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UV optical adhesive and uses as pathological section sealing adhesive

A technology for optical adhesives and uses, which is applied in the direction of material analysis, adhesives, and scientific instruments through optical means. It can solve the problems of shortening the drying time and achieve the effects of improving efficiency, good application prospects, and increasing drying speed.

Active Publication Date: 2020-01-07
SHANDONG JUNTENG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the drying time of the UV optical glue disclosed in this patent is significantly shortened compared with the traditional neutral resin mounting agent, there is still room for further improvement.

Method used

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  • UV optical adhesive and uses as pathological section sealing adhesive
  • UV optical adhesive and uses as pathological section sealing adhesive
  • UV optical adhesive and uses as pathological section sealing adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the preparation of UV optical glue of the present invention

[0031] In the UV optical adhesive of the present invention, polyethylene glycol methyl ether acrylate is used as a prepolymer, vinyl acetate is used as a reactive diluent, and 2-hydroxyl-2-methyl-1-phenyl-1-acetone is used as photoinitiator.

[0032] The specific preparation method is as follows: according to the formula shown in Table 1, measure each raw material respectively, mix them evenly, and obtain the product.

[0033] Table 1. UV Optical Adhesive Formulation (mL)

[0034]

[0035]

[0036] The beneficial effects of the present invention are demonstrated through experimental examples below.

experiment example 1

[0037] Experimental example 1. Drying time test of UV optical glue

[0038] 1. Experimental method

[0039] (1) Test materials: the UV optical adhesive prepared in Example 1; neutral resin mounting agent (Thermo ClearVue mounting agent; product number 4212; batch number 406379);

[0040] (2) Slicing production:

[0041] a. Grouping: Take 10 HE-stained pathological slides that have been stained, divide them into 2 groups (neutral resin group, UV optical glue group), and mark them;

[0042] b. Mounting: According to the section grouping, drop the same volume of neutral resin mounting agent and the UV optical glue prepared in Example 1 on the slide, then cover with a cover glass, and place carefully after sealing drying plate;

[0043] (3) Drying: After the neutral resin group is sealed, put it in a ventilated place at room temperature to dry and cure naturally. After the UV optical glue group is sealed, put it into an ultraviolet light irradiation device (DEYIWISE UV glue cur...

experiment example 2

[0050] Experimental example 2. Test of the sealing effect of UV optical glue

[0051] 1. Experimental method

[0052] (1) Use the UV optical glue (sample 42) and neutral resin mounting agent prepared in Example 1 to mount the following stained paraffin pathological sections: HE staining, Masson staining, glycogen staining, formazan Aniline blue staining, Sirius red staining, and immunohistochemical staining, and then collect images to observe the effect of sectioning after mounting.

[0053] (2) UV optical glue (sample 42) and neutral resin mounting agent prepared in Example 1 are used to mount the following frozen pathological sections that have been stained: HE staining, then collect images, observe after mounting slice effect.

[0054](3) After sealing the HE-stained pathological sections with the UV optical glue (sample 42) prepared in Example 1, the images were collected; stored at room temperature under dry and ventilated conditions for 2 years, and the images were col...

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PUM

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Abstract

The invention provides a UV optical adhesive, which is prepared from the following raw materials by volume: 3.0-11.0 parts of a prepolymer, 0.5-5.0 parts of an active diluent and 0.1-1.5 parts of a photoinitiator, wherein the prepolymer is a prepolymer containing unsaturated double bonds. According to the invention, the UV optical adhesive can be quickly dried within 10-30 sunder the irradiation of ultraviolet light; compared with the traditional neutral resin section sealing adhesive, theUV optical adhesive has the substantially shortened drying time so as to substantially improve the pathological section manufacturing efficiency; and the dried UV optical adhesive has advantages of high-temperature resistance, high-pressure resistance, long-term storage resistance and no discoloration, can still keep the clear color of pathological sections after being stored for more than two years, and has good application prospects in pathological section preparation.

Description

technical field [0001] The invention relates to a UV optical glue and its application as a pathological slice sealing glue. Background technique [0002] In the production process of traditional pathological slides, the last step is to use mounting glue to bond the cover glass and the slide glass together. This process is called mounting the slide. The purpose of sealing the slides is to protect the slices from contact with air and prevent them from oxidative fading or discoloration. The mounting agent needs to meet high light transmittance and high transparency, maintain the original color of the slice, and facilitate the reading and judgment of the film reader; at the same time, the mounting agent also needs to meet the stability of not deteriorating for a long time. [0003] The mounting glue used in the work of the pathology department is neutral resin mounting agent or neutral quick-drying glue. After the sealing is completed, it is usually dried naturally, and it take...

Claims

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Application Information

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IPC IPC(8): C09J4/02G01N1/28G01N21/84
CPCC09J4/00G01N1/28G01N1/2813G01N21/84
Inventor 包骥步宏周燕燕张炳琪李丽陈菲罗添友邓杨
Owner SHANDONG JUNTENG MEDICAL TECH CO LTD
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