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Application of pyrroloquinoline quinone in preparation of medicine for preventing and treating acute altitude sickness and acute high altitude hypoxic injury

A technology of pyrroloquinoline quinone and altitude sickness, which is applied in the directions of drug combination, pharmaceutical formulation, organic active ingredients, etc., can solve problems such as gastrointestinal discomfort, confusion, and no pyrroloquinoline quinone, and achieves easy acceptance and toxicity. Low, improve the effect of high altitude body work ability

Inactive Publication Date: 2020-03-10
ZHE JIANG MEDICINE CO LTD XINCHANG PHARMA FAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, acetazolamide is likely to cause adverse reactions such as hyperchloremic metabolic acidosis, numbness of limbs, gastrointestinal discomfort, confusion, nausea, anorexia, drowsiness, polyuria and tinnitus; because 12 kinds of carbonic anhydrase have enzymatic activity isoenzymes, their tissue / organ distribution, subcellular localization, and physiological functions are quite different, and acetazolamide has a strong inhibitory effect on a variety of carbonic anhydrase isoenzymes
However, there is no research and application report on the use of pyrroloquinoline quinone in the prevention and treatment of acute plateau hypoxic injury

Method used

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  • Application of pyrroloquinoline quinone in preparation of medicine for preventing and treating acute altitude sickness and acute high altitude hypoxic injury
  • Application of pyrroloquinoline quinone in preparation of medicine for preventing and treating acute altitude sickness and acute high altitude hypoxic injury
  • Application of pyrroloquinoline quinone in preparation of medicine for preventing and treating acute altitude sickness and acute high altitude hypoxic injury

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Embodiment Construction

[0007] The present invention is further specifically described through the following examples, but not limited to the following examples and the range of process parameters in the examples.

[0008] 1. Materials

[0009] 1.1 Experimental animals

[0010] Kunming mice, clean grade, female / male, weighing 16-22 g, were provided by the Animal Center of the Academy of Military Medical Sciences.

[0011] Wistar rats, clean grade, male, weighing 160-220 g, were provided by the Animal Center of the Academy of Military Medical Sciences.

[0012] 1.2 Main reagents

[0013] PQQ (Xinchang Pharmaceutical, batch number: 150502)

[0014] Acetazolamide, content: 99.9%, (Chengdu Youlian Biotechnology Co., Ltd., batch number: 260905091)

[0015] NO kit, Coomassie Brilliant Blue kit (Beijing Puer Weiye Biotechnology Co., Ltd.)

[0016] ET-1 enzyme-linked immunoassay kit (Beijing Poole Weiye Biotechnology Co., Ltd.)

[0017] Oxidative Stress SOD, CO, MDA Detection Kit (Nanjing Jiancheng Tec...

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Abstract

The invention relates to an application of pyrroloquinoline quinone (PQQ) in preparation of a medicine for preventing and treating acute altitude sickness and acute high altitude hypoxic injury. The pyrroloquinoline quinine provided by the invention has the effect of preventing and treating the acute high altitude hypoxic injury, the efficacy is equivalent to that of acetazolamide, but the acetazolamide has large toxic and side effects, and the pyrroloquinoline quinone has the advantages of low toxicity and easy acceptance by patients as a coenzyme; and in addition, through exhaustive swimmingexperiments of mice under hypoxic exposure conditions, results show that the PQQ has the characteristics of improving the physical working ability at altitude, but the acetazamide is not found to have the effect.

Description

technical field [0001] The present invention relates to a new application of pyrroloquinoline quinone, in particular to the application of pyrroloquinoline quinone in the preparation of medicines for preventing and treating acute plateau hypoxic injury. Background technique [0002] Low pressure and hypoxia in plateau areas are the main environmental factors in plateau areas and the main pathogenic factors of altitude sickness. With the development of the west of the country and the opening of the Qinghai-Tibet Railway, the number of plateau practitioners and tourists is increasing day by day. The health maintenance of people entering the plateau area has also attracted more and more attention, and has become an important direction for the research of plateau medicine or health care products. [0003] At present, the treatment of high altitude polycythemia requires taking more than 250 mg of acetazolamide per day. However, acetazolamide is likely to cause adverse reactions ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4745A61P39/00
CPCA61K31/4745A61P39/00A61P43/00A61P3/00C07D471/06
Inventor 邵东孙新强劳学军刘卫张维才
Owner ZHE JIANG MEDICINE CO LTD XINCHANG PHARMA FAB
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