Mupirocin ointment and preparation method thereof

A technology of mupirocin and semupirocin, which is applied in the field of chemical pharmaceutical preparations, can solve the problems of uneven distribution of active ingredient API, affecting patients' experience and curative effect, and large consistency of ointment matrix, and achieves rheological properties. Consistent, avoid small lumps, improve the effect of very hard ointment base

Inactive Publication Date: 2020-02-14
FRONT PHARM PLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are common problems with the consistency of the mupirocin ointment that has been listed on the market. Its bases are mainly polyethylene glycol 3350 and polyethylene glycol 400. The specific ratio can be detected by using a differential detector in high performance liquid chromatography. , but the prepared ointment base has a very thick consistency. Many manufacturers solve this problem by increa

Method used

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  • Mupirocin ointment and preparation method thereof
  • Mupirocin ointment and preparation method thereof
  • Mupirocin ointment and preparation method thereof

Examples

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Embodiment 1

[0018] A kind of mupirocin ointment, its raw material comprises by weight: 20 parts of mupirocin, 520 parts of polyethylene glycol 3350, 420 parts of polyethylene glycol 400, 1 part of vitamin E, 39 parts of propylene glycol.

[0019] The preparation method of above-mentioned mupirocin ointment, comprises the steps:

[0020] Take the preparation tank and keep it dry at 85°C for 30 minutes, then add polyethylene glycol 400 to the preparation tank, raise the temperature to 70°C, add polyethylene glycol 3350 and propylene glycol and stir slowly to melt and clarify the polyethylene glycol 3350, and cool down to 65°C °C to obtain solution A;

[0021] Add polyethylene glycol 400 into a stainless steel bucket, then add mupirocin and vitamin E and mix to obtain a suspension B, wherein, rinse the stainless steel bucket with polyethylene glycol 400 twice to obtain a lotion, and the suspension B includes lotion;

[0022] Stir solution A and suspension B slowly at 55°C for 25 minutes an...

Embodiment 2

[0024] A kind of mupirocin ointment, its raw material comprises by weight: 100 parts of mupirocin, 700 parts of polyethylene glycol 3350, 600 parts of polyethylene glycol 400, 2 parts of vitamin E, 58 parts of propylene glycol.

[0025] The preparation method of above-mentioned mupirocin ointment, comprises the steps:

[0026] Take the preparation tank and keep it dry at 85°C for 30 minutes, then add polyethylene glycol 400 to the preparation tank, raise the temperature to 75°C, add polyethylene glycol 3350 and propylene glycol and stir slowly to melt and clarify the polyethylene glycol 3350, and cool down to 60°C °C to obtain solution A;

[0027] Add polyethylene glycol 400 into a stainless steel bucket, then add mupirocin and vitamin E and mix to obtain a suspension B, wherein, rinse the stainless steel bucket with polyethylene glycol 400 twice to obtain a lotion, and the suspension B includes lotion;

[0028] Stir solution A and suspension B slowly at 65°C for 15 minutes ...

Embodiment 3

[0030] A kind of mupirocin ointment, its raw material comprises by weight: 50 parts of mupirocin, 500 parts of polyethylene glycol 3350, 400 parts of polyethylene glycol 400, 1 part of vitamin E, 49 parts of propylene glycol.

[0031] The preparation method of above-mentioned mupirocin ointment, comprises the steps:

[0032] Take the preparation tank and keep it dry at 85°C for 30 minutes, then add polyethylene glycol 400 to the preparation tank, raise the temperature to 72°C, add polyethylene glycol 3350 and propylene glycol and stir slowly to melt and clarify the polyethylene glycol 3350, and cool down to 63 °C to obtain solution A;

[0033] Add polyethylene glycol 400 into a stainless steel bucket, then add mupirocin and vitamin E and mix to obtain a suspension B, wherein, rinse the stainless steel bucket with polyethylene glycol 400 twice to obtain a lotion, and the suspension B includes lotion;

[0034] Stir solution A and suspension B slowly at 60°C for 20 minutes and ...

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Abstract

The invention discloses a mupirocin ointment. The ointment is prepared from the following raw materials in parts by weight: 20 to 100 parts of mupirocin, 500 to 700 parts of polyethylene glycol 3350,400 to 600 parts of polyethylene glycol 400, 1 to 2 parts of vitamin E and 39 to 58 parts of propylene glycol. The invention also discloses a preparation method of the mupirocin ointment. The method comprises the following steps: taking the polyethylene glycol 400, adding the polyethylene glycol 3350 and the propylene glycol, and performing uniform mixing to obtain a solution A; taking the polyethylene glycol 400, adding the mupirocin and the vitamin E, and performing uniform mixing to obtain a suspension B; and uniformly mixing the solution A and the suspension B at 55-65 DEG C, cooling obtained mixture to 35-45 DEG C, performing grinding, cooling ground material to room temperature, and performing canning to obtain the ointment. The ointment has uniformly-distributed active ingredients,has proper consistency, is easy to smear, and is convenient for patients to use.

Description

technical field [0001] The invention relates to the technical field of chemical preparations, in particular to a mupirocin ointment and a preparation method thereof. Background technique [0002] Mupirocin Ointment, trade name: It is a new type of topical antibiotic, which is a metabolite produced in the culture medium of Pseudomonas fluorescens, Pseudomonas A. This product was approved by FDA in 1987. The chemical structure and mechanism of action of mupirocin are different from those of other types of antibiotics, and the emergence of drug resistance can be avoided in the near future; it has high activity against common skin Gram-positive bacteria, especially under acidic conditions; it does not produce contact allergy Reaction, non-irritating and toxic, safe to use. It is clinically suitable for primary skin infections such as bacterial infection impetigo, furunculosis, folliculitis, and secondary infections such as eczema combined infection, ulcer combined infection,...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/351A61K47/10A61K47/22A61P31/04
CPCA61K9/0014A61K9/06A61K31/351A61K47/10A61K47/22A61P31/04
Inventor 戴小华程璐朱克旭吴剑张言君
Owner FRONT PHARM PLC
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