Skin topical composition with efficacy of promoting wound healing and/or scar repair

A composition for external use and wound healing technology, which is applied in the direction of medical preparations containing active ingredients, drug combinations, skin diseases, etc., and can solve problems such as difficult to cure, long cycle, large toxic and side effects, etc.

Active Publication Date: 2020-03-13
NATURAL MEDICINE INST OF ZHEJIANG YANGSHENGTANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are shortcomings such as slow effect, long cycle, difficult to cure, and large toxic and side effects.

Method used

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  • Skin topical composition with efficacy of promoting wound healing and/or scar repair
  • Skin topical composition with efficacy of promoting wound healing and/or scar repair
  • Skin topical composition with efficacy of promoting wound healing and/or scar repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Cell Viability Assay

[0040] The cells used in this test are human-derived fibroblasts, obtained by Guangdong Boxi Biotechnology Co., Ltd. through primary and subculture.

[0041] 1.1 Reagents

[0042] Cell culture medium (Gibco), newborn bovine serum (Sijiqing), PBS (Boster), MTT (Sigma), DMSO (Sigma).

[0043] 1.2 Main equipment

[0044] CO 2 Incubator (Thermo), ultra-clean bench (Sujing Antai), inverted microscope (Olympus), micro shaker (Qilin Bell), microplate reader (BioTek), incubator (Test).

[0045] 1.3 Test samples

[0046] The fresh white birch sap stock solution purchased from Daxinganling Chaoyue Wild Berry Development Co., Ltd. was input into a low-temperature drying equipment, cooled to -65°C, vacuumed to 0.1Pa, and concentrated to 1.2 times, 2 times, 3 times, and 5 times respectively.

[0047] 1.4 Cell Viability Detection

[0048] (1) Cell inoculation: Inoculate cells into 96-well plates at a seeding density of 1E4 per well, incubator (...

Embodiment 2

[0056] Example 2: Cell Migration Experiment

[0057] 2.1 Source of cells

[0058] The cells used in this test are human-derived fibroblasts, obtained by Guangdong Boxi Biotechnology Co., Ltd. through primary and subculture.

[0059] 2.2 Reagents

[0060] Cell culture medium (Gibco), newborn bovine serum (Sijiqing), PBS (Boster), 60mm culture dish (Coring), fibronectin (Sigma).

[0061] 2.3 Main equipment

[0062] Phase contrast microscope (Olympus)

[0063] 2.4 Experimental samples

[0064] The fresh white birch sap stock solution purchased from Daxinganling Chaoyue Wild Berry Development Co., Ltd. was input into a low-temperature drying equipment, cooled to -65°C, vacuumed to 0.1Pa, and concentrated to 3 times.

[0065] When adding a sample, the sample amount of a single raw material is a whole raw material; the compound raw material is half a birch sap raw material plus half a 0.1% other active raw material. The samples tested included: 3x Concentrated Birch Juice, Bur...

Embodiment 3

[0073] Example 3: Rat full-thickness skin defect wound model

[0074] 3.1 Experimental animals

[0075] Purchase 6-7-week-old male SD rats, half male and half male, and feed them continuously for 1 week until the rats adapt to the experimental environment.

[0076] 3.2 Experimental samples

[0077] The fresh white birch sap stock solution purchased from Daxinganling Chaoyue Wild Berry Development Co., Ltd. was input into a low-temperature drying equipment, cooled to -65°C, vacuumed to 0.1Pa, and concentrated to 1.5 times.

[0078] When adding a sample, the sample amount of a single raw material is a whole raw material; the compound raw material is half a birch sap raw material plus half a 0.1% other active raw material. The samples tested included: 1.5 times concentrated birch juice, comfrey extract, allantoin, 1.5 times concentrated birch juice + comfrey root extract, and 1.5 times concentrated birch juice + allantoin.

[0079] 3.3 Modeling method

[0080] (1) SD rats wer...

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PUM

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Abstract

The invention relates to a skin topical composition with the efficacy of promoting wound healing and/or scar repair. The skin topical composition includes (A) concentrated birch sap, and (B) one or more of Sanguisorba root extract, Coptis root extract, Arnebia extract, allantoin, Salvia miltiorrhiza extract, astragalus extract, pearl powder and asiaticoside, wherein the concentrated birch sap hasa concentration multiple of about 1.2-6 times, preferably about 1.5-5 times, more preferably about 1.5-3 times.

Description

technical field [0001] The present invention relates to a composition for external use on the skin with the effect of promoting wound healing and / or scar repair, which comprises (A) concentrated birch sap, and (B) Burnet elm root extract, Coptis chinensis root extract, comfrey extract extract, allantoin, salvia miltiorrhiza extract, astragalus extract, pearl powder and asiaticoside, wherein the concentration ratio of the concentrated birch juice is about 1.2-6 times, preferably about 1.5 times -5 times, more preferably about 1.5-3 times. Background technique [0002] The damage caused by skin burning, scalding, trauma, etc. is one of the common skin diseases that endanger human health and life safety. The resulting skin wound results in a breakdown of the integrity of the skin epithelium and may be accompanied by disruption of the structure and function of the underlying normal tissue. During the wound healing process, there are often situations such as pain in the affecte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K36/30A61K36/481A61K36/537A61K36/718A61K36/739A61P17/02A61K8/98A61K8/9789A61K8/60A61K8/49A61Q19/00A61K31/4166A61K31/7024A61K35/618
CPCA61K36/185A61K36/739A61K36/718A61K36/30A61K31/4166A61K36/537A61K36/481A61K35/618A61K31/7024A61P17/02A61K8/987A61K8/9789A61K8/602A61K8/4946A61Q19/00A61K2300/00A61K31/704A61K9/0014A61K2800/591
Inventor 赵瑞丽
Owner NATURAL MEDICINE INST OF ZHEJIANG YANGSHENGTANG
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