) Then stir while heating, and discharge air into the three-necked bottle with nitrogen, raise the temperature to 185-190°C, and replace the nitrogen balloon for protection;

[0038] (3) Add 0.7 mL of iron source solution (i.e. iron pentacarbonyl) to it, and react for 28 minutes;

[0039] (4) Add 0.3mL oleic acid, react for 10min, continue to heat up to 260°C, crystallize for 40min, cool down, centrifuge, and the reaction ends to obtain crystalline Fe 3 o 4 Nanoparticles coated with amorphous Fe core-shell structure.

[0040] Such as Figure 1a As shown, the prepared 8nm Fe@Fe 3 o 4 The particle size of nanoparticles is ultra-small and uniform, with good dispersion and no agglomeration.

[0041] Such as figure 2 As shown, Fe 3 o 4 Correspondingly, there is no obvious Fe peak, indicating that the Fe core is amorphous, and the outermost Fe 3 o 4 The shell pre...

Embodiment 2

[0046] (1) First measure 15 mL of octadecene in a three-necked flask, and add 0.2 mL of oleylamine;

[0047] (2) Then stir while heating, and discharge air into the three-necked bottle with nitrogen, raise the temperature to 180-185°C, and replace the nitrogen balloon for protection;

[0048] (3) Add 0.7mL iron source solution (i.e. iron pentacarbonyl) to it, and react for 22min;

[0049] (4) Add 0.2mL oleic acid, react for 10min, continue to heat up to 260°C, crystallize for 40min, cool down, centrifuge, and the reaction is over to obtain crystalline Fe 3 o 4 Nanoparticles coated with amorphous Fe core-shell structure.

[0050] Such as Figure 1b As shown, the prepared 4nm Fe@Fe 3 o 4 The particle size of nanoparticles is ultra-small and uniform, with good dispersion and no agglomeration.

[0051] Such as figure 2 As shown, Fe 3 o 4 Correspondingly, there is no obvious Fe peak, indicating that the Fe core is amorphous, and the outermost Fe 3 o 4 The shell presents...

Embodiment 3

[0056] (1) First measure 20 mL of octadecene in a three-necked flask, and add 0.3 mL of oleylamine;

[0057] (2) Then stir while heating, and discharge air into the three-necked bottle with nitrogen, raise the temperature to 186-190°C, and replace the nitrogen balloon for protection;

[0058] (3) Add 0.7mL iron source solution (i.e. iron pentacarbonyl) to it, and react for 25min;

[0059] (4) Add 0.3mL oleic acid, react for 10min, cool down, centrifuge, the reaction is over, crystalline Fe 3 o 4 Nanoparticles coated with amorphous Fe core-shell structure.

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Abstract

The invention relates to a nano particle of a core-shell structure with amorphous Fe coated with crystalline Fe3O4 and preparation method and application of the nano particle. The synthesized ultra-small Fe@Fe3O4 nano particle with Fe core which is amorphous, while a Fe3O4 shell formed by surface oxidation is crystalline under high temperature treatment, so that the whole nano particle has suitable magnetic strength, and compared with a crystalline Fe core, the amorphous Fe core is more likely to form ultra-small particle size through pyrolysis, and the small size effect and surface effect cause magnetic nanoparticles to have the low Curie temperature, so that the T2 effect is effectively inhibited, and the T1 contrast effect is maximized, and thus T1-T2 dual-mode imaging is achieved, andthe accuracy of diagnosis is improved through complementary T1-T2 dual-mode weighted MRI images.

Description

technical field [0001] The invention relates to the field of magnetic nanomaterials, in particular to a crystalline Fe 3 o 4 Nanoparticles coated with amorphous Fe core-shell structure, its preparation method and application. Background technique [0002] Magnetic resonance imaging (MRI) can detect the longitudinal relaxation time (T 1 ) and transverse relaxation time (T 2 ), mainly used in biomedical diagnosis, has many advantages such as strong penetrability, high spatial resolution, no damage, no radiation, no invasiveness, and can track three-dimensional dynamic imaging, making medical diagnosis more convenient and effective . However, its sensitivity is relatively low in clinical practice, and it cannot accurately distinguish some normal physiological tissues from diseased tissues. Therefore, it is necessary to use intravenous or oral drugs, namely contrast agents (CAs), to enhance the contrast between normal tissues and lesions. [0003] At present, the commonly u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06A61K49/18B82Y30/00B82Y40/00C01G49/08
CPCA61K49/06A61K49/183B82Y30/00B82Y40/00C01G49/08C01P2004/32C01P2004/64C01P2004/80
Inventor 杨仕平刘冬琳李娇娇田启威安璐
Owner SHANGHAI NORMAL UNIVERSITY
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