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Preparation method and application of inonotus obliquus extract granules

A technology of Inonotus obliquus and granules, applied in the field of Inonotus obliquus extracts, can solve problems such as insufficient research reports, achieve high content of Inonotus obliquus polysaccharides, be convenient to carry and transport, and be conducive to popularization and application Effect

Inactive Publication Date: 2020-01-24
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no sufficient research reports on the specific preparation and preparation of the granules of the Inonotus obliquus extract and its use in the treatment and / or prevention of myocardial ischemia-reperfusion injury

Method used

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  • Preparation method and application of inonotus obliquus extract granules
  • Preparation method and application of inonotus obliquus extract granules
  • Preparation method and application of inonotus obliquus extract granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: the preparation method of Inonotus obliquus extract

[0026] Precisely weigh 100g of Inonotus obliquus medicinal material, pulverize it, pass through a 40-mesh sieve, add 1000mL of water, take a water bath at 80°C, extract for 2 hours, collect the supernatant after filtering through 3 layers of gauze, repeat twice, and finally combine the obtained supernatant, Vacuum and dry under reduced pressure to obtain the extract of Inonotus obliquus. The polysaccharide content is 2.83%.

example 2

[0027] Example 2: the preparation method of Inonotus obliquus extract

[0028] Precisely weigh 100g of Inonotus obliquus medicinal material, crush it, pass through a 60-mesh sieve, add 800mL of 20% ethanol, bathe in 80°C water, extract for 2 hours, collect the supernatant after filtering through 3 layers of gauze, repeat twice, and finally combine the obtained supernatants liquid, dried under reduced pressure in vacuo to obtain Inonotus obliquus extract. The polysaccharide content is 2.48%.

example 3

[0029] Example 3: The preparation method of Inonotus obliquus extract

[0030] Precisely weigh 100g of Inonotus obliquus medicinal material, pulverize it, add 1200mL of 50% ethanol, take a water bath at 80°C, extract for 2 hours, collect the supernatant after filtering through 3 layers of gauze, repeat twice, finally combine the obtained supernatant, and vacuum decompress Dried to obtain the Inonotus obliquus extract. The polysaccharide content is 2.08%.

[0031] Adopt low-temperature microwave vacuum drying equipment in the present invention, its advantage is the following points: 1. Conventional vacuum drying equipment all adopts steam to heat, needs to heat from inside to outside, and heating rate is slow and needs to expend a large amount of coal, and microwave vacuum The drying equipment adopts electromagnetic wave heating, without heat transfer medium, directly heating to the inside of the object, with fast heating speed, high efficiency, greatly shortened drying cycle,...

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PUM

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Abstract

The invention relates to a preparation method and application of inonotus obliquus extract granules, and belong to the technical field of production of drugs. The inonotus obliquus extract granules are prepared through steps of performing water extraction on inonotus obliquus, and then adding a diluent, a lubricant, a correctant and an adhesive so that the inonotus obliquus extract granules are prepared. The invention further discloses the action of the inonotus obliquus granules to treatment and / or prevention of myocardial ischemia reperfusion damage.

Description

Technical field: [0001] The invention belongs to the technical field of medicine production and relates to an extract of Inonotus obliquus. Background technique: [0002] The incidence of cardiovascular disease is increasing at an alarming rate worldwide. According to the World Health Organization report in 2010, 17.1 million people die from cardiovascular diseases worldwide every year, accounting for 29% of all deaths worldwide. Myocardial ischemia can cause irreversible damage to the myocardium, leading to a variety of cardiovascular diseases, such as myocardial infarction, myocardial hypertrophy, arteriosclerosis, and heart failure. The pathophysiological mechanism of ischemic cardiomyopathy mainly includes microcirculation disturbance, endoplasmic reticulum stress, oxidative stress, inflammation, apoptosis and so on. At present, anti-heart failure drugs are mainly used for the treatment of ischemic cardiomyopathy at home and abroad, but the efficacy is not good. There...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/07A61K9/16A61K47/36A61K47/26A61P9/00A61P9/10
CPCA61K9/1623A61K9/1652A61K36/07A61K2236/331A61K2236/39A61K2236/51A61P9/00A61P9/10
Inventor 武毅薛岩付雯雯高洋邬丹崔贺铭张玉莹于萍孙铭阳
Owner JILIN UNIV
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