Preparation method of pectolinarin reference substance

A technology for crude fish leaf glycosides and fish leaf glycosides, which is applied in the field of modernization of traditional Chinese medicine, and can solve problems such as poor solubility of fish leaf glycosides, difficulty in separating monomers, and insufficient supply
CN110835362AActive Publication Date: 2020-02-25上海诗丹德标准技术服务有限公司 +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
上海诗丹德标准技术服务有限公司
Publication Date
2020-02-25

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Abstract

The invention discloses a preparation method of a pectolinarin reference substance. In particular, the method of the present invention comprises the steps of: (i) providing an alcohol extract of pectolinarin; (ii) dissolving the alcohol extract by using a NaOH aqueous solution, separating the alcohol extract by using a polyamide column through an eluent, and performing concentrating to obtain a semi-finished product of the pectolinarin; (iii) dissolving the semi-finished product of the pectolinarin, and separating the semi-finished product by utilizing a medium-pressure preparation column so as to obtain a crude product of the pectolinarin; (iv) carrying out alkali dissolution and acid precipitation on the crude product of the pectolinarin, filtering to obtain a solid, carrying out hot dissolution and cold precipitation on the solid by using methanol, and carrying out suction filtration to obtain a pure product of the pectolinarin; and (v) concentrating and freeze-drying the pure product to obtain the pectolinarin reference substance. The method is stable in process, convenient to operate, high in separation efficiency, low in cost, economical and environmentally friendly, and hashigh economic value and academic value.
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Description

technical field

[0001] The invention belongs to the technical field of modernization of traditional Chinese medicine, and relates to a preparation method of a chemical reference substance of traditional Chinese medicine. Specifically, the invention provides a preparation method of a reference substance of salicyloside leaf glycoside. Background technique

[0002] Large thistle is the dry aboveground part of Cirsium japonicum Fisch.ex DC., which is a plant in the Compositae family. The aboveground part is harvested when the flowers bloom in summer and autumn, removed from impurities, and dried in the sun. The chemical components of thistle mainly include triterpenes and steroids, volatile oils, flavonoids and flavonoid glycosides, long-chain enynols, organic acids and other compounds. Clinically, thistle is sweet in taste, slightly bitter, cool in nature, and has the functions of "eliminating congestion, generating new blood, stopping vomiting blood, stopping nosebleeds and e...

Claims

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