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Externally used pharmaceutical composition for skin and preparation method thereof

A technology of external medicine and composition, which is applied in the field of pharmaceutical composition for skin diseases, can solve problems such as unsatisfactory effect of promoting healing, and achieve the effects of preventing hand and foot rupture, good permeability, and low surface tension

Pending Publication Date: 2020-01-14
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the improvement of symptoms such as bleeding and pain caused by skin lesions and the effect of promoting healing are not ideal.

Method used

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  • Externally used pharmaceutical composition for skin and preparation method thereof
  • Externally used pharmaceutical composition for skin and preparation method thereof
  • Externally used pharmaceutical composition for skin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0058] An external pharmaceutical composition cream preparation suitable for dry skin, chapped skin and palmar keratosis, the preparation method of which is as follows:

[0059] Step 1), prepare materials by the weight of Form 1 formula;

[0060] Step 2), put the water phase (urea, glycerin, preservative, purified water) and emulsifier (triethanolamine) in a stainless steel container, heat to melt, and keep the temperature at 70°C;

[0061] Step 3), the oil phase (progesterone, mink oil, stearic acid, "glyceryl mono- and distearate", stearyl alcohol, liquid paraffin, Vaseline Tween 80) is placed in a stainless steel container, and the temperature is constant to 70 ℃;

[0062] Step 4), slowly add the water phase obtained in step 2) to the oil phase obtained in step 3), and stir in the same way. After stirring for 2 hours, cool to room temperature, then add other additives, and condense to obtain the cream .

[0063] Table 1

[0064]

[0065]

Embodiment 6-8

[0067] An external pharmaceutical composition gel preparation suitable for dry skin, chapped skin and palmar keratoderma, the preparation method of which is as follows:

[0068] Step 1) prepare materials by the weight of formula shown in table 2;

[0069] Step 2) Take 50-200mL of purified water, first add co-solvent, then add active components (urea, progesterone and mink oil), stir evenly to obtain liquid A;

[0070] Step 3) disperse and cool the thickener with 50-200mL purified water to obtain liquid B;

[0071] Step 4) Dissolve preservatives and essence in another 5-20mL of purified water, stir well and filter to obtain liquid C.

[0072] Step 5) Combine the two liquids B and C, then add the dissolved liquid A, add purified water to the full amount, and obtain a gel.

[0073] Table 2

[0074]

Embodiment 9-11

[0076] An external pharmaceutical composition ointment preparation suitable for dry skin, chapped skin and palmar keratosis, the preparation method of which is:

[0077] Step 1), prepare materials according to the formula shown in table 3;

[0078] Step 2), take 20-80mL purified water, first add co-solvent, add urea, progesterone and mink oil, stir to dissolve;

[0079] Step 3), add an appropriate amount of liquid paraffin, grind into a fine paste, and pass through a 200-mesh sieve;

[0080] Step 4), then gradually add the mixture of lanolin and yellow petrolatum, and mix well to obtain the ointment.

[0081] table 3

[0082]

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PUM

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Abstract

The invention provides an externally used pharmaceutical composition for skin dryness, fissures and palmar keratosis, and a preparation method thereof. The pharmaceutical composition comprises the following active ingredients in parts by weight: 100-2000 parts of urea, 0.1-1 part of progesterone and 100-1000 parts of mink oil. The pharmaceutical composition can be made into externally used preparations including creams, ointments, gels, or any one of pharmacologically acceptable preparations for external use in combination with pharmacologically acceptable excipients. The pharmaceutical composition of the present invention is suitable for treating skin problems such as skin dryness, fissures and palmar keratosis, and has better curative effect and less side effect than ordinary urea dosageforms for external use.

Description

technical field [0001] The present invention designs medical preparations, in particular relates to pharmaceutical compositions for treating skin diseases such as dry skin, chapped skin and palmar keratosis. Background technique [0002] Dry skin and chapped skin are common skin diseases. They tend to occur in exposed parts of the skin such as hands and feet. The damage is cracks of different sizes and depths. The occurrence of the disease is related to epidermal thickening, dryness, external stimulation and local activity. In mild cases, the disease only involves the epidermis and affects the appearance of the skin; in severe cases, it can penetrate deep into the dermis and subcutaneous tissue, causing bleeding, pain, affecting local functional activities, bringing pain to the patient, and affecting the normal work and life of the patient. With the development of society, people's social activities are more and more frequent, and dry and chapped skin also brings embarrassm...

Claims

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Application Information

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IPC IPC(8): A61K35/35A61K9/06A61P17/00A61P17/02A61K31/17A61K31/57
CPCA61K35/35A61K31/17A61K31/57A61K9/06A61K9/0014A61K47/44A61K47/06A61K47/10A61P17/00A61P17/02A61K2300/00
Inventor 伍俊妍李国成余晓霞刘春霞邱凯锋区杰彬王莹
Owner SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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