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Application of codonopsis pilosula astragalus membranaceus and schisandrae chinensis preparation in treatment and/or prevention of anorexia nervosa

Anorexia, neurological technology, applied in the field of medicine, can solve the problems of limited therapeutic effect and large side effects, and achieve the effect of stable curative effect

Inactive Publication Date: 2020-01-10
甘肃普泽医药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, most of the treatments for anorexia nervosa on the market are western medicines, which have limited therapeutic effects and relatively large side effects; traditional Chinese medicines are mostly formulated for the digestive system, such as invigorating the spleen and stomach, and passively increasing appetite. It is difficult to fundamentally solve the problem.

Method used

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  • Application of codonopsis pilosula astragalus membranaceus and schisandrae chinensis preparation in treatment and/or prevention of anorexia nervosa
  • Application of codonopsis pilosula astragalus membranaceus and schisandrae chinensis preparation in treatment and/or prevention of anorexia nervosa

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 Pharmacodynamics test

[0039] Effects of Shenqi Wuweizi Tablets on Plasma Brain Gut Peptide in Rats with Anorexia

[0040] Research data show that CCK-8 with anorexigenic effect and β-EP with anorexic effect play an important role in the physiological regulation of food intake and pathological food intake reduction.

[0041] 1. Experimental animals:

[0042] 24 35-40d old rats, half male and half male, body weight 60±10g.

[0043] 2. Instruments, reagents and medicines:

[0044] γ automatic radioimmunoassay apparatus; neuropeptide CCK-8 radioimmunoassay kit, neuropeptide β-EP radioimmunoassay kit; aprotinin, anticoagulant.

[0045] Preparation of test drug: 18g of Radix Astragali, 3g of Jujube Seed, and 12g of Schisandra chinensis were percolated according to the percolation method, and 30%, 50%, and 70% ethanol were used as solvents for percolation. ; Crush 6g of Codonopsis pilosula and 6g of Schisandra chinensis into fine powder, add clear paste, mix...

Embodiment 2

[0067] Summary of embodiment 2 clinical trials

[0068] 1. Diagnostic criteria

[0069] 1.1 Diagnostic criteria of traditional Chinese medicine: refer to "Gastroenterology of Traditional Chinese Medicine" (Edited by Li Qiangou, Science Press, 2012)

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Abstract

The invention belongs to the field of medicine, and particularly relates to an application of a traditional Chinese medicine composition in treatment and / or prevention of anorexia nervosa. The purposeof the invention is to apply the traditional Chinese medicine composition with effects of invigorating a spleen, benefiting qi, calming a heart and tranquilizing a mind to a brand new application totreat the liver depression, spleen deficiency and heart-spleen deficiency type anorexia nervosa. The pharmaceutical composition takes kadsura longepedunculata, codonopsis pilosula, astragalus membranaceus and spina date seeds as crude drugs and comprises the following components in parts by weight: 6-30 parts of the schisandrae chinensis (kadsura japonica or fructus schisandrae chinensis), 1-15 parts of the codonopsis pilosula, 4-24 parts of the astragalus membranaceus and 0.5-15 parts of the spina date seeds (fried). The pharmaceutical composition provided by the invention has good clinical effects on insomnia, dreaminess, amnesia, weakness, palpitation, shortness of breath, spontaneous perspiration and the like caused by liver depression, spleen deficiency and heart-spleen deficiency, particularly has a definite effect on the anorexia nervosa, and is stable in curative effect, safe, controllable and small in toxic and side effects.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a traditional Chinese medicine composition in treating and / or preventing anorexia nervosa. Background technique [0002] Anorexia nervosa (AN) refers to an eating disorder characterized by individuals deliberately causing and maintaining a body weight significantly lower than normal standards through dieting and other means, and belongs to the category of "physiological disorders related to psychological factors" in the field of psychiatry. Its main feature is the extreme focus on weight and body shape characterized by strong fear of weight gain and obesity, blind pursuit of slimness, significant weight loss, often malnutrition, metabolic and endocrine disorders, such as amenorrhea in women. Severe patients may experience cachexia and body failure due to extreme malnutrition, thereby threatening their lives. 5% to 15% of patients eventually die of cardiac co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P1/14A61K33/26
CPCA61K33/26A61K36/13A61K36/185A61K36/232A61K36/258A61K36/28A61K36/45A61K36/47A61K36/48A61K36/482A61K36/489A61K36/60A61K36/605A61K36/638A61K36/752A61K36/77A61K36/804A61K36/8888A61K36/9066A61K36/9068A61K2236/333A61K2236/51A61P1/14A61K2300/00
Inventor 姚文
Owner 甘肃普泽医药有限责任公司
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