Preparation method for synthesizing nano sulfadiazine copper

A technology of copper sulfadiazine and sulfadiazine, which is applied in the field of synthesis of copper sulfadiazine, can solve the problems of large particle size of copper sulfadiazine, and achieve complete organizational structure and appearance, small particle size, and guaranteed efficacy Effect

Inactive Publication Date: 2020-01-03
XIAN TECHNOLOGICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, the present invention provides a preparation method for synthesizing nano copper sulfadiazine for the problem of large particle size of existing nano copper sulfadiazine

Method used

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  • Preparation method for synthesizing nano sulfadiazine copper
  • Preparation method for synthesizing nano sulfadiazine copper
  • Preparation method for synthesizing nano sulfadiazine copper

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The steps of a preparation method for synthesizing nano copper sulfadiazine are:

[0023] Step 1: Preparation of sulfadiazine ammonium salt solution

[0024] Weigh 10g of sulfadiazine powder and dissolve it in about 25ml of 10% dilute ammonia water, and the reaction temperature is between 25°C to obtain a light yellow transparent liquid to obtain sulfadiazine ammonium salt;

[0025] Step 2: Preparation of Copper Ammine Solution

[0026] Weigh 5g of copper sulfate pentahydrate, dissolve it with distilled water to obtain a copper sulfate solution, add about 20ml of dilute ammonia water with a concentration of 10%, and the reaction temperature is between 25°C to obtain a clear solution, that is, a copper ammonia complex solution;

[0027] Step 3: Synthesis of copper sulfadiazine

[0028] Slowly add the copper ammonia complex solution into the sulfadiazine ammonium salt solution in the form of stirring while feeding, control the reaction temperature at 25°C, and filter im...

Embodiment 2

[0035] Step 1: Preparation of sulfadiazine ammonium salt solution

[0036] Weigh 10g of sulfadiazine powder and dissolve it in about 25ml of 10% dilute ammonia water, and the reaction temperature is between 30°C to obtain a light yellow transparent liquid to obtain sulfadiazine ammonium salt.

[0037] Step 2: Preparation of Copper Ammine Solution

[0038] Weigh 5g of copper sulfate pentahydrate, dissolve it in distilled water to obtain a copper sulfate solution, add about 20ml of 10% dilute ammonia water, and keep the reaction temperature between 30°C to obtain a clear solution, that is, a copper ammonia complex solution.

[0039] Step 3: Synthesis of copper sulfadiazine

[0040] Slowly add the copper ammonia complex solution into the sulfadiazine ammonium salt solution, stir while adding, control the reaction temperature at 30°C, and filter immediately after reacting for 3 minutes;

[0041] Step 4: Wash the sediment and pre-freeze

[0042] Add the filtered copper sulfadiaz...

Embodiment 3

[0047] Step 1: Preparation of sulfadiazine ammonium salt solution

[0048] Weigh 10g of sulfadiazine powder and dissolve it in about 25ml of 10% dilute ammonia water, and the reaction temperature is between 20°C to obtain a light yellow transparent liquid to obtain sulfadiazine ammonium salt.

[0049] Step 2: Preparation of Copper Ammine Solution

[0050] Weigh 5g of copper sulfate pentahydrate, dissolve it in distilled water to obtain a copper sulfate solution, add about 20ml of dilute ammonia water with a concentration of 10%, and keep the reaction temperature between 20°C to obtain a clear solution, that is, a copper ammonia complex solution.

[0051] Step 3: Synthesis of copper sulfadiazine

[0052] Slowly add the copper ammonia complex solution into the sulfadiazine ammonium salt solution, stir while adding, control the reaction temperature at 20~30°C, and filter immediately after reacting for 5 minutes;

[0053] Step 4: Wash the precipitate with water

[0054] Add the...

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Abstract

The invention relates to a preparation method for synthesizing nano sulfadiazine copper. The invention aims to solve the problem of large particle size of the existing nano sulfadiazine copper. The adopted technical scheme is as follows: the method comprises the following steps: slowly adding a copper-ammonia complex solution into a sulfadiazine ammonia salt solution in a form of feeding while stirring to react; controlling the reaction temperature to be 20-30 DEG C; immediately filtering after reacting for 3-5 minutes; adding distilled water into the filtered sulfadiazine copper, repeatedly cleaning until the pH value of the filtrate is 7, then pre-freezing the washed sulfadiazine copper powder to be lower than the eutectic point temperature, putting the pre-frozen sulfadiazine copper powder into a drying chamber of a vacuum freeze dryer for drying, taking out a sample after the sulfadiazine copper powder is completely dried, and packaging the sample in vacuum.

Description

technical field [0001] The invention relates to a preparation method for synthesizing nano copper sulfadiazine. Background technique [0002] Copper sulfadiazine is an odorless, green crystalline powder obtained from the reaction of sulfadiazine ammonium salt and copper complex. Copper sulfadiazine is insoluble in water, ethanol, chloroform and ether, and easily soluble in dilute hydrochloric acid and ammonia solution. [0003] The existing preparation method of sulfadiazine copper is mainly the hot air drying method, and the obtained sulfadiazine copper powder has a relatively large particle size, which is prone to agglomeration, making the human body's absorption effect of the drug poor, and high-temperature drying will have certain effects on the activity of the drug. The impact of this greatly limits the body's absorption of medicinal properties. Contents of the invention [0004] In view of this, the present invention provides a preparation method for synthesizing n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/69
CPCC07D239/69
Inventor 彭润玲杨杰肖明春曹蔚郭俊德王鹏
Owner XIAN TECHNOLOGICAL UNIV
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