A kind of sulfur quantum dot/manganese dioxide nanosheet composite material and its preparation method and application

A manganese dioxide and composite material technology, applied in the field of nano-analysis, can solve the problems of low detection sensitivity of BchE, toxicity of detection materials and reagents, etc., and achieve the effects of strong anti-interference ability, low biological toxicity and wide detection range.

Active Publication Date: 2022-06-03
HEBEI UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] One of the purposes of the present invention is to provide a sulfur quantum dot / manganese dioxide nanosheet composite material to solve the problems of low detection sensitivity of existing BchE and the toxicity of detection materials and reagents

Method used

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  • A kind of sulfur quantum dot/manganese dioxide nanosheet composite material and its preparation method and application
  • A kind of sulfur quantum dot/manganese dioxide nanosheet composite material and its preparation method and application
  • A kind of sulfur quantum dot/manganese dioxide nanosheet composite material and its preparation method and application

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Experimental program
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Embodiment 1

[0071] Mix 2.5 μL of sulfur quantum dot solution with 14 μL of manganese dioxide nanosheet aqueous solution, add deionized water to make the total volume of the system 60 μL, so that the concentration of sulfur quantum dots is 6.67 mg / mL, and the concentration of manganese dioxide nanosheets is 163.3 μg / mL, using NaOH aqueous solution to adjust the pH of the mixed solution to 7.1, and reacting at 30 °C for 1 hour to obtain the sulfur quantum dot / manganese dioxide nanosheet composite material.

[0072] After the obtained product was ultrasonically dispersed and mixed in a certain proportion, it was dropped on a copper mesh, and then air-dried naturally. The sulfur quantum dots / manganese dioxide nanosheet composites were characterized by TEM-Mapping, and the obtained results were as follows: Figures 5~8 shown. It can be seen from the figure that the sulfur quantum dots / manganese dioxide nanosheet composites were successfully synthesized, and the sulfur quantum dots were uniform...

Embodiment 2

[0074] Mix 2.5 μL sulfur quantum dot solution with 14 μL manganese dioxide nanosheet aqueous solution, add deionized water to make the total volume of the system 60 μL, so that the concentration of sulfur quantum dots is 4 mg / mL, and the concentration of manganese dioxide nanosheets is 163.3 μg / mL, adjust the pH of the mixed solution to 7.1, and react at 30 °C for 1 hour to obtain the sulfur quantum dot / manganese dioxide nanosheet composite material.

Embodiment 3

[0076] Mix 2.5 μL of sulfur quantum dot solution with 14 μL of manganese dioxide nanosheet aqueous solution, add deionized water to make the total volume of the system 60 μL, so that the concentration of sulfur quantum dots is 6.67 mg / mL, and the concentration of manganese dioxide nanosheets is 116.7 μg / mL, adjust the pH of the mixed solution to 7.1, and react at 30 °C for 1 hour to obtain the sulfur quantum dot / manganese dioxide nanosheet composite material.

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Abstract

The invention provides a sulfur quantum dot / manganese dioxide nanosheet composite material and its preparation method and application. The sulfur quantum dots are evenly distributed on the manganese dioxide nanosheet. It is obtained by mixing the aqueous solution of sulfur quantum dots with the aqueous solution of manganese dioxide nanosheets with a concentration of 116-187 μg / mL, adjusting the pH to 3-9.5, and then reacting. The preparation method of the composite material of the present invention is simple, the product yield is high, the obtained composite material is non-toxic, has good biocompatibility, wide detection range, high sensitivity, strong anti-interference ability, and has piecewise linear characteristics in the range of low concentration and high concentration. The ultrasensitive detection of substances such as cholinesterase, substances containing cholinesterase, and pesticides with an inhibitory effect on cholinesterase can be realized, and has wide potential application value.

Description

technical field [0001] The invention relates to the field of nanometer analysis, in particular to a sulfur quantum dot / manganese dioxide nanosheet composite material and a preparation method and application thereof. Background technique [0002] Cholinesterase is a type of glycoprotein that exists in the human body in the form of a variety of isozymes. It is generally divided into acetylcholinesterase and butyrylcholinesterase. Among them, butyrylcholinesterase (BChE for short) ), also known as serum cholinesterase, catalyzes the hydrolysis of butyrylcholine. The content of BChE in serum has predictive value for the early diagnosis and disease progression of patients with coronary heart disease and Alzheimer's disease. [0003] The most classic and commonly used technique for BChE detection is the Ellman-reagent method. The detection principle is based on the fact that BChE can specifically catalyze the decomposition of thiobutyrylcholine to generate thiocholine and further...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64
CPCG01N21/6402
Inventor 王振光李天姿翟永清史玉娥吕运开邓奎林
Owner HEBEI UNIVERSITY
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