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Core/Shell Composite Fiber and Method for Making the Same

A composite fiber and composite material technology, applied in the chemical characteristics of fibers, conjugated synthetic polymer rayon, textiles and papermaking, etc., can solve problems such as insufficient mechanical strength, and achieve good mechanical properties and stability.

Active Publication Date: 2022-04-15
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a core / shell composite fiber and its preparation method, aiming to solve the problem of insufficient mechanical strength of existing hydrogel materials in wet state

Method used

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  • Core/Shell Composite Fiber and Method for Making the Same
  • Core/Shell Composite Fiber and Method for Making the Same
  • Core/Shell Composite Fiber and Method for Making the Same

Examples

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preparation example Construction

[0035] The first aspect of the embodiments of the present invention provides a method for preparing a core / shell composite fiber, comprising the following steps:

[0036] S01. Dissolving the synthetic polymer material in an organic solvent, mixing and processing, and preparing a synthetic polymer slurry; wherein, the organic solvent used to disperse the synthetic polymer is a water-soluble organic solvent; obtaining a hydrogel slurry ;

[0037]S02. The synthetic polymer slurry and the hydrogel slurry are loaded into a 3D printing device with dual-channel coaxial extrusion, and connected with a dual-channel needle, and the synthetic polymer slurry is connected to the inner channel, so The hydrogel slurry is connected to the outer channel, and the extrusion pressure of the inner and outer channels is adjusted, so that the hydrogel of the outer channel and the synthetic polymer of the inner channel are extruded synchronously, and a composite material with a core / shell structure i...

Embodiment 1

[0072] A preparation method of core / shell composite fiber, comprising the following steps:

[0073] Add PLGA into dioxane under stirring condition, and keep stirring for 24 hours after sealing to obtain 80% (w / v) PLGA inner core slurry. Dissolve polylysine in deionized water and stir well. Using sodium hydroxide solution to adjust the pH value of the polylysine solution to neutral, then adding sodium alginate and stirring evenly to obtain polylysine-composite alginate hydrogel shell slurry. The molar ratio of the amino group of polylysine to the carboxyl group of sodium alginate is 1:1, and the total mass fraction of the hydrogel is 40% (w / v). At room temperature, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), N-hydroxysuccinimide (NHS), sodium chloride, morpholine Add ethanesulfonic acid into deionized water and stir evenly to obtain EDC / NHS crosslinking agent. Wherein, the concentrations of the four components are 9.6% (w / v), 2.9% (w / v), 2.9% (w / v), an...

Embodiment 2

[0077] A preparation method of core / shell composite fiber, comprising the following steps:

[0078] Add PLGA into dioxane under stirring condition, and keep stirring for 24 hours after sealing to obtain 80% (w / v) PLGA inner core slurry. Dissolve polylysine in deionized water and stir well. Using sodium hydroxide solution to adjust the pH value of the polylysine solution to neutral, then adding sodium alginate and stirring evenly to obtain polylysine-composite alginate hydrogel shell slurry. The molar ratio of the amino group of polylysine to the carboxyl group of sodium alginate is 1:1, and the total mass fraction of the hydrogel is 40% (w / v). At room temperature, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), N-hydroxysuccinimide (NHS), sodium chloride, morpholine Add ethanesulfonic acid into deionized water and stir evenly to obtain EDC / NHS crosslinking agent. Wherein, the concentrations of the four components are 9.6% (w / v), 2.9% (w / v), 2.9% (w / v), an...

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Abstract

The invention provides a method for preparing a core / shell composite fiber, comprising: dissolving a synthetic polymer material in an organic solvent, mixing and processing, and preparing a synthetic polymer slurry; combining the synthetic polymer slurry and the hydrogel slurry Put it into a 3D printing device with dual-channel coaxial extrusion, and connect it with a dual-channel needle. The synthetic polymer slurry is connected to the inner channel, and the hydrogel slurry is connected to the outer channel. Adjust the extrusion pressure of the inner and outer channels to make the outer channel water Synchronous extrusion of the gel and the inner channel synthetic polymer to obtain a composite material with a core / shell structure; the obtained composite material with a core / shell structure is placed in an aqueous solution of a crosslinking agent to cause a crosslinking reaction of the shell hydrogel , and the organic solvent in the core synthetic polymer is extracted by the water phase in the crosslinking agent aqueous solution, the core synthetic polymer is solidified, and the core / shell composite fiber is obtained. The core / shell fibers provided by the present invention can further construct 3D printing scaffolds.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a core / shell composite fiber and a preparation method thereof. Background technique [0002] Under the national conditions of an aging population, the clinical demand for tissue / organ repair and regeneration continues to increase, and research on innovative treatment methods is imperative. Taking orthopedics as an example, large bone defects, osteoporotic fractures, and nonunions generally face problems related to donor sources and treatment effects. At the molecular and cellular levels, the essence of tissue / organ repair and regeneration is to rebuild the microenvironment of cell survival and function at the treatment site to achieve a healthy level. Therefore, restorative materials need to achieve functional design and precise manufacturing simultaneously. In terms of functional design, it should imitate the extracellular matrix environment to provide a good ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F8/14D01F8/12D01F8/18
CPCD01F8/14D01F8/12D01F8/18
Inventor 程德林阮长顺洪毅姜陈必秀潘浩波吴明明
Owner SHENZHEN INST OF ADVANCED TECH