Silver-containing wound care solution and preparation method thereof

Abstract

The invention discloses a silver-containing wound care solution and a preparation method thereof. 1000 ml of silver-containing wound care solution comprises 0.07 to 0.4 g of silver-containing compound, 0.01 to 1.0 g of penetration enhancer, 0.1 to 10 g of surfactant, 5 to 40 g of lubricant, 0.05 to 0.5 g of buffer system, 0.03 to 0.3 g of polyacid and 1000 ml of deionized water. The preparation method comprises the following steps: adding the penetration enhancer and the surfactant into the deionized water and stirring into mixed liquid; and adding the mixed liquid in a silver solution, addingthe lubricant and a buffer solution, adding an acid solution and finally adding the deionized water to determine the volume to 1000 ml to obtain the silver-containing wound care solution. The added silver ions have long-term sterilizing effect, is non-toxic, pollution-free and non-irritant, and bacteria and fungi do not have drug resistance; and the content of the silver ions is reduced by guaranteeing effective sterilizing effect, so that the biological safety is guaranteed.

Description

technical field [0001] The invention relates to the technical field of medical sterilization, in particular to a silver-containing wound care solution and a preparation method thereof. Background technique [0002] At present, chronic difficult-to-heal wounds (commonly known as chronic ulcers) can be directly caused by trauma, burns and other accidental injuries, and inhibit wound healing, making wound healing difficult; clinically one of the influencing factors of chronic wound formation is wound infection, and biofilm Formation is the main cause of causing or aggravating chronic infection. It has been reported that 99% of bacteria in nature exist in the form of biofilm, and about 65% of human chronic wound infection and 6% of acute wound infection are related to biofilm. When the wound changed from acute to chronic, this biofilm could be detected in more than 60% of the wound. [0003] Studies have shown that Staphylococcus aureus infection can be detected in 93.5% of chr...

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Problems solved by technology

[0011] The Chinese invention patent with the application number 201010019517 discloses a wound antibacterial rinse and its preparation method. The rinse improves the bactericidal ability by combining chlorhexidine salt, absolute ethanol and silver nitrate, but the chlorhexidine salt is easy to cause allergies, Symptoms such as asthma and dyspnea are irritating to the mucous membranes, and gargling can cause tooth staining, and the bacteria are resistant to it; and ethanol not only cannot completely eliminate the bacteria that grow on the skin, but also has a certain stimulating effect on the wound. Does not moisturize and moisturize the skin

[0012] The Chinese invention patent with application number 200910105563 discloses a nano-silver disinfectant, which uses nano-silver for disinfection and sterilization, but the production process of nano-silver is cumbersome and expensive, which increases production costs, and the reduction ability of silver ions is extremely strong, which can Generate atomic oxygen in the surrounding space to greatly improve the bactericidal effect. The chemical valence state of metallic silver in nano-silver is zero, so the antibacterial performance of silver ions is much higher than that of nano-silver under the same silver content.

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