Novel method for synthesizing 2-amino-3, 5-dibromopyrazine, product and application

A technology of dibromopyrazine and aminopyrazine, applied in the direction of organic chemistry, can solve the problems of large environmental pollution, unsuitable for industrial production, and low product purity
CN110878056AInactive Publication Date: 2020-03-13上海鑫响实业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
上海鑫响实业有限公司
Publication Date
2020-03-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a new method for synthesizing 2-amino-3, 5-dibromopyrazine, a product and an application. The method comprises the following steps: step 1, taking 2-cyanopyrazine and sodium hypochlorite as raw materials, carrying out reaction under inorganic alkali aqueous solution conditions, and then carrying out reduced pressure distillation to obtain 2-aminopyrazine; step 2, taking N,N-dimethylacetamide as a solvent, adding 1, 3-dibromo-5, 5-dimethylhydantoin, dropwise adding an N, N-dimethylacetamide solution of 2-aminopyrazine, and carrying out reaction for 15 to 20 h so as to obtain a 2-amino-3, 5-dibromopyrazine crude product; carrying out subsequent treatment on the 2-amino-3, 5-dibromopyrazine crude product with heptane and ethanol to obtain the 2-amino-3, 5-dibromopyrazine disclosed by the invention. The invention provides the new method for synthesizing 2-amino-3, 5-dibromopyrazine, the yield of the product is improved, the purification problem of the product is solved, and meanwhile, the synthesis cost of the product is reduced.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and specifically relates to a new method, product and application for synthesizing 2-amino-3,5-dibromopyrazine. Background technique

[0002] At present, the synthetic report of 2-amino-3,5-dibromopyrazine is less, and there are some shortcomings, disclose a kind of preparation method of 2-aminopyrazine derivative as patent CN108570011A, comprise the following steps: C1: to Add sodium hypochlorite solution and alkali in sequence to 2-cyanopyrazine, and then stir to obtain 2-aminopyrazine; C2: add the 2-aminopyrazine obtained in step C1 to a brominating agent for bromination reaction to obtain 2-aminopyrazine -3,5-Dibromopyrazine. The disadvantages of this patent are: the prepared product has low purity, low yield, high cost, difficult treatment of waste water, and great environmental pollution.

[0003] Therefore, it is necessary to provide an improved technical solution to overcome t...

Claims

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