Mupirocin ointment and preparation method thereof

Abstract

The invention discloses a mupirocin ointment. The ointment is prepared from the following raw materials in parts by weight: 20 to 100 parts of mupirocin, 500 to 700 parts of polyethylene glycol 3350,400 to 600 parts of polyethylene glycol 400, 1 to 2 parts of vitamin E and 39 to 58 parts of propylene glycol. The invention also discloses a preparation method of the mupirocin ointment. The method comprises the following steps: taking the polyethylene glycol 400, adding the polyethylene glycol 3350 and the propylene glycol, and performing uniform mixing to obtain a solution A; taking the polyethylene glycol 400, adding the mupirocin and the vitamin E, and performing uniform mixing to obtain a suspension B; and uniformly mixing the solution A and the suspension B at 55-65 DEG C, cooling obtained mixture to 35-45 DEG C, performing grinding, cooling ground material to room temperature, and performing canning to obtain the ointment. The ointment has uniformly-distributed active ingredients,has proper consistency, is easy to smear, and is convenient for patients to use.

Description

technical field [0001] The invention relates to the technical field of chemical preparations, in particular to a mupirocin ointment and a preparation method thereof. Background technique [0002] Mupirocin Ointment, trade name: It is a new type of topical antibiotic, which is a metabolite produced in the culture medium of Pseudomonas fluorescens, Pseudomonas A. This product was approved by FDA in 1987. The chemical structure and mechanism of action of mupirocin are different from those of other types of antibiotics, and the emergence of drug resistance can be avoided in the near future; it has high activity against common skin Gram-positive bacteria, especially under acidic conditions; it does not produce contact allergy Reaction, non-irritating and toxic, safe to use. It is clinically suitable for primary skin infections such as bacterial infection impetigo, furunculosis, folliculitis, and secondary infections such as eczema combined infection, ulcer combined infection,...

AI Technical Summary

Problems solved by technology

[0004] At present, there are common problems with the consistency of the mupirocin ointment that has been listed on the market. Its bases are mainly polyethylene glycol 3350 and polyethylene glycol 400. The specific ratio can be detected by using a differential detector in high performance liquid chromatography. , but the prepared ointment base has a very thick consistency. Many manufacturers solve this problem by increasing the proportion of polyethylene glycol 400. When the temperature is high in summer, the ointment base is thinner and watery after extrusion; when the temperature is low in winter, the ointment base is low. Very hard, it is not easy to squeeze out from the ointment tube, making the active ingredient API in the mupirocin ointment unevenly distributed in the matrix, affecting the patient's experience and curative effect

Images