Large-scale preparation method and applications of high-purity scopoletin
A technology of scopolide and isocratic elution, applied in the directions of organic chemistry, organic chemistry, etc., can solve the problems such as complicated steps, failure to realize large-scale production, unrepeatable method and the like
Active Publication Date: 2020-02-28
CHONGQING UNIV +1
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[0006] In addition, it can also be synthesized by reacting 2,4-dihydroxyanisole with 3,3-diethoxy ethyl propionate and 6,7-dimethoxycoumarin as raw material through two-step reaction and p-benzoquinone as raw material, synthesized by microwave heating, but the above methods have not been able to achieve large-scale production and obtain high-purity scopoletin
[0007] In the early stage, we used tobacco leaves as raw materials to obtain scopoletin through extraction, macroporous resin, normal phase silica gel column chromatography, and thin layer chromatography to obtain scopoletin, but the steps are complicated and the method cannot be repeated.
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[0041] Hereinafter, the present invention will be further described in detail in conjunction with embodiments. It should be pointed out that the following specific descriptions are all illustrative and are intended to provide further description of the present invention. Unless otherwise specified, all scientific and technical terms used in the present invention have the same meanings as commonly understood by those skilled in the art to which the present invention belongs.
[0042] The present invention provides a method for extracting active components of tobacco sticks, please refer to figure 1 As shown in the flowchart, the extraction method may include the following steps:
[0043] 1. The extraction steps of scopoletin are as follows:
[0044] (1) Pretreatment.
[0045] Weigh 30Kg of raw tobacco sticks and place them in an oven for drying. The drying temperature is 60℃, the drying time is 4h, and the tobacco sticks are dried until the moisture content is less than 5%. Take out t...
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Abstract
The invention establishes a new method for obtaining high-purity natural scopoletin and a scopoletin crystal from waste tobacco branches on a large scale. According to the invention, scopoletin with apurity of 99.94% is obtained by using waste tobacco branches as a raw material through solvent extraction and industrial-grade high-performance liquid chromatography system separation and purification while a scopoletin crystal is obtained and the space structure of the scopoletin crystal is identified; and the extraction and separation method is stable and controllable, the large-scale production is achieved, and the method is widely applied to the fields of medicine, chemical engineering and the like.
Description
Technical field [0001] The invention relates to the technical field of tobacco stick product processing and extraction, in particular to an extraction and crystallization method of high-purity scopoletin and its application. Background technique [0002] Tobacco, also called fairy grass, is a traditional Chinese medicinal material. Its inorganic components include water and mineral elements; the organic components mainly include sugars, alkaloids, heterocyclics, pigments, phenols, terpenes, organic acids, and lipids. Quality, alcohols, aldehydes and ketones, etc. Among them, the organic components in tobacco have various functions such as antibacterial, antiviral, antitumor, antioxidant activity, and scavenging free radicals in the body. [0003] Scopolactone is also called scopolamine. Its molecular formula is C10H8O4. It is soluble in hot ethanol, slightly soluble in water or cold ethanol, and easily soluble in chloroform. It is a free coumarin compound. It is widely found in pl...
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IPC IPC(8): C07D311/16
CPCC07D311/16C07B2200/13
Inventor 陈玉皎王贵学钟莉曹军张时山刘政耿书莉
Owner CHONGQING UNIV